CAS No. 1383816-29-2

Batch: Purity:99.32
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Tropifexor (LJN452) Chemical Structure
Chemical Structure
Check the Tropifexor (LJN452) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(1R,5S)-3-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid
CAS Number 1383816-29-2
Molecular Formula

C29H25F4N3O5S
Molecular Weight (MW) 603.58
SMILES C1CC1C2=C(C(=NO2)C3=CC=CC=C3OC(F)(F)F)COC4CC5CCC(C4)N5C6=NC7=C(C=C(C=C7S6)C(=O)O)F
InChIKey VYLOOGHLKSNNEK-JWTNVVGKSA-N

Ordering Information

Biological Activity

Tropifexor (LJN452) is a highly potent agonist of farnesoid X receptor (FXR) with an EC50 ofin an HTRF assay, exhibiting over 10,000-fold selectivity for FXR over other receptors. Activation of FXR modulates bile acid, lipid, and glucose homeostasis pathways, leading to suppressed hepatic lipogenesis, reduced inflammation, and attenuated liver fibrosis in preclinical models of nonalcoholic steatohepatitis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (165.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.