CAS No. 77-86-1
Batch:
Purity:100.0
Chemical Structure
Check the
Trometamol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-amino-2-(hydroxymethyl)propane-1,3-diol | |
|---|---|---|
| CAS Number | 77-86-1 | |
| Molecular Formula |
C4H11NO3 |
|
| Molecular Weight (MW) | 121.14 | |
| SMILES | C(C(CO)(CO)N)O | |
| InChIKey | LENZDBCJOHFCAS-UHFFFAOYSA-N |
Biological Activity
Trometamol (tromethamine) is an organic amine buffer and proton acceptor that directly neutralizes excess hydrogen ions. By sequestering extracellular and intracellular protons, trometamol raises pH and restores acid-base equilibrium, preventing acidemia-induced physiological dysfunction. Consequently, this buffering activity stabilizes cellular metabolic processes, preserves enzymatic function, and protects cells from proton-mediated injury caused by severe acidic stress. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 24 mg/mL |
| DMSO |
2 mg/mL
(16.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.