CAS No. 738-70-5
| IUPAC Name | 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine | |
|---|---|---|
| CAS Number | 738-70-5 | |
| Molecular Formula |
C14H18N4O3 |
|
| Molecular Weight (MW) | 290.32 | |
| SMILES | COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N | |
| InChIKey | IEDVJHCEMCRBQM-UHFFFAOYSA-N |
Trimethoprim is a synthetic bacteriostatic antibiotic and potent inhibitor of bacterial dihydrofolate reductase (DHFR). By selectively binding to bacterial DHFR, it halts the reduction of dihydrofolic acid to tetrahydrofolic acid, thereby depleting necessary precursors for bacterial thymidine, purine, and DNA synthesis. This disruption of the folate biosynthesis pathway leads to the inhibition of bacterial cell growth and division across various Gram-positive and Gram-negative pathogens. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
58 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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