CAS No. 13171-25-0
| CAS Number | 13171-25-0 | |
|---|---|---|
| Molecular Formula |
C14H22N2O3.2HCl |
|
| Molecular Weight (MW) | 339.26 | |
| SMILES | COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC.Cl.Cl |
Trimetazidine dihydrochloride is a fatty acid oxidation inhibitor that selectively targets mitochondrial long-chain 3-ketoacyl-coenzyme A thiolase. By inhibiting fatty acid metabolism, it shifts cellular energy production toward myocardial glucose utilization and oxidation. This metabolic shift helps preserve cellular adenosine triphosphate levels, limits intracellular acidosis, maintains ion homeostasis, and protects cultured cardiomyocytes against hypoxia-induced injury. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(200.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 68 mg/mL |
| Ethanol | 5 mg/mL |
| DMSO |
67 mg/mL
(197.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 67 mg/mL |
| Ethanol | 1 mg/mL |
| DMSO |
67 mg/mL
(197.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 67 mg/mL |
| Ethanol | 67 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- Trimetazidine dihydrochloride SDS｜MSDS