CAS No. 13171-25-0
Batch:
Purity:99.97
Chemical Structure
Check the
Trimetazidine dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 13171-25-0 | |
|---|---|---|
| Molecular Formula |
C14H22N2O3.2HCl |
|
| Molecular Weight (MW) | 339.26 | |
| SMILES | COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC.Cl.Cl |
Biological Activity
Trimetazidine dihydrochloride is a fatty acid oxidation inhibitor that selectively targets mitochondrial long-chain 3-ketoacyl-coenzyme A thiolase. By inhibiting fatty acid metabolism, it shifts cellular energy production toward myocardial glucose utilization and oxidation. This metabolic shift helps preserve cellular adenosine triphosphate levels, limits intracellular acidosis, maintains ion homeostasis, and protects cultured cardiomyocytes against hypoxia-induced injury. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(200.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 68 mg/mL |
| Ethanol | 5 mg/mL |
| DMSO |
67 mg/mL
(197.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 67 mg/mL |
| Ethanol | 1 mg/mL |
| DMSO |
67 mg/mL
(197.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 67 mg/mL |
| Ethanol | 67 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Trimetazidine dihydrochloride Clinical Trials
- Trimetazidine dihydrochloride Solubility in DMSO
- Trimetazidine dihydrochloride Stock Solution
- Trimetazidine dihydrochloride Storage
- Trimetazidine dihydrochloride Stability
- Trimetazidine dihydrochloride Molecular Weight
- Trimetazidine dihydrochloride SMILES
- Trimetazidine dihydrochloride Chemical Structure (2D and 3D)
- Trimetazidine dihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.