CAS No. 52-49-3

Batch: Purity:99.96
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Trihexyphenidyl hydrochloride Chemical Structure
Chemical Structure
Check the Trihexyphenidyl hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride
CAS Number 52-49-3
Molecular Formula

C20H31NO.HCl
Molecular Weight (MW) 337.93
SMILES C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O.Cl
InChIKey QDWJJTJNXAKQKD-UHFFFAOYSA-N

Ordering Information

Biological Activity

Trihexyphenidyl hydrochloride is a synthetic antimuscarinic agent that acts as a selective antagonist of muscarinic acetylcholine receptors, with higher affinity for the M1 receptor subtype. By blocking muscarinic acetylcholine receptor activation, it suppresses cholinergic neurotransmission and downstream intracellular signaling cascades. This antagonism leads to reduced cholinergic signaling and modulation of neuronal excitability in central and peripheral nervous system pathways. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 20 mg/mL (59.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 20 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.