CAS No. 289480-64-4
Batch:
Purity:99.52
Chemical Structure
Check the
Treprostinil sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 289480-64-4 | |
|---|---|---|
| Molecular Formula |
C23H33NaO5 |
|
| Molecular Weight (MW) | 412.49 | |
| SMILES | CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)[O-])O)O.[Na+] | |
| InChIKey | RCKWZOAISRYANP-ZSESPEEFSA-N |
Treprostinil sodium is a synthetic prostacyclin analog that functions as a potent agonist of DP1 (Ki 4.4 nM), EP2 (Ki 3.6 nM), and IP (Ki 32 nM) receptors. Receptor engagement stimulates adenylate cyclase activity, elevating intracellular cAMP levels. This downstream signaling cascade promotes vasodilation of pulmonary arterial vascular beds while suppressing vascular smooth muscle cell proliferation and platelet aggregation.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(198.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 82 mg/mL |
| Ethanol | 82 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Treprostinil sodium Clinical Trials
- Treprostinil sodium Solubility in DMSO
- Treprostinil sodium Stock Solution
- Treprostinil sodium Storage
- Treprostinil sodium Stability
- Treprostinil sodium Molecular Weight
- Treprostinil sodium SMILES
- Treprostinil sodium Chemical Structure (2D and 3D)
- Treprostinil sodium SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.