Tranexamic Acid Clinical Trials

Size	Price	Qty
50mg	USD 147
1g	USD 670

Clinical Trials

Numerous clinical trials evaluate the therapeutic efficacy of tranexamic acid across surgical and traumatic hemorrhagic conditions, including postpartum hemorrhage, perioperative blood loss, traumatic brain injury, pediatric trauma, and endobronchial bleeding. Spanning early-phase through late-phase interventions, these studies encompass diverse recruitment statuses—including completed, actively recruiting, and not yet recruiting—and are sponsored by major academic institutions and university medical centers. Ultimately, this research underscores the broad critical care and surgical applications of tranexamic acid.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04387305	NOT_YET_RECRUITING	Brain Injuries, Traumatic; Wounds and Injury; Hemorrhage; Trauma Injury	Daniel Nishijima, MD, MAS	2026-10-01	PHASE3
NCT06718751	NOT_YET_RECRUITING	Chronic Subdural Hematoma	Baylor College of Medicine	2025-10	PHASE2
NCT07116395	NOT_YET_RECRUITING	Patients Undergoing Operative Fixation of Long Bone Fractures Within the Community Medical Centers System	Arbi Nazarian, MD	2027-01-01	PHASE4
NCT07494032	NOT_YET_RECRUITING	Knee Arthropathy	NYU Langone Health	2026-05-01
NCT03582293	RECRUITING	Hematoma, Subdural, Chronic	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2018-06-19	PHASE3
NCT06270407	RECRUITING	Surgical Complication	St. Olavs Hospital	2024-09-18	PHASE4
NCT07362992	RECRUITING	Cesarean Delivery; Postpartum Hemorrhage (PPH); Intraoperative Blood Loss; Hemostasis	Wolfson Medical Center	2026-07-01	EARLY_PHASE1
NCT07245264	RECRUITING	Chronic Subdural Hematoma	St. Olavs Hospital	2025-12-10	PHASE2; PHASE3
NCT07644923	NOT_YET_RECRUITING	Postoperative Pain	NYU Langone Health	2026-08-01	PHASE4
NCT07672158	NOT_YET_RECRUITING	Cerebral Palsy; Hip Surgery Corrective; Tranexamic Acid Use; Blood Loss, Surgical; Paediatrics; Orthopedics	Murdoch Childrens Research Institute	2026-07	PHASE3
NCT06519422	RECRUITING	Anaemia	London School of Hygiene and Tropical Medicine	2026-08-10	PHASE3
NCT06902714	RECRUITING	Shoulder Arthroplasty	University of Alabama at Birmingham	2026-04-20	PHASE3
NCT07734740	NOT_YET_RECRUITING	Dermatochalasis of Upper Eyelid; Blepharoplasty	Prince of Wales Hospital, Shatin, Hong Kong	2026-08	PHASE3
NCT06070350	RECRUITING	Hemorrhagic Shock; Trauma Injury	Philip Spinella	2024-11-01	PHASE3
NCT07685743	NOT_YET_RECRUITING	Osteoarthritis (OA) of the Hip; Osteoarthritis (OA) of the Knee	Oregon Health and Science University	2026-09-01	PHASE4
NCT07679139	NOT_YET_RECRUITING	Bleeding After GI Endoscopy	National Cheng-Kung University Hospital	2026-07-01
NCT07501884	NOT_YET_RECRUITING	Urethral Stricture; Urethral Diseases	Amjad Alwaal, MD, MSc, FRCSC, FACS	2026-09-01	PHASE4
NCT07540026	RECRUITING	Bleeding After GI Endoscopy	National Cheng-Kung University Hospital	2026-05-01
NCT07474077	NOT_YET_RECRUITING	Post Partum Haemorrhage	Sultan Qaboos University	2026-05-01	PHASE3
NCT07164300	RECRUITING	Blood Coagulation Disorder; Postoperative Blood Loss; Adverse Drug Event; Fibrinolysis; Hemorrhage; Tranexamic Acid Adverse Reaction	University of Ioannina	2024-05-14
NCT06379724	RECRUITING	Burns; Skin Graft Complications	University of Kansas Medical Center	2024-07-11	PHASE4
NCT06736860	RECRUITING	Trauma Coagulopathy	Nanfang Hospital, Southern Medical University	2024-08-01	PHASE4
NCT06657924	RECRUITING	Bleeding; Colorectal Disorders; Thromboembolism; Tranexamic Acid	Kristen Ban	2025-02-11	PHASE2
NCT06618820	ENROLLING_BY_INVITATION	Osteo Arthritis Knee; Pain, Postoperative	Campbell Clinic	2024-09-17	PHASE3
NCT05053867	RECRUITING	Pulmonary Hemorrhage; Cancer	M.D. Anderson Cancer Center	2022-10-14	PHASE3
NCT06356948	RECRUITING	Healthy Participants	University of British Columbia	2024-03-30	PHASE4
NCT03063892	ACTIVE_NOT_RECRUITING	Hip Fractures	Gregory M Georgiadis MD	2017-08-30	PHASE4
NCT07641946	NOT_YET_RECRUITING	Hemoptysis; Pulmonary Hemorrhage	Assiut University	2026-07	PHASE3
NCT07365150	RECRUITING	Intracerebral Hemorrhage	The University of Hong Kong	2026-01-01
NCT04304625	RECRUITING	Postpartum Hemorrhage	University Hospital, Bordeaux	2020-08-07	PHASE3
NCT07581457	RECRUITING	Scoliosis Idiopathic; Scoliosis; Adolescence	Poznan University of Medical Sciences	2026-06-01
NCT07432737	RECRUITING	Hip Fractures	University Hospital for Surgical Diseases St. Naum Ohridsk i- Skopje	2026-02-17
NCT06820177	RECRUITING	Abortion; Dilation and Evacuation; Hemorrhage; Prophylactic Tranexamic Acid Use; Blood Loss	University of California, San Diego	2025-04-22	PHASE4
NCT06208267	RECRUITING	Postoperative Bleeding	St. Mary's Research Center, Canada	2025-08-20
NCT07131592	RECRUITING	Drain Output After Breast Reduction Surgery; Breast Reductions	Massachusetts General Hospital	2025-11-18	PHASE4
NCT03553186	RECRUITING	Spinal Deformity; Degenerative Lumbar Spinal Stenosis; Blood Loss, Surgical	Hospital for Special Surgery, New York	2018-07-11	PHASE3
NCT06337838	RECRUITING	Chronic Kidney Diseases; Acute Kidney Injury; Bleeding; Surgery	Hamilton Health Sciences Corporation	2025-06-09	PHASE3
NCT06754371	RECRUITING	Postpartum Hemorrhage; Systemic Autoimmune Diseases	RenJi Hospital	2025-01-06	PHASE4
NCT06450392	RECRUITING	Orbital Edema; Orbital Ecchymosis	Montefiore Medical Center	2024-10-07	PHASE4
NCT07127042	RECRUITING	Total Knee Arthroplasty	ScinnoHub Pharmaceutical Co., Ltd.	2025-08-27	PHASE2
NCT06109155	RECRUITING	Surgery, Cardiac; Tranxemic Acid; Activated Clotting Time; Heparin; Cardiopulmonary Bypass	Taichung Veterans General Hospital	2024-02-08	PHASE4
NCT04521881	RECRUITING	Traumatic Brain Injury	London School of Hygiene and Tropical Medicine	2021-04-18	PHASE3
NCT06894719	NOT_YET_RECRUITING	Total Knee Arthroplasty	Rush University Medical Center	2026-09-01	PHASE4
NCT03849443	RECRUITING	Open Posterior Thoracolumbar Spinal Fusion Procedure	Rush University Medical Center	2019-08-26	EARLY_PHASE1
NCT06427850	NOT_YET_RECRUITING	Degenerative Spine Diseases; Surgical Wound	Thanawan Longsuwan	2024-07-01
NCT07495748	NOT_YET_RECRUITING	Melasma	Foundation University Islamabad	2026-07-01
NCT06384456	RECRUITING	Distal Radius Fractures	University Health Network, Toronto	2025-08-13	PHASE4
NCT06414031	RECRUITING	Surgical Blood Loss; Transfusion-dependent Anemia; Abdomen Disease	Ulrich Ronellenfitsch, MD	2024-06-17	PHASE3
NCT07522788	NOT_YET_RECRUITING	Melasma	Hayatabad Medical Complex	2026-06-01	PHASE4
NCT07714473	NOT_YET_RECRUITING	Rotator Cuff Tear Repair	Hua Luo	2026-08-01
NCT05370820	RECRUITING	Post Partum Hemorrhage	Inova Health Care Services	2022-12-28	PHASE2
NCT05836831	RECRUITING	Intracerebral Hemorrhagic Stroke	Christian Medical College and Hospital, Ludhiana, India	2022-08-30	PHASE4
NCT05345613	RECRUITING	Colon Neoplasm	Assaf-Harofeh Medical Center	2022-05-01	PHASE4
NCT04803591	WITHDRAWN	Femoral Shaft Fracture	Christian Candrian	2021-08-01	PHASE4
NCT05899465	RECRUITING	Melanoma	University of Aarhus	2023-08-25	PHASE3
NCT07423156	NOT_YET_RECRUITING	Placenta Previa	Allama Iqbal Medical College	2026-03-01	PHASE3
NCT05470816	ACTIVE_NOT_RECRUITING	Surgical Site Infection; Dementia; Cognition	Bayside Health	2022-11-01	PHASE3
NCT07078942	NOT_YET_RECRUITING	Pregnant Women Undergoing Cesarean Delivery	Chulalongkorn University	2025-07-20	PHASE4
NCT07727954	COMPLETED	Melasma	University of Guadalajara	2026-06-12
NCT06345833	WITHDRAWN	Hemophilia; Hemorrhage; Facelift Surgery	University of Minnesota	2024-07-01	EARLY_PHASE1
NCT07401394	ACTIVE_NOT_RECRUITING	Bariatric Surgery; Bariatric Patients; Bariatric Surgery Complications; Bleeding; Tranexamic Acid	Santa Maria Hospital - GVM Care & Research	2025-12-01
NCT07460518	NOT_YET_RECRUITING	Benign Prostatic Hyperplasia; Transurethral Resection of the Prostate; Perioperative Bleeding; Anemia, Postoperative	Hamza Najout	2026-03-15	PHASE4
NCT06983886	NOT_YET_RECRUITING	Postoperative Blood Loss in Patient Undergoing Orthognathic Surgery	Ramathibodi Hospital	2025-05-12	PHASE1; PHASE2
NCT04905901	COMPLETED	Bleeding Nose	Assiut University	2021-05-06	PHASE3
NCT07614087	NOT_YET_RECRUITING	Osteoarthritis	Hua Luo	2026-05-27	PHASE4
NCT07332910	NOT_YET_RECRUITING	ACL Reconstruction; Hemarthrosis	Chirec	2026-01-20	PHASE4
NCT05672407	WITHDRAWN	Eyelid Diseases; Periorbital Disorder; Hemorrhage; Surgical Blood Loss	University of Miami	2023-09-01	PHASE4
NCT06057675	RECRUITING	Postoperative Bleeding; Skin Cancer Face	Vanderbilt University Medical Center	2024-03-19	PHASE2
NCT03128866	ACTIVE_NOT_RECRUITING	Pelvic Mass	M.D. Anderson Cancer Center	2017-05-19	EARLY_PHASE1
NCT07582341	COMPLETED	Kidney Stones; Surgical Blood Loss; Percutaneous Nephrolithotomy	Benha University	2025-05-30	PHASE4
NCT06452342	UNKNOWN	Venous Thromboembolism; Venous Thromboses; Heavy Menstrual Bleeding; Anticoagulants and Bleeding Disorders	University Health Network, Toronto	2024-06	PHASE4
NCT07192640	NOT_YET_RECRUITING	Obese Patients; Obese Patients With Bariatric Surgery; Bleeding	Ain Shams University	2025-10-15
NCT07202156	RECRUITING	Melasma (Facial Melasma)	The First Affiliated Hospital with Nanjing Medical University	2024-10-20
NCT06023212	RECRUITING	Metastasis Spinal Tumor	Second Affiliated Hospital, Zhejiang University, School of Medicine	2023-12-01	PHASE1; PHASE2
NCT06622564	NOT_YET_RECRUITING	Bleeding; Surgical Blood Loss; Seizures	Hamilton Health Sciences Corporation	2025-01-01	PHASE3
NCT04811313	RECRUITING	Intraoperative Blood Loss; Pediatric; Orthopedic Disorder	Assiut University	2025-04-03
NCT07169383	ENROLLING_BY_INVITATION	Melasma (Facial Melasma)	Hina Malik	2025-06-28	PHASE2
NCT07263841	ACTIVE_NOT_RECRUITING	Post Burn Facial Hyperpigmentation	King Edward Medical University	2025-06-01	PHASE2
NCT06010368	NOT_YET_RECRUITING	Cesarean Section Complications; Tranexamic Acid; Oxytocin; Post Partum Hemorrhage	Cairo University	2024-10-01	PHASE3
NCT06025916	RECRUITING	PPH	Karolinska Institutet	2023-09-27	PHASE4
NCT06997796	RECRUITING	Epistaxis Nosebleed	Dr. Anne Conlin	2025-05	PHASE1; PHASE2
NCT05474027	COMPLETED	Hypotension During Surgery; Blood Loss, Surgical	University of Alabama at Birmingham	2022-11-11	PHASE4
NCT07034560	ACTIVE_NOT_RECRUITING	Melasma; Treatment Outcome; Recurrence	Thammasat University	2024-11-12	PHASE4
NCT06781021	ENROLLING_BY_INVITATION	ACL Tears	The University of The West Indies	2024-11-01
NCT07212452	COMPLETED	Hemoptysis; NEBULIZATION; Tranexamic Acid	University of Health Sciences Lahore	2025-08-01	PHASE2; PHASE3
NCT06490653	UNKNOWN	Epistaxis Nosebleed	Ankara Ataturk Sanatorium Training and Research Hospital	2024-10	PHASE4
NCT04192435	COMPLETED	Infection Wound; Gastrointestinal Complication; Anesthesia; Bleeding; Healthcare Associated Infection	Bayside Health	2022-05-18	PHASE4
NCT06091891	UNKNOWN	Scoliosis	Seoul National University Hospital	2023-10-16
NCT07610863	COMPLETED	Total Hip Arthroplasty; Tranexamic Acid Administration; Perioperative Blood Loss; Coagulation Monitoring Using ROTEM	St. Anne's University Hospital Brno, Czech Republic	2024-06-01
NCT06653699	COMPLETED	Hip Replacement; Knee Replacement	Indus Hospital and Health Network	2024-07-11
NCT04760301	RECRUITING	Blood Loss	Meir Medical Center	2021-02-16
NCT07392034	COMPLETED	Hemoglobin Level Measurement; Blood Loss During Surgery; Duration of Surgery	Nishtar Medical University	2025-01-01	PHASE2
NCT06777966	RECRUITING	Nebulization; Intravenous; Surgical Field; Endoscopic Sinus Surgeries	Cairo University	2025-01-18	PHASE4
NCT06522984	UNKNOWN	Refractory Melasma	Egymedicalpedia	2024-06-01
NCT07280234	COMPLETED	Melasma	Hayat Abad Medical Complex, Peshawar	2024-11-14	EARLY_PHASE1
NCT06428682	UNKNOWN	Breast Cancer; Blood Loss, Surgical	University of Virginia	2024-05-13	PHASE4
NCT04785651	TERMINATED	Monocompartimental Tibiofemoral Osteoarthritis; Osteoarthritis	Istituto Ortopedico Rizzoli	2021-02-22
NCT06434636	COMPLETED	Middle Ear Disease	TC Erciyes University	2024-12-01
NCT05806346	RECRUITING	Heart Diseases; Vascular Diseases; Transfusion Related Complication; Coagulation Disorder, Blood; Fibrinolysis; Hemorrhage	Konkuk University Medical Center	2023-08-01
NCT03822793	COMPLETED	Arthropathy of Hip	Centre Hospitalier Universitaire de Saint Etienne	2023-12-07	PHASE2
NCT07174895	COMPLETED	Osteoarthritis, Knee	Idlib University	2021-08-06
NCT06604325	RECRUITING	Post Partum Hemorrhage	Aligarh Muslim University	2024-10-01
NCT06516419	UNKNOWN	Melasma	Dr.dr.Irma Bernadette, SpKK (K)	2024-02-13
NCT06145191	COMPLETED	Bleeding; Hemoptysis	Clinical Hospital Centre Zagreb	2023-12-18
NCT06330935	UNKNOWN	Traumatic Brain Injury	Mansoura University	2024-03-25	PHASE1; PHASE2
NCT06479161	RECRUITING	Postoperative Pain	Matthew Grosso, MD	2024-06-10	PHASE2
NCT05811676	COMPLETED	Hemorrhage, Postpartum; Placenta Previa	Guangzhou Medical University	2023-07-12	PHASE3
NCT06491771	UNKNOWN	Cryotherapy Effect	Mahidol University	2024-07-01
NCT05688020	UNKNOWN	Gastric Polyp; Gastric Neoplasm; Duodenal Neoplasms; Esophageal Neoplasms	Assaf-Harofeh Medical Center	2023-02-01	PHASE4
NCT06419075	WITHDRAWN	Pelvic Organ Prolapse	The University of Texas Medical Branch, Galveston	2024-07-01	PHASE4
NCT05507983	UNKNOWN	Burns; Blood Loss, Surgical; Blood Loss; Tranexamic Acid; Burn Excisional Surgery	Maasstad Hospital	2021-12-01	PHASE3
NCT06515535	UNKNOWN	Placenta Previa	Cairo University	2024-07-24
NCT05639686	UNKNOWN	Rhinosinusitis Chronic; Sinus Cancer; Sinus Polyp; Encephalocele	Our Lady of the Lake Hospital	2023-01-01
NCT06149091	UNKNOWN	Iatrogenic Endobronchial Bleeding	China-Japan Friendship Hospital	2023-12-01	EARLY_PHASE1
NCT07625709	COMPLETED	Blood Loss, Postoperative; Blood Loss, Surgical; Femoral Fracture; Tibial Fracture	Kathmandu University School of Medical Sciences	2023-01-01
NCT05230381	UNKNOWN	Tranexamic Acid; Intraoperative Blood Loss; Meningioma	Beijing Tiantan Hospital	2022-06-15
NCT05957822	UNKNOWN	Arthritis Knee; Spine Fusion; Prostate Cancer; Arthritis of Hip; Hepatic Cancer	Konkuk University Medical Center	2024-02-10	PHASE4
NCT02568124	UNKNOWN	Chronic Subdural Hematoma	Centre de recherche du Centre hospitalier universitaire de Sherbrooke	2015-11	PHASE2; PHASE3
NCT05807074	TERMINATED	Breast Cancer	University of California, San Francisco	2023-04-20	PHASE4
NCT07753161	COMPLETED	Ligamentoplasty; Hemoglobin	GCS Ramsay Santé pour l'Enseignement et la Recherche	2022-02-03
NCT05441592	COMPLETED	Hematoma Postoperative	University of Michigan	2022-08-15	PHASE4
NCT06290596	UNKNOWN	Uterine Surgery	Al-Azhar University	2024-04-01	PHASE4
NCT06920264	COMPLETED	This Study Will Evaluate Whether TXA Reduces Pain	St. Louis Joint Replacement Institute	2021-07-01	PHASE1
NCT06369012	COMPLETED	Abnormal Uterine Bleeding	Egymedicalpedia	2024-03-01
NCT05464394	UNKNOWN	Hemorrhage; Bleeding	Franciscus Gasthuis	2022-09-01	PHASE3
NCT07125508	COMPLETED	Anemia; Small Bowel Bleeding; Angioectasias	Louisiana State University Health Sciences Center in New Orleans	2023-08-01	PHASE2; PHASE3
NCT04344860	COMPLETED	Von Willebrand Diseases; Postpartum Hemorrhage	Nicoletta C Machin	2021-06-04	PHASE3
NCT04797156	COMPLETED	Spine Surgery; Back Pain	Icahn School of Medicine at Mount Sinai	2021-03-03	EARLY_PHASE1
NCT04918589	UNKNOWN	Hematoma Postoperative; Breast Cancer; Tranexamic Acid	McMaster University	2022-08	PHASE3
NCT04918576	UNKNOWN	Hematoma Postoperative; Tranexamic Acid	McMaster University	2022-08	PHASE3
NCT04311073	UNKNOWN	Fibroid Uterus; Abnormal Uterine Bleeding; Myoma;Uterus	Eastern Virginia Medical School	2020-06-20	PHASE3
NCT03469947	COMPLETED	Hemorrhagic Shock; Trauma Injury	Arrowhead Regional Medical Center	2015-03	PHASE3
NCT05554211	WITHDRAWN	Breast Cancer; BRCA Mutation	Northwestern University	2022-07-12	PHASE2
NCT06060327	COMPLETED	Postpartum Hemorrhage; Blood Loss, Postoperative; Cesarean Section Complications	Cairo University	2023-10-15
NCT06587620	COMPLETED	Surgical Field Quality Improvement in Spine Surgeries	Zagazig University	2023-12-01
NCT05921071	UNKNOWN	Vaginal Hysterectomy	Wolfson Medical Center	2023-01-22
NCT07013812	COMPLETED	Cesarean Section; Blood Loss During Surgery	Combined Military Hospital Multan	2023-11-01	PHASE4
NCT07288697	COMPLETED	Spinal Disorders; Degenerative Spine Disease; Blood Loss, Surgical	Dr. Lutfi Kirdar Kartal Training and Research Hospital	2023-11-01
NCT05816668	UNKNOWN	Prostate Cancer	Instituto do Cancer do Estado de São Paulo	2023-04	PHASE3
NCT06205615	COMPLETED	Wound Bleeding	Bio 54, LLC	2024-01-24	PHASE2
NCT04803747	COMPLETED	Major Non-cardiac Surgeries	University of Manitoba	2022-02-16	PHASE4
NCT05911698	UNKNOWN	Melasma	Khadija Qenawi	2023-10-28
NCT06040853	UNKNOWN	Pharmacological Action	Dr. Lutfi Kirdar Kartal Training and Research Hospital	2023-09-30	PHASE4
NCT06648265	COMPLETED	Liposuction; Bruising; Inflammation; Skin Condition; Edema Arm; Ecchymosis; Hematoma	Total Definer Research Group	2022-01-20	PHASE4
NCT05759156	COMPLETED	Postpartum Hemorrhage; Cesarean Section Complications; Obstetric Anesthesia Problems	Dow University of Health Sciences	2023-03-20
NCT06457360	COMPLETED	Liver Cirrhosis	British University In Egypt	2023-11-15	EARLY_PHASE1
NCT04630886	TERMINATED	Skin Neoplasms	Riley McLean	2021-06-16	EARLY_PHASE1
NCT04410042	TERMINATED	Cancer of the Bone; Limb Salvage	St. Jude Children's Research Hospital	2021-01-29	PHASE3
NCT04372940	WITHDRAWN	Surgery	University of Wisconsin, Madison	2023-01	PHASE4
NCT05427513	UNKNOWN	Blood Loss, Surgical	Shaukat Khanum Memorial Cancer Hospital & Research Centre	2022-04-06	EARLY_PHASE1
NCT06707051	COMPLETED	Heavy. Mentrual Bleeding; Abormal utèrine Bleeding; Bleeding; Uterine Bleeding; Hypersensitivity Response; GI Disturbance; Agranulocytosis; Bleeding Pattern; Endometrial; Endometrial Bleeding	District Headquarters Teaching Hospital Sahiwal	2022-01-01	PHASE2; PHASE3
NCT05099276	UNKNOWN	Knee Osteoarthritis; Blood Loss; Pain, Postoperative	Campbell Clinic	2021-12-07	PHASE4
NCT04742205	COMPLETED	Cerebral Hemorrhage	Kathmandu Medical College and Teaching Hospital	2021-02-08	PHASE2; PHASE3
NCT05688111	COMPLETED	Interventional Drug in Placenta Previa	Hawler Medical University	2022-12-10
NCT06149091	Recruiting	Iatrogenic Endobronchial Bleeding	China-Japan Friendship Hospital\|The Second Affiliated Hospital of Harbin Medical University\|The First Affiliated Hospital of Nanchang University	2023-12-01	Early Phase 1
NCT06301204	COMPLETED	Tranexamic Acid; Orthognathic Surgery; Edema; Bleeding	Bezmialem Vakif University	2022-03-01
NCT06097611	Not yet recruiting	Tranexamic Acid Effect in Pediatric Polytraumatized Patients	Assiut University	2023-11	Early Phase 1
NCT05909072	UNKNOWN	Melasma	Zagazig University	2023-06	PHASE2
NCT05072873	UNKNOWN	Cesarean Section Complications	Aswan University Hospital	2021-10-01
NCT05326997	TERMINATED	Melasma	University of Nove de Julho	2023-05-01
NCT03287336	COMPLETED	Postpartum Hemorrhage	George Washington University	2018-01-02	PHASE2
NCT05841251	UNKNOWN	Intraoperative Bleeding; Coblation Turbinoplasty	Assiut University	2023-05-01
NCT06010810	UNKNOWN	Melasma	Indonesia University	2023-06-01	PHASE3
NCT07686705	COMPLETED	Rotator Cuff Tears	Konkuk University Medical Center	2022-05-18
NCT05448456	COMPLETED	Episiotomy Wound; Anemia; Early Postpartum Hemorrhage; Hemoglobin	Assuta Ashdod Hospital	2022-07-25	PHASE4
NCT05504577	COMPLETED	Total Blood Loss; Arthropathy of Knee Joint	Chang Gung Memorial Hospital	2022-03-16	PHASE4
NCT04651166	COMPLETED	Abortion; Dilation and Evacuation; Hemorrhage; Blood Loss	University of Hawaii	2022-02-15	PHASE2
NCT05397652	COMPLETED	Rotator Cuff Tears; Hemorrhage, Surgical; Shoulder Injuries	Nikola Matejcic	2021-05-24	PHASE4
NCT04724772	WITHDRAWN	Pain, Postoperative; Bruising	Northwestern University	2020-02-20	PHASE3
NCT04814433	TERMINATED	Opioid Pain Medication	NYU Langone Health	2021-03-24	PHASE4
NCT04373603	WITHDRAWN	Injection Site Bruising	University of Wisconsin, Madison	2022-07	PHASE4
NCT04488367	UNKNOWN	Hip Fractures	Community Memorial Health System	2020-07-06	EARLY_PHASE1
NCT05072860	UNKNOWN	Cesarean Section Complications	Aswan University Hospital	2021-10-01
NCT06038981	COMPLETED	Hemorrhage, Surgical; Bariatric Surgery; Tranexamic Acid	Medical University of Gdansk	2022-07-04
NCT05437822	UNKNOWN	Proximal Humeral Fracture; Surgical Treatment	Elda University Hospital	2022-06-29	PHASE4
NCT04272606	COMPLETED	Degenerative Disc Disease	Catherine R. Olinger	2020-08-01	PHASE2
NCT05947435	COMPLETED	Percutaneous Nephrolithotomy; Intraoperative Use of Tranexamic Acid	Haseki Training and Research Hospital	2022-01-01
NCT05884151	COMPLETED	Melasma	Combined Military Hospital Abbottabad	2022-11-01	PHASE1
NCT05887219	COMPLETED	Melasma	Combined Military Hospital Abbottabad	2022-11-01	PHASE1
NCT05686005	COMPLETED	Anesthesia	Ain Shams University	2022-12-03	PHASE4
NCT05248321	COMPLETED	Peptic Ulcer Hemorrhage	National Cheng-Kung University Hospital	2022-03-24
NCT05919615	COMPLETED	Knee Osteoarthritis; Blood Loss; Blood Transfusion	Damascus University	2021-07-15
NCT04650698	TERMINATED	Arthropathy Shoulder	NYU Langone Health	2021-01-07	PHASE4
NCT06280456	COMPLETED	Anterior Cruciate Ligament Reconstruction; Tranexamic Acid; Hemarthrosis, Knee	Taipei Veterans General Hospital, Taiwan	2022-09-05
NCT07759089	COMPLETED	Endobronchial Bleeding; Hemoptysis	Sheikh Zayed Federal Postgraduate Medical Institute	2022-01-03
NCT05696951	COMPLETED	Tranexamic Acid Adverse Reaction	Goztepe Prof Dr Suleyman Yalcın City Hospital	2022-01-01
NCT05439694	COMPLETED	Rectus Sheath Hematoma; Cesarean Section	Cairo University	2022-07-03	PHASE4
NCT05708690	COMPLETED	Coronary Artery Disease; Valvular Heart Disease; Surgical Blood Loss	Indonesia University	2022-10-01	PHASE4
NCT06183918	COMPLETED	Anterior Epistaxis; Tranexamic Acid	Izmir Ataturk Training and Research Hospital	2021-12-16	PHASE4
NCT03897621	COMPLETED	Coagulation; Intravascular; Rotational Thromboelastometry; Fibrinolysis; Hemorrhage; Tranexamic Acid; Total Hip Arthroplasty	Thomas Jefferson University	2019-05-20
NCT04691362	COMPLETED	Hemorrhage Postoperative; Total Blood Loss; Arthroplasty Complications	University of Liege	2021-01-01	PHASE4
NCT06246422	COMPLETED	Postoperative Complications	Tanta University	2021-12-11
NCT03923959	COMPLETED	Hip Fractures	Lancaster General Hospital	2020-02-01	PHASE3
NCT03085394	TERMINATED	Intra-Operative Injury - Other; Post Operative Hemorrhage; Tranexamic Acid	Sheba Medical Center	2017-09-01	PHASE3
NCT03216083	UNKNOWN	Pelvic Organ Prolapse	Mount Sinai Hospital, Canada	2018-01-01	PHASE3
NCT04178655	UNKNOWN	Tendon Injury - Hand	Rabin Medical Center	2019-11	EARLY_PHASE1
NCT05075200	COMPLETED	Arthroplasty, Replacement, Knee; Arthroplasty, Replacement, Hip	Sunnybrook Health Sciences Centre	2021-12-14	PHASE2
NCT05594186	COMPLETED	Intermenstrual Bleeding	Saudi German Hospital - Madinah	2019-03-01
NCT03789422	UNKNOWN	Chronic Spontaneous Urticaria	University Hospital, Grenoble	2019-12-10	PHASE4
NCT05897918	COMPLETED	Patient With Facial Erythema	Al-Azhar University	2020-08-01
NCT04386642	UNKNOWN	Meningioma	Chiang Mai University	2021-09-01	PHASE4
NCT04947514	COMPLETED	Hematoma Postoperative; Venous Thromboembolism	Montefiore Medical Center	2021-10-29	PHASE4
NCT04518163	UNKNOWN	Placenta Previa	Aswan University Hospital	2020-09-01
NCT02918201	COMPLETED	Postoperative Hemorrhage; Injuries and Wounds	St. Olavs Hospital	2020-01-01	PHASE2
NCT05082142	COMPLETED	Kidney Calculi; Urologic Diseases; Benign Prostatic Hypertrophy	Northwestern University	2021-09-17	PHASE4
NCT05453266	COMPLETED	Rotator Cuff Tears; Rotator Cuff Rupture; Tranexamic Acid; Shoulder Arthroscopy; Visual Clarity	Florence Nightingale Hospital, Istanbul	2022-01-01
NCT04635007	COMPLETED	Cesarean Section Complications; Blood Loss, Surgical; Misoprostol; Tranexamic Acid	Cairo University	2021-01-01	PHASE3
NCT02187120	COMPLETED	Wounds and Injuries; Acute Coagulopathy	Monash University	2014-07-28	PHASE3
NCT04863339	WITHDRAWN	Pituitary Tumor; Blood Loss; Surgery	University of North Carolina, Chapel Hill	2022-03	PHASE2
NCT02911831	COMPLETED	Hysterectomy; Blood Loss, Surgical	Northwestern University	2016-11	EARLY_PHASE1
NCT03778242	COMPLETED	Cesarean Section Complications	Aswan University Hospital	2019-01-01
NCT03801122	COMPLETED	Hematological Malignancies Treated With Intensive Chemotherapy	Centre Hospitalier Universitaire de Saint Etienne	2019-03-05	PHASE2
NCT04754230	COMPLETED	Chronic Sinusitis; Nasal Obstruction; Turbinate; Hypertrophy Mucous Membrane; Deviated Nasal Septum - Congenital; Deviated Nasal Septum Acquired	Stanford University	2021-06-17	PHASE4
NCT03136445	COMPLETED	Hematologic Neoplasms; Hemorrhage; Hematopoietic Stem Cell Transplantation	NHS Blood and Transplant	2015-06	PHASE3
NCT04319614	COMPLETED	Robotic-assisted Radical Prostatectomy	University Hospital Hradec Kralove	2020-02-24	PHASE4
NCT04771923	COMPLETED	Bleeding; Hemoptysis	Clinical Hospital Centre Zagreb	2021-02-22
NCT04710017	COMPLETED	Uterine Bleeding	Assiut University	2021-02-01
NCT03361345	WITHDRAWN	Postinflammatory Hyperpigmentation	Wayne State University	2018-11-01	PHASE2; PHASE3
NCT05855590	UNKNOWN	Burns	Instituto Mexicano del Seguro Social	2022-01-01	PHASE3
NCT03738527	UNKNOWN	Seroma Complicating A Procedure; Hematoma Postoperative; Breast Cancer	Hamilton Health Sciences Corporation	2019-10-07	PHASE4
NCT05705336	COMPLETED	Tranexamic Acid (TXA); Prospective Study; Evidence-based Medicine; Randomized Controlled Trial	Alejandro Reyes Sánchez	2021-01-01	PHASE4
NCT03774706	UNKNOWN	Cesarean Section Complications	Aswan University Hospital	2019-01-01
NCT04541303	COMPLETED	Postoperative Wound Haemorrhage	University of Missouri-Columbia	2020-10-08	EARLY_PHASE1
NCT04338126	WITHDRAWN	COVID19	University of Alabama at Birmingham	2021-09-30	PHASE2
NCT04733157	COMPLETED	Postpartum Hemorrhage	University of Zimbabwe	2021-03-23	PHASE3
NCT04907812	UNKNOWN	Hand Injuries and Disorders; Distal Radius Fracture; Dupuytren Contracture	Ruby Grewal	2021-06-01	PHASE4
NCT05362500	COMPLETED	Melasma	Combined Military Hospital Abbottabad	2021-06-01	PHASE1
NCT04622397	UNKNOWN	Blood Loss, Surgical; Scoliosis	Cairo University	2021-01-10
NCT04089865	COMPLETED	Blood Loss; Blood Transfusion	Hospital for Special Surgery, New York	2019-09-17	PHASE4
NCT05152186	UNKNOWN	Blood Loss	Minia University	2021-06-01	PHASE3
NCT04494126	UNKNOWN	Blood Loss	College of Medical Sciences Teaching Hospital. Nepal	2021-08-15	PHASE4
NCT04427618	COMPLETED	Postpartum Hemorrhage; Tranexamic Acid	KK Women's and Children's Hospital	2020-06-23	PHASE3
NCT04594408	COMPLETED	Rotator Cuff Injuries; Rotator Cuff Tears; Subacromial Impingement; Subacromial Impingement Syndrome	Panam Clinic	2020-09-01	PHASE4
NCT03782350	COMPLETED	Homeostasis; Cardiac Surgery	Chinese Academy of Medical Sciences, Fuwai Hospital	2018-12-26	PHASE4
NCT05326139	COMPLETED	Ecchymosis; Eyelid; Edema; Rhinoplasty	Baskent University	2021-06-07	PHASE4
NCT02972294	TERMINATED	Hip Fractures Pathologic; Anemia	University Hospital, Angers	2017-03-31	PHASE3
NCT04400916	UNKNOWN	Subconjunctival Hemorrhage	Rambam Health Care Campus	2020-09
NCT04549012	UNKNOWN	Effect of Drug	Ain Shams University	2020-09	EARLY_PHASE1
NCT04694677	UNKNOWN	Myoma	Aljazeera Hospital	2021-01-10
NCT03870256	COMPLETED	Post Partum Hemorrhage	Aswan University Hospital	2019-04-01
NCT05518279	WITHDRAWN	Hip Fractures; Blood Loss	Henry Ford Health System	2019-09	PHASE3
NCT04274335	COMPLETED	Pregnancy, High Risk	London School of Hygiene and Tropical Medicine	2020-12-18	PHASE2
NCT03570710	COMPLETED	Cesarean Section Complications	Aswan University Hospital	2018-01-01
NCT03606109	COMPLETED	Tibial Tubercle Osteotomy	NYU Langone Health	2018-06-26	PHASE4
NCT04338074	TERMINATED	COVID-19	University of Alabama at Birmingham	2020-06-01	PHASE2
NCT02797119	COMPLETED	Pregnancy Complications; Hemorrhage	University Hospital, Lille	2016-03-15	PHASE4
NCT04054687	SUSPENDED	Epistaxis	Mercy Health Ohio	2019-11-07	PHASE2
NCT03880604	UNKNOWN	Myoma	Aswan University Hospital	2019-04-01
NCT03777878	UNKNOWN	Cesarean Section Complications	Aswan University Hospital	2019-01-01
NCT03880045	UNKNOWN	Myoma	Aswan University Hospital	2019-04-01
NCT04911413	COMPLETED	Cardiac Surgical Procedures; Blood Transfusion; Tranexamic Acid	Chinese Academy of Medical Sciences, Fuwai Hospital	2017-09-01	PHASE4
NCT03211286	COMPLETED	Hip Fractures; Anemia	Alejandro Lizaur-Utrilla, PhD, MD	2018-01-30	PHASE4
NCT03353259	TERMINATED	Chronic Subdural Hematoma	Oslo University Hospital	2017-11-28	PHASE2; PHASE3
NCT04707950	UNKNOWN	Postpartum Hemorrhage	Benha University	2020-01-01	PHASE1; PHASE2
NCT03846973	COMPLETED	Tranexamic Acid	Hamad Medical Corporation	2018-12-02	PHASE3
NCT03863964	COMPLETED	Postpartum Hemorrhage	Brigham and Women's Hospital	2019-06-01	EARLY_PHASE1
NCT03780894	COMPLETED	Polytrauma; Traumatic Hemorrhage	Banc de Sang i Teixits	2018-11-21	PHASE1; PHASE2
NCT01869413	COMPLETED	Bladder Cancer	Ottawa Hospital Research Institute	2013-06	PHASE2; PHASE3
NCT04149171	COMPLETED	Hemorrhagic Shock	Cristina Martinez	2018-09-26	PHASE3
NCT04653623	UNKNOWN	Osteoarthritis, Knee	The Catholic University of Korea	2019-10-01
NCT02930941	TERMINATED	Epistaxis	University of California, Davis	2016-02	PHASE4
NCT03774524	UNKNOWN	Cesarean Section Complications	Aswan University Hospital	2019-01-01
NCT04357015	UNKNOWN	Myomectomy	Cairo University	2020-05-01	PHASE4
NCT04358965	UNKNOWN	Myomectomy	Cairo University	2020-05-10	PHASE4
NCT04443920	COMPLETED	Blood Loss, Surgical	The Miriam Hospital	2019-10-29	PHASE4
NCT02840097	COMPLETED	Brain Injuries; Wounds and Injuries; Hemorrhage	Daniel Nishijima, MD, MAS	2019-03-04	PHASE2
NCT04290013	UNKNOWN	Dysfunctional Uterine Bleeding	Cairo University	2020-04-22	PHASE3
NCT04357002	UNKNOWN	Myomectomy	Cairo University	2020-04-30	PHASE4
NCT04656067	COMPLETED	Blood Loss, Surgical; Blood Loss, Postoperative	Egymedicalpedia	2020-04-01	PHASE1; PHASE2
NCT03806556	TERMINATED	Pediatric Cancer; Thrombocytopenia; Hemostatic Disorder; Coagulation Defect; Acquired	Meghan McCormick	2019-04-22	PHASE1; PHASE2
NCT03697681	COMPLETED	Posterior Lumbar Spinal Fusion Surgery	Yonsei University	2018-10-16
NCT03623789	UNKNOWN	Hip Replacement, Total	Chang Gung Memorial Hospital	2018-08-15	PHASE4
NCT04419246	UNKNOWN	Nerve Block; Tranexamic Acid	Bursa Yuksek Ihtisas Training and Research Hospital	2020-07-15
NCT04055194	UNKNOWN	Placenta Previa	Ain Shams University	2019-08-01	PHASE2; PHASE3
NCT04505748	COMPLETED	Arthroplasty Complications; Total Knee Arthroplasty	University Hospital, Alexandroupolis	2020-01-01
NCT03044184	UNKNOWN	Stroke Hemorrhagic; Intracerebral Haemorrhage	Kwong Wah Hospital	2017-04-01	PHASE3
NCT03710317	COMPLETED	Cesarean Section Complications	Aswan University Hospital	2018-12-01
NCT04188184	COMPLETED	Intraoperative Bleeding	Assiut University	2019-12-04
NCT01622946	COMPLETED	Total Hip Arthroplasty; Postoperative Blood Loss	Universitaire Ziekenhuizen KU Leuven	2012-04	PHASE4
NCT03710304	COMPLETED	Cesarean Section Complications	Aswan University Hospital	2018-11-01
NCT02825719	TERMINATED	Fibroid	Queen Mary Hospital, Hong Kong	2015-12-02	PHASE4
NCT03710330	COMPLETED	Cesarean Section Complications	Aswan University Hospital	2018-11-01	PHASE4
NCT04100447	COMPLETED	Adhesions; Ileus	Ronald Hurst, MD, FACS	2018-11-05	PHASE1
NCT03413891	TERMINATED	Tooth Extraction	Universitaire Ziekenhuizen KU Leuven	2018-02-07	PHASE4
NCT04697992	COMPLETED	Periorbital Hyperpigmentation	Kasr El Aini Hospital	2019-11-01
NCT03631355	COMPLETED	Anterior Cruciate Ligament Reconstruction	NYU Langone Health	2018-06-06	PHASE4
NCT02578901	COMPLETED	Thrombocytopenia	University of Washington	2016-06	PHASE3
NCT03838328	UNKNOWN	Thromboses, Deep Vein; Tranexamic Acid Adverse Reaction	SHI Jia	2019-03-01	PHASE4
NCT02125890	COMPLETED	Abdominal Aortic Aneurysms	Saskatchewan Health Authority - Regina Area	2014-07	PHASE3
NCT03892668	COMPLETED	Myomectomy	Cairo University	2019-04-30	PHASE4
NCT03963466	COMPLETED	Melasma	xjpfW	2019-05-01
NCT03646474	COMPLETED	Cytoreductive Surgery	Assiut University	2018-08-30
NCT03742947	COMPLETED	Postpartum Hemorrhage; Hyperfibrinolysis	University Hospital, Bordeaux	2019-01-10
NCT03632824	COMPLETED	Vaginal Bleeding During Pregnancy	Hawler Medical University	2016-02-01
NCT03856164	COMPLETED	Post Partum Hemorrhage; Fibrinolysis; Hemorrhage; Blood Loss	University of Texas Southwestern Medical Center	2019-06-17	PHASE2; PHASE3
NCT01094977	SUSPENDED	Craniosynostoses	The Hospital for Sick Children	2010-01	PHASE3
NCT04628676	COMPLETED	Rotator Cuff Tears	Haseki Training and Research Hospital	2017-02-01
NCT03934047	UNKNOWN	Total Knee Arthroplasty	Second Affiliated Hospital, Zhejiang University, School of Medicine	2019-04-26
NCT04085575	COMPLETED	Postoperative Hemorrhage	Centre Hospitalier de Montauban	2019-01-01	PHASE4
NCT03069859	UNKNOWN	Post Partum Hemorrhage	Sunnybrook Health Sciences Centre	2018-03-06	PHASE2
NCT03795649	UNKNOWN	Hemorrhage	Sisters of Mercy University Hospital	2018-12-18
NCT03820206	COMPLETED	Intraoperative Bleeding	Cairo University	2019-01-31
NCT03580590	UNKNOWN	Hypotension on Induction	Assiut University	2018-09-01	EARLY_PHASE1
NCT02086500	COMPLETED	Traumatic Hemorrhage	Jason Sperry	2015-07	PHASE3
NCT03425799	TERMINATED	Spinal Fusion	Exela Pharma Sciences, LLC.	2018-10-17	PHASE3
NCT04224116	COMPLETED	Bleeding	University Tunis El Manar	2014-01-01	PHASE4
NCT03899233	UNKNOWN	Melasma	Cairo University	2019-04-01	PHASE4
NCT01402882	COMPLETED	Traumatic Brain Injury	London School of Hygiene and Tropical Medicine	2012-07	PHASE3
NCT03970213	UNKNOWN	Bleeding; Bruising Face; Swelling Lips & Face	Glasgold Group Plastic Surgery	2019-05-30	PHASE4
NCT03965767	UNKNOWN	Chronic Sinus Disease; Nasal Polyps	Ain Shams University	2019-04-25	PHASE3
NCT03885895	UNKNOWN	Therapeutic Efficacy	Kasr El Aini Hospital	2019-01-15	PHASE1
NCT01060176	UNKNOWN	Hemostasis	Chinese Academy of Medical Sciences, Fuwai Hospital	2010-02
NCT03686787	UNKNOWN	Melasma	Laser and Skin Surgery Center of New York	2018-10-01	PHASE4
NCT02684812	COMPLETED	Subarachnoid Hemorrhage	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2012-07-16	PHASE2; PHASE3
NCT01658124	COMPLETED	Gastrointestinal Bleeding	London School of Hygiene and Tropical Medicine	2013-07	PHASE3
NCT03365999	COMPLETED	Knee Osteoarthritis; Blood Clot; Transfusion Related Complication; Blood Loss	Universidad Autonoma de Nuevo Leon	2017-10-15	PHASE2
NCT03765021	UNKNOWN	Post Inflammatory Hyperpigmentation	Cairo University	2018-12
NCT03359525	UNKNOWN	Tranexamic Acid Adverse Reaction	Albany Medical College	2017-07-01	PHASE4
NCT04042688	UNKNOWN	Anterior Cruciate Ligament Rupture	Korea University Guro Hospital	2017-07-01	PHASE4
NCT02650791	COMPLETED	Hematologic Neoplasms	Ottawa Hospital Research Institute	2016-10	PHASE3
NCT03074994	UNKNOWN	Osteoarthritis,Knee	Thammasat University	2016-10	PHASE2
NCT03326596	WITHDRAWN	Postpartum Hemorrhage	United States Naval Medical Center, San Diego	2018-04-20	PHASE4
NCT02966236	UNKNOWN	Nephrolithiasis; Staghorn Calculus	University of Sao Paulo	2016-06	PHASE4
NCT04560465	COMPLETED	To Determine Efficacy of Tranexamic Acid in Reducing Blood Loss During Myomectomy	Alex Ekwueme Federal University Teaching Hospital	2018-06-01	PHASE2
NCT03386656	COMPLETED	Osteoarthritis, Knee	Fundación Pública Andaluza Progreso y Salud	2017-11-28	PHASE3
NCT03023189	UNKNOWN	Upper Digestive Bleeding; Cirrhosis	Assistance Publique - Hôpitaux de Paris	2017-04-03	PHASE4
NCT03565276	COMPLETED	Post Partum Hemorrhage	Mount Sinai Hospital, Canada	2018-07-11	PHASE3
NCT03458468	COMPLETED	Anterior Shoulder Instability	Sports Surgery Clinic, Santry, Dublin	2018-03-01
NCT03070847	UNKNOWN	Bleeding Reduction	Bartłomiej Wódarski	2017-03-01	PHASE4
NCT07261930	COMPLETED	Femoral Fractures; Hemorrhage, Surgical; Tranexamic Acid Use	Masaka Regional Referral Hospital	2018-10-01	PHASE4
NCT03433144	WITHDRAWN	Tranexamic Acid; Orthognathic Surgery	Nick Emanuele	2018-06-01	PHASE4
NCT03109652	UNKNOWN	Knee Osteoarthritis	Seoul National University Hospital	2017-07-10	PHASE4
NCT02615366	UNKNOWN	Hematoma; Seroma	Ottawa Hospital Research Institute	2016-02	PHASE4
NCT02644473	WITHDRAWN	Pulmonary Embolism; Deep Vein Thrombosis; Stroke; Myocardial Infarction	Albert Einstein College of Medicine	2016-02	PHASE4
NCT02775773	COMPLETED	Post Partum Haemorrhage	Azienda U.S.L. 1 di Massa e Carrara	2018-01-30	PHASE3
NCT03463993	COMPLETED	Post Partum Hemorrhage	University of Zimbabwe	2018-04-08	PHASE3
NCT03653429	COMPLETED	Foot and Ankle Surgeries; Bunion	Icahn School of Medicine at Mount Sinai	2018-03-01	PHASE4
NCT03011866	UNKNOWN	Spinal Stenosis; Intervertebral Disc Displacement	Peking Union Medical College Hospital	2017-02
NCT02540226	COMPLETED	Osteoarthritis, Knee	Hospital for Special Surgery, New York	2015-11-19	PHASE4
NCT02625948	UNKNOWN	Intracerebral Hemorrhage; Stroke	Ministry of Science and Technology of the People´s Republic of China	2015-09	PHASE2
NCT02936661	UNKNOWN	Postpartum Hemorrhage， Cesarean Section	Shanghai First Maternity and Infant Hospital	2017-04	PHASE4
NCT01940536	WITHDRAWN	Hip Fracture; Blood Loss	Hospital for Special Surgery, New York	2015-12	PHASE4
NCT02627560	COMPLETED	Postoperative Hemorrhage; Breast Neoplasms; Seroma	St. Olavs Hospital	2016-01	PHASE4
NCT03139422	UNKNOWN	Menorrhagia	Assiut University	2017-07-01	PHASE3
NCT03376061	COMPLETED	Bleeding; Surgical Blood Loss	Population Health Research Institute	2017-12-21	PHASE4
NCT03310060	UNKNOWN	Total Blood Loss	Chang Gung Memorial Hospital	2017-11-01	PHASE4
NCT03690037	COMPLETED	Primary Total Knee Arthroplasty; Primary Total Hip Arthroplasty	Belfast Health and Social Care Trust	2016-07-07	PHASE4
NCT02702128	COMPLETED	Peri-operative Hemorrhage or Hematoma; Surgery; Retrognathism	University Hospital, Lille	2016-01-03	PHASE3
NCT05204056	COMPLETED	Pain, Postoperative; Blood Loss, Postoperative	Yantai Yuhuangding Hospital	2018-03-02
NCT01937559	COMPLETED	Osteoarthritis; Hip Arthropathy; Shoulder Arthropathy	The Hawkins Foundation	2013-04	PHASE4
NCT03580018	COMPLETED	Anterior Cruciate Ligament Reconstruction	Taipei Veterans General Hospital, Taiwan	2017-06-01
NCT02903017	COMPLETED	Gastrointestinal Hemorrhage; Tranexamic Acid; Emergency Department; Antifibrinolytic Agents	Kocaeli University	2016-09	PHASE4
NCT03101124	COMPLETED	Surgical Wound; Bleeding	St. Olavs Hospital	2017-05-01	PHASE2
NCT04025736	COMPLETED	Rotator Cuff Tears; Shoulder Arthorscopy Surgery; Surgical Blood Loss; Tranexamic Acid	National Cheng-Kung University Hospital	2017-06-07
NCT03112135	UNKNOWN	Intraoperative Bleeding	Assiut University	2017-04	PHASE2
NCT01728636	COMPLETED	Curvature of Spine	Northwestern University	2013-01-15	PHASE2
NCT01980355	COMPLETED	Tranexamic Acid; Cancer; Major Surgery	Corewell Health West	2012-06-12
NCT03008655	UNKNOWN	Melasma	Taipei Medical University WanFang Hospital	2017-01
NCT02922582	TERMINATED	Total Knee Arthroplasty	Pacira Pharmaceuticals, Inc	2016-10-28	PHASE2
NCT02030821	COMPLETED	Blood Loss; Hip Arthritis; Knee Arthritis	Duke University	2015-01	PHASE4
NCT02864095	UNKNOWN	Blood Loss	Southwest Hospital, China	2015-05
NCT02618382	COMPLETED	Subdural Hematoma	St. Joseph's Hospital and Medical Center, Phoenix	2015-11-01	PHASE4
NCT03122782	UNKNOWN	Surgical Blood Loss; Fibroid	Ain Shams University	2017-08-01	PHASE3
NCT02733952	UNKNOWN	Post Operative Hemorrhage	Ain Shams Maternity Hospital	2015-08	PHASE3
NCT02865174	UNKNOWN	Osteoarthritis, Knee	Chang Gung Memorial Hospital	2016-09	PHASE4
NCT03244423	COMPLETED	Postoperative Hemorrhage	Assiut University	2009-01	PHASE2
NCT02535949	COMPLETED	Hemorrhage; Shock; Wounds and Injuries	Washington University School of Medicine	2016-02	PHASE2
NCT03351686	COMPLETED	Postpartum Hemorrhage	Mansoura University	2016-08-01	PHASE2; PHASE3
NCT02656472	COMPLETED	Pediatric Cardiac Surgery; Complication of Extracorporeal Circulation	Wake Forest University Health Sciences	2016-02	PHASE4
NCT03656445	COMPLETED	Osteo Arthritis Knee	Democritus University of Thrace	2015-10-01
NCT02319915	COMPLETED	Knee Prosthesis	Brugmann University Hospital	2015-02-18	EARLY_PHASE1
NCT02738073	UNKNOWN	Hip Fracture	Rothman Institute Orthopaedics
NCT02302456	COMPLETED	Immediate Postpartum Hemorrhage	University Hospital, Angers	2015-02	PHASE3
NCT03044041	COMPLETED	Blood Loss, Surgical	Thammasat University	2016-01	PHASE4
NCT02051686	COMPLETED	Acetabulum Fractures	University of Missouri-Columbia	2013-06
NCT02492087	UNKNOWN	Postpartum Haemorrhage	Dr Meng-Li Lee	2015-08	PHASE3
NCT02587845	UNKNOWN	Bleeding; Transfusion Related Complication	Samsung Medical Center	2015-10	PHASE3
NCT01527968	UNKNOWN	Osteoarthritis	Heekin Orthopedic Research Institute	2012-04
NCT01846507	COMPLETED	Heavy Menstrual Bleeding	Nationwide Children's Hospital	2013-04	PHASE4
NCT01866943	TERMINATED	Post Operative Blood Loss	Northwell Health	2011-11	PHASE2
NCT02553122	WITHDRAWN	Arthroplasty, Replacement, Knee	Montefiore Medical Center	2015-10	PHASE3
NCT02229292	COMPLETED	Intraoperative Bleeding; Postoperative Edema	Esbjerg Hospital - University Hospital of Southern Denmark	2014-08-19	PHASE4
NCT02780245	COMPLETED	Hemorrhage of Cesarean Section and/or Perineal Wound; Postpartum Hemorrhage; Uterine Atony	Talkha Central Hospital	2016-06	PHASE4
NCT02580227	UNKNOWN	Hip Fractures; Surgical Blood Loss	Good Samaritan Regional Medical Center, Oregon	2015-06	PHASE4
NCT03825939	TERMINATED	Blood Loss	NYU Langone Health	2015-04-21	PHASE4
NCT02684851	COMPLETED	Acetabular Fractures	Wake Forest University Health Sciences	2012-10	PHASE3
NCT02561923	COMPLETED	Healthy	Janssen Scientific Affairs, LLC	2015-08-27	PHASE1
NCT00872469	COMPLETED	Postpartum Haemorrhage	London School of Hygiene and Tropical Medicine	2009-05	PHASE3
NCT02604719	UNKNOWN	Postpartum Hemorrhage	Ahmed Alanwar	2015-11	PHASE1; PHASE2
NCT02453802	UNKNOWN	Osteoarthritis, Knee	Chang Gung Memorial Hospital	2015-06	PHASE4
NCT01813058	COMPLETED	Adolescent Idiopathic Scoliosis	Boston Children's Hospital	2013-01	PHASE1; PHASE2
NCT02428868	UNKNOWN	Hip Fracture; Anemia	Institut Kassab d'Orthopédie	2015-04
NCT02438566	UNKNOWN	Osteoarthritis; Blood Loss, Surgical; Blood Loss, Postoperative	The New England Baptist Hospital	2015-04	PHASE3
NCT02579941	COMPLETED	Hyperfibrinolysis	Brugmann University Hospital	2015-11
NCT02180321	COMPLETED	Craniosynostosis Patients Undergoing Distraction Osteotomy	Yonsei University	2013-06
NCT02688127	COMPLETED	Postpartum Haemorrage Sever Bleeding After Delivery	Medical Research Council	2015-08	PHASE1; PHASE2
NCT02056444	COMPLETED	Osteoarthritis	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	2014-02
NCT01496196	UNKNOWN	Hemoptisis	Meir Medical Center	2012-01	PHASE3
NCT02252497	COMPLETED	Hip Arthroplasty	Centre Hospitalier Universitaire de Saint Etienne	2014-04	PHASE4
NCT01940523	COMPLETED	Osteoarthritis	Hospital for Special Surgery, New York	2013-05	PHASE4
NCT01873768	COMPLETED	Osteoarthritis	Miller Orthopedic Specialists	2014-01	PHASE4
NCT02546648	COMPLETED	Atherosclerotic Disease; Perioperative Bleeding	McMaster University	2015-02	PHASE3
NCT01714336	COMPLETED	Hip Fracture	Mayo Clinic	2012-09	PHASE4
NCT02312440	COMPLETED	Blood Loss	Shanghai Jiao Tong University School of Medicine	2014-10	PHASE3
NCT02026297	TERMINATED	Postpartum Hemorrhage	Brigham and Women's Hospital	2014-07	PHASE2
NCT01854476	UNKNOWN	Bleeding; Coagulopathy	Sion Microtec Ltd.	2013-10	PHASE2; PHASE3
NCT02584725	COMPLETED	Arthropathy of Hip; Arthropathy of Knee	Columbia University	2014-12	PHASE4
NCT02122679	WITHDRAWN	Heart Defect, Congenital	Emory University	2014-12	PHASE4
NCT02427412	COMPLETED	Blood Loss; Postoperative Blood Loss; Thromboembolic Complications	Hvidovre University Hospital	2014-01	PHASE4
NCT02146456	COMPLETED	Avascular Necrosis of Femoral Head; Degenerative Arthritis of Hip	Seoul National University Bundang Hospital	2014-05
NCT02063035	COMPLETED	Lumbar Spinal Stenosis; Thoracic Spinal Stenosis	Massachusetts General Hospital	2012-08	PHASE4
NCT02286973	UNKNOWN	Degenerative Arthritis	Seoul National University Hospital	2014-11	PHASE1
NCT02350179	UNKNOWN	Hemorrhage of Cesarean Section and/or Perineal Wound	Ain Shams University	2014-06	PHASE1; PHASE2
NCT02071316	UNKNOWN	Upper Gastrointestinal Bleeding; Hexacapron; Hemostasis; Rebleeding; Mortality	Shaare Zedek Medical Center	2014-04
NCT02153593	TERMINATED	Blood Loss; Bone Tumour	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	2013-03	PHASE3
NCT02279186	UNKNOWN	Bleeding	Ain Shams Maternity Hospital	2014-09	PHASE4
NCT02496364	WITHDRAWN	Lumbar Disc Degeneration; Surgical Procedure, Unspecified	Vinicius Magno da Rocha, MD, MSc	2014-03-01
NCT02422056	COMPLETED	Cleft Palate; Hemorrhage	Professor Fernando Figueira Integral Medicine Institute	2013-12	PHASE4
NCT01651182	COMPLETED	Cancer; Tumour; Surgery	Sunnybrook Health Sciences Centre	2014-03	PHASE3
NCT02152917	UNKNOWN	Knee Osteoarthritis	University of Sao Paulo General Hospital	2014-02	PHASE4
NCT02327117	COMPLETED	Knee Arthroplasty, Total	Isfahan University of Medical Sciences	2013-01
NCT01894334	UNKNOWN	Acute Aortic Dissection	Beijing Anzhen Hospital	2013-04
NCT01964781	COMPLETED	Pain, Postoperative; Postoperative Hemorrhage	St. Olavs Hospital	2013-08	PHASE4
NCT01683747	TERMINATED	Shock; Sepsis; Hypotension; Critical Illness	San Diego Veterans Healthcare System	2012-06	PHASE2
NCT01089140	TERMINATED	Non-idiopathic Scoliosis	The Hospital for Sick Children	2014-11	PHASE2
NCT02374398	COMPLETED	Blood Loss	Eastern Maine Medical Center	2011-03	PHASE4
NCT01408030	COMPLETED	Telangiectasia, Hereditary Hemorrhagic; Epistaxis	James Gossage	2011-08	PHASE2
NCT02458729	COMPLETED	Osteoarthritis, Knee	Chang Gung Memorial Hospital	2012-08	PHASE4
NCT02094066	UNKNOWN	Hemorrhage	TC Erciyes University	2014-03	PHASE4
NCT01636414	COMPLETED	Total Joint Arthroplasty	OrthoCarolina Research Institute, Inc.	2012-05	PHASE4
NCT02084342	UNKNOWN	Idiopathic Scoliosis	Liu Weifeng	2013-12
NCT01258010	COMPLETED	Neurosurgery; Orthopedic Surgery; Red Blood Cell Transfusion	Centre hospitalier de l'Université de Montréal (CHUM)	2011-04
NCT00904709	COMPLETED	Menorrhagia	K. Sue Robinson	2009-10-19	PHASE4
NCT03019198	COMPLETED	Blood Loss, Surgical; Tranexamic Acid Adverse Reaction; Hip Replacement	Instituto Nacional de Traumatologia e Ortopedia	2013-12	PHASE4
NCT01643135	COMPLETED	Bleeding	Mahidol University	2012-06	PHASE4
NCT02747615	COMPLETED	Revision Total Hip Arthroplasty (RTHA)	Ain Shams University	2010-08	PHASE4
NCT02829346	COMPLETED	Osteoarthritis, Knee	Thammasat University	2012-10	PHASE2
NCT01167764	WITHDRAWN	Hemoptysis	Seoul National University Hospital	2011-07	PHASE3
NCT01655641	UNKNOWN	Gastric Cancer; Pancreatic Cancer; Hepatocellular Cancer; Colon Cancer	Tribhuvan University Teaching Hospital, Institute Of Medicine.	2012-07	PHASE2; PHASE3
NCT01428713	COMPLETED	Menorrhagia	Baylor College of Medicine	2011-08
NCT01248104	COMPLETED	Cardiopulmonary Bypass	Loma Linda University	2010-03
NCT01221909	UNKNOWN	Nasolacrimal Tract Obstruction	HaEmek Medical Center, Israel	2010-12
NCT01800435	COMPLETED	Hereditary Factor VIII Deficiency Disease With Inhibitor	Oslo University Hospital	2011-10	PHASE4
NCT00958581	COMPLETED	Scoliosis	NYU Langone Health	2008-12	PHASE4
NCT01370460	COMPLETED	Acute Blood Loss Anemia; Osteoarthritis, Knee	Henry Ford Health System	2011-06	PHASE2
NCT00740116	COMPLETED	Ovarian Cancer	Preben Kjolhede, MD, professor	2008-03	PHASE4
NCT00722436	TERMINATED	Craniosynostosis; Bleeding	University of Pittsburgh	2008-07	PHASE4
NCT01600599	COMPLETED	Post CABG Bleeding	University of Malaya	2011-01
NCT01111669	COMPLETED	Chronic Rhinosinusitis With Polyposis; Chronic Hyperplastic Sinusitis	University of Alberta	2009-08
NCT01295294	COMPLETED	Uterine Hemorrhage	Bayer	2011-03	PHASE4
NCT01306370	COMPLETED	Knee Arthropathy	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	2010-06	PHASE3
NCT01191554	COMPLETED	Hemorrhage; Valvular Heart Surgery	Chinese Academy of Medical Sciences, Fuwai Hospital	2010-09
NCT01338454	COMPLETED	Obstetrical Hemorrhage	Erzincan Military Hospital	2011-03	PHASE3
NCT01190150	COMPLETED	Menorrhagia	Ferring Pharmaceuticals	2010-08	PHASE4
NCT01850394	COMPLETED	Primary Osteoarthritis of Knee Nos	Mahidol University	2010-01
NCT00809393	COMPLETED	Cardiopulmonary Bypass; Hemorrhage	Hopital Foch	2009-02	PHASE4
NCT01228136	COMPLETED	Tonsillectomy; Adenoidectomy; Tranexamic Acid	Irmandade Santa Casa de Misericórdia de Porto Alegre	2010-01	PHASE4
NCT01067638	COMPLETED	Coronary Artery Occlusive Disease	Yonsei University	2009-11	PHASE4
NCT01085006	COMPLETED	Hemorrhage	Tehran University of Medical Sciences	2009-09	PHASE1; PHASE2
NCT00824564	COMPLETED	Femoral Fractures	Pfizer	2009-04	PHASE4
NCT00375258	COMPLETED	Hemorrhage	London School of Hygiene and Tropical Medicine	2005-05	PHASE3
NCT00755209	COMPLETED	Brain Injuries	Khon Kaen University	2008-10	PHASE3
NCT00985920	COMPLETED	Surgical Blood Loss; Total Knee Arthroplasty	University Health Network, Toronto	2007-09	PHASE4
NCT00671281	WITHDRAWN	Chronic Sinusitis	University of Calgary	2008-10
NCT00113568	COMPLETED	Menorrhagia; Heavy Menstrual Bleeding	Ferring Pharmaceuticals	2005-06	PHASE3
NCT01280981	COMPLETED	Menorrhagia	Ferring Pharmaceuticals	2007-04	PHASE3
NCT00375466	COMPLETED	Hemorrhage	St. Olavs Hospital	2006-09
NCT01027546	COMPLETED	Cervical Myelopathy	Yodakubo Hospital	2007-01
NCT00386308	COMPLETED	Menorrhagia; Heavy Menstrual Bleeding	Ferring Pharmaceuticals	2006-10	PHASE3
NCT00401193	COMPLETED	Menorrhagia; Heavy Menstrual Bleeding	Ferring Pharmaceuticals	2006-11	PHASE3
NCT00588133	COMPLETED	Cardiac Surgery	Mayo Clinic	2004-01	PHASE3
NCT00994994	COMPLETED	Blood Loss; Congenital Heart Disease	Okayama University	2006-01
NCT00327106	COMPLETED	Hip Fracture	Centre Hospitalier Universitaire de Saint Etienne	2005-04	PHASE3
NCT00500656	COMPLETED	Hereditary Angioedema	Shire	2005-03-01	PHASE3
NCT00308880	UNKNOWN	Head and Neck Neoplasms	Taichung Veterans General Hospital	2006-03	PHASE3
NCT00111215	COMPLETED	Menorrhagia; Blood Coagulation Disorders; Blood Platelet Disorders; Von Willebrand Disease; Hematologic Disease	Centers for Disease Control and Prevention	2001-01
NCT00396760	UNKNOWN	Bleeding and Cardiac Surgery; Allogeneic Blood Transfusion; Aortic Valve Replacement; Coronary Artery Bypass Graft Surgery	German Heart Center	2005-01	PHASE3

(data from https://clinicaltrials.gov, updated on 2025-12-15)

Check the Tranexamic Acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Tranexamic acid functions as an antifibrinolytic agent by competitively binding to the lysine-binding sites of plasminogen and plasmin with an IC50 of 5 mM, thereby inhibiting plasmin interaction with fibrin and preventing elastase-derived plasminogen fragment activation. This molecular blockade prevents the enzymatic breakdown of fibrin networks to preserve blood clot integrity, which directly mediates its therapeutic efficacy in reducing intraoperative bleeding, surgical blood loss, and postpartum hemorrhage.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).