Trametinib (GSK1120212) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

Product Name: Trametinib (GSK1120212)
Catalog Number: S2673
CAS Number: 871700-17-3
IUPAC Name: N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide

Relevant identified uses and uses advised against

Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

Company : Selleck Chemicals
TollFree : +1 877 796-6397
Tel : +1 832 582-8158
Fax : +1 832 582-8590

Emergency telephone number

Emergency phone #: +1 832 582-8158

2. HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture
This substance does not meet the classification criteria of the EC Directives 67/548/EEC, 1999/45/EC, or 1272/2008.

2.2 Label elements
The product does not require labeling in accordance with EC directives or respective national laws.

2.3 Other hazards
None.

3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances

Product Name: Trametinib
Chemical Name: N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Formula: C26H23FIN5O4
Molecular Weight: 615.4
CAS Number: 871700-17-3

4. FIRST AID MEASURES

4.1 Description of first aid measures

General Advice: Consult a physician and present this safety data sheet.
If Inhaled: Move person to fresh air and monitor breathing. If breathing is difficult, give oxygen. If breathing stops, provide artificial respiration. Consult a physician.
In Case of Skin Contact: Immediately wash skin with copious amounts of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. Consult a physician.
In Case of Eye Contact: Flush eyes with copious amounts of water for at least 15 minutes. Consult a physician.
If Swallowed: Rinse mouth with water. Do not induce vomiting unless directed by medical personnel. Never give anything by mouth to an unconscious person. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

4.3 Indication of immediate medical attention and special treatment needed
Immediate medical attention is required. Show this safety data sheet to the attending physician.

5. FIRE-FIGHTING MEASURES

5.1 Extinguishing media
Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.

5.2 Special hazards arising from the substance or mixture
In combustion, the substance may emit toxic fumes.

5.3 Precautions for fire-fighters
Wear suitable protective clothing to prevent contact with skin and eyes and a self-contained breathing apparatus.

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures
Do not take action without suitable protective clothing (see Section 8). Evacuate personnel to safe areas. Ensure adequate ventilation. Avoid breathing vapors, mist, dust, or gas.

6.2 Environmental precautions
Do not allow the product to enter drains.

6.3 Methods and materials for containment and cleaning up
Cover spillage with suitable absorbent material. Sweep up the material and place it in an appropriate container. Hold all material for appropriate disposal as described in Section 13.

6.4 Reference to other sections
For required personal protective equipment, see Section 8. For disposal instructions, see Section 13.

7. HANDLING AND STORAGE

7.1 Precautions for safe handling
Use in a chemical fume hood with air supplied by an independent system. Avoid inhalation and contact with eyes, skin, and clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.

7.2 Conditions for safe storage, including any incompatibilities
Store in a cool, well-ventilated area. Keep away from direct sunlight. Keep container tightly sealed until ready for use. Recommended storage temperature: Store at -20°C.

7.3 Specific end uses
Use in a laboratory fume hood where possible. Refer to the employer's COSHH risk assessment.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters
Contains no substances with occupational exposure limit values.

8.2 Exposure controls

Appropriate Engineering Controls: Use in a fume hood where applicable. Ensure all engineering measures described in Section 7 are in place. Ensure the laboratory is equipped with a safety shower and eye wash station.
Eye/Face Protection: Use appropriate safety glasses.
Skin Protection: Use appropriate chemical-resistant gloves (minimum requirement: standard BS EN 374:2003). Gloves should be inspected before use. Wash and dry hands thoroughly after handling.
Body Protection: Wear appropriate protective clothing.
Respiratory Protection: If a risk assessment indicates it is necessary, use a suitable respirator.

9. PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties

Appearance: White powder
Odor: N/A
Odor Threshold: N/A
pH: N/A
Melting / Freezing Point: N/A
Boiling Point / Range: N/A
Flash Point: N/A
Evaporation Rate: N/A
Flammability (solid, gas): N/A
Upper / Lower Flammability or Explosive Limits: N/A
Vapor Pressure: N/A
Vapor Density: N/A
Relative Density: N/A
Solubility(ies): Soluble to 100 mM in DMSO
Partition Coefficient: N/A
Auto-ignition Temperature: N/A
Decomposition Temperature: N/A
Viscosity: N/A
Explosive Properties: N/A
Oxidising Properties: N/A

9.2 Other safety information
N/A.

10. STABILITY AND REACTIVITY

10.1 Reactivity
Stable under recommended transport or storage conditions.

10.2 Chemical stability
Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions
Hazardous reactions will not occur under normal transport or storage conditions. Decomposition may occur on exposure to conditions or materials listed below.

10.4 Conditions to avoid
Heat, moisture.

10.5 Incompatible materials
Strong acids/alkalis, strong oxidising/reducing agents.

10.6 Hazardous decomposition products
In combustion, may emit toxic fumes. No known decomposition information.

11. TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects

Acute Toxicity: N/A.
Skin Corrosion/Irritation: Classification criteria are not met based on available data.
Serious Eye Damage/Irritation: Classification criteria are not met based on available data.
Respiratory or Skin Sensitization: Classification criteria are not met based on available data.
Germ Cell Mutagenicity: Classification criteria are not met based on available data.
Carcinogenicity: Classification criteria are not met based on available data.
Reproductive Toxicity: Classification criteria are not met based on available data.
Specific Target Organ Toxicity - Single Exposure: Classification criteria are not met based on available data.
Specific Target Organ Toxicity - Repeated Exposure: Classification criteria are not met based on available data.
Aspiration Hazard: Classification criteria are not met based on available data.

Symptoms / Routes of Exposure

Inhalation: There may be irritation of the throat with a feeling of tightness in the chest.
Ingestion: There may be irritation of the throat.
Skin: There may be mild irritation at the site of contact.
Eyes: There may be irritation and redness.
Delayed / Immediate Effects: No known symptoms.

Additional Information

RTECS No: AB6039500
Exposure may cause irritation of eyes, mucous membranes, upper respiratory tract, and skin. To the best of our knowledge, the chemical, physical, and toxicological properties have not been fully investigated.

12. ECOLOGICAL INFORMATION

12.1 Toxicity
N/A.

12.2 Persistence and degradability
N/A.

12.3 Bioaccumulative potential
N/A.

12.4 Mobility in soil
N/A.

12.5 Results of PBT and vPvB assessment
N/A.

12.6 Other adverse effects
N/A.

13. DISPOSAL CONSIDERATIONS

13.1 Waste treatment methods

Product: Transfer to a suitable container and arrange for collection by a specialized disposal company in accordance with national legislation.
Contaminated Packaging: Dispose of in a regulated landfill site or other method for hazardous or toxic wastes in accordance with national legislation.

14. TRANSPORT INFORMATION

Classified according to the criteria of the UN Model Regulations as reflected in the IMDG Code, ADR, RID, and IATA.

14.1 UN-Number
Does not meet the criteria for classification as hazardous for transport.

14.2 UN proper shipping name
Does not meet the criteria for classification as hazardous for transport.

14.3 Transport hazard class(es)
Does not meet the criteria for classification as hazardous for transport.

14.4 Packaging group
Does not meet the criteria for classification as hazardous for transport.

14.5 Environmental hazards
This product is not classified as environmentally hazardous according to the UN Model Regulations, nor a marine pollutant according to the IMDG Code.

14.6 Special precautions for users
N/A.

15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 453/2010.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
N/A

California Proposition 65
Not applicable

15.2 Chemical safety assessment
A Chemical Safety Assessment has not been made for this product.

16. OTHER INFORMATION

Revision Date: 2026/05/28
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.