Molecular Weight: 615.39 g/mol
Chemical Structure
Check the
Trametinib (GSK1120212)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(12.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(162.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(162.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(162.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
22 mg/mL
(35.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
| IUPAC Name | N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide | |
|---|---|---|
| CAS Number | 871700-17-3 | |
| Molecular Formula |
C26H23FIN5O4 |
|
| Molecular Weight (MW) | 615.39 | |
| SMILES | CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5 | |
| InChIKey | LIRYPHYGHXZJBZ-UHFFFAOYSA-N |
- Trametinib (GSK1120212) Mechanism of Action: MEK Inhibition in Melanoma Cell Research
- Trametinib (GSK1120212) Clinical Trials
- Trametinib (GSK1120212): Selectivity & Specificity
- Trametinib (GSK1120212) Working Concentration | Cell Culture | Treatment
- Trametinib (GSK1120212) Solubility in DMSO
- Trametinib (GSK1120212) Stock Solution
- Trametinib (GSK1120212) Storage
- Trametinib (GSK1120212) Stability
- Trametinib (GSK1120212) Combination Database
- Trametinib (GSK1120212) SMILES
- Trametinib (GSK1120212) CAS Number
- Trametinib (GSK1120212) Chemical Structure (2D and 3D)
- Trametinib (GSK1120212) Sigma (AMBH2D6F887E)? Try a better option.
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- Trametinib (GSK1120212) Cayman (16292)? Try a better option.
- Trametinib (GSK1120212) Cell Signaling Technology (62206)? Try a better option.
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- Trametinib (GSK1120212) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.