CAS No. 1314890-29-3
Batch:
Purity:99.00
Chemical Structure
Check the
TMP269
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[[4-(4-phenyl-1,3-thiazol-2-yl)oxan-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide | |
|---|---|---|
| CAS Number | 1314890-29-3 | |
| Molecular Formula |
C25H21F3N4O3S |
|
| Molecular Weight (MW) | 514.52 | |
| SMILES | C1COCCC1(CNC(=O)C2=CC=CC(=C2)C3=NOC(=N3)C(F)(F)F)C4=NC(=CS4)C5=CC=CC=C5 | |
| InChIKey | HORXBWNTEDOVKN-UHFFFAOYSA-N |
TMP269 is a potent and selective class IIa histone deacetylase (HDAC) inhibitor targeting HDAC4 (IC50 157 nM), HDAC5 (IC50 97 nM), HDAC7 (IC50 43 nM), and HDAC9 (IC50 23 nM). By inhibiting class IIa HDAC catalytic domain activity, TMP269 modulates histone acetylation, suppresses hypoxia-inducible factor 1α (HIF-1α) transcriptional signaling, and regulates immune cell function and gene expression profiles in cellular models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(194.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(194.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.