CAS No. 40592-88-9
Batch:
Purity:99.74
Chemical Structure
Check the
TLR4-IN-C34
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(2R,3S,4R,5R,6S)-5-acetamido-3,4-diacetyloxy-6-propan-2-yloxyoxan-2-yl]methyl acetate | |
|---|---|---|
| CAS Number | 40592-88-9 | |
| Molecular Formula |
C17H27NO9 |
|
| Molecular Weight (MW) | 389.40 | |
| SMILES | CC(C)OC1C(C(C(C(O1)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C | |
| InChIKey | KMIQMFHPUJUDMC-HHARLNAUSA-N |
TLR4-IN-C34 is a potent and selective antagonist of Toll-like receptor 4 (TLR4). By inhibiting TLR4 signaling pathways, TLR4-IN-C34 suppresses downstream NF-kB activation and reduces the expression of pro-inflammatory cytokines such as TNF-α and IL-6. Consequently, it attenuates intestinal cell apoptosis and mitigates systemic inflammation in animal models of endotoxemia and necrotizing enterocolitis. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(200.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 78 mg/mL |
| Ethanol | 78 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.