CAS No. 1315330-17-6
Batch:
Purity:99.86
Chemical Structure
Check the
TL02-59
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(6,7-dimethoxyquinazolin-4-yl)oxy-N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide | |
|---|---|---|
| CAS Number | 1315330-17-6 | |
| Molecular Formula |
C32H34F3N5O4 |
|
| Molecular Weight (MW) | 609.64 | |
| SMILES | CCN1CCN(CC1)CC2=CC=C(NC(=O)C3=CC=C(C)C(=C3)OC4=C5C=C(OC)C(=CC5=NC=N4)OC)C=C2C(F)(F)F | |
| InChIKey | AMHWQBGAKJESFB-UHFFFAOYSA-N |
TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an ICof. Selective inhibition of Fgr disrupts oncogenic non-receptor tyrosine kinase signaling pathways in myeloid hematopoietic cells. This blockade potently suppresses cell proliferation and induces growth arrest and apoptosis in acute myeloid leukemia cells, leading to a significant reduction of leukemic burden in vivo. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(164.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.