CAS No. 51322-75-9
Batch:
Purity:98.4
Chemical Structure
Check the
Tizanidine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 51322-75-9 | |
|---|---|---|
| Molecular Formula |
C9H8ClN5S |
|
| Molecular Weight (MW) | 253.71 | |
| SMILES | C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl |
Tizanidine is an imidazoline derivative that acts as a central α2-adrenergic receptor agonist. By stimulating presynaptic α2-adrenergic receptors within the spinal cord, it inhibits the release of excitatory amino acids. This mechanism downregulates polysynaptic reflex transmission in spinal interneurons, leading to reduced facilitation of spinal motor neurons and the suppression of muscle spasms and spasticity.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(197.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 15 mg/mL |
| Ethanol | 6 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.