Clinical Trials

Ticagrelor has been evaluated across numerous clinical trials spanning early- to late-stage phases, investigating a broad spectrum of cardiovascular and cerebrovascular conditions including acute coronary syndrome, myocardial infarction, ischaemic stroke, transient ischaemic attack, coronary artery disease, and thrombosis. Sponsored by industry leaders such as AstraZeneca as well as academic institutions like University Hospital Heidelberg and the University of Florida, these studies encompass recruitment statuses ranging from active recruitment to completed phases. Landmark late-stage evaluations have focused on key clinical outcomes such as vascular event prevention and post-stroke management.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07257198 RECRUITING
NSTEMI - Non-ST Segment Elevation MI; STEMI (ST Elevation MI); Myocardial Infarction
Montreal Heart Institute
 2026-03-03 PHASE3
NCT07507500 NOT_YET_RECRUITING
Myocardial Infarction (MI)
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
 2026-07 PHASE4
NCT06451198 RECRUITING
Coronary Artery Disease; Antiplatelet Drugs
Shanghai Zhongshan Hospital
 2025-05-19 PHASE4
NCT07582835 RECRUITING
Coronary Artery Disease; Percutaneous Coronary Intervention; Acute Coronary Syndromes; Antiplatelet Therapy; Single Antiplatelet Therapy; Coagulation Factors
Cardiocentro Ticino
 2026-04-20 PHASE3
NCT05476991 RECRUITING
Stroke; Stroke, Ischemic; Atherosclerosis; Myocardial Infarction; Coronary Syndrome; TIA; Cardiac Disease; Cerebral Infarction
Assistance Publique - Hôpitaux de Paris
 2023-05-17 PHASE3
NCT06714526 RECRUITING
Intracranial Atherosclerosis
Sunnybrook Health Sciences Centre
 2025-10-07
NCT06853535 RECRUITING
Acute Ischemic Stroke; Clopidogrel Resistance
Sichuan Provincial People's Hospital
 2025-05-23 PHASE3
NCT05283356 RECRUITING
Severe Aortic Valve Stenosis; Aortic Valve Stenosis; Transcatheter Aortic Valve Replacement (TAVR); Transcatheter Aortic Valve Implantation (TAVI)
Fundacin Biomedica Galicia Sur
 2022-01-21 PHASE4
NCT07613840 RECRUITING
Peripheral Arterial Disease (PAD); Amputation; Thrombosis; Thrombosis (Stent Thrombosis); Platelet Aggregation Inhibitors; Thromboelastography (TEG); PRU(Platelet Reactivity Unit)
Massachusetts General Hospital
 2025-04-29
NCT07438886 NOT_YET_RECRUITING
Healthy Volunteer
Advenchen Laboratories Nanjing Ltd.
 2026-03-02 PHASE1
NCT06981390 NOT_YET_RECRUITING
Coronary Artery Disease; Coronary Artery Bypass Grafting; Saphenous Vein; Dual Antiplatelet Therapy
Kexiang Liu, MD
 2026-05-01
NCT05047172 ACTIVE_NOT_RECRUITING
Intracranial Arteriosclerosis; Stroke
University of Florida
 2022-08-02 PHASE3
NCT04755387 RECRUITING
Acute Myocardial Infarction
Dong-A University
 2023-03-27 PHASE4
NCT05997693 RECRUITING
Chronic Coronary Disease
Weill Medical College of Cornell University
 2024-08-15 PHASE3
NCT06228456 RECRUITING
Coronary Artery Disease
University of Florida
 2024-04-01 PHASE4
NCT04937699 RECRUITING
Acute Coronary Syndrome; Percutaneous Coronary Intervention
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2023-03-28 PHASE4
NCT07203846 NOT_YET_RECRUITING
ACS - Acute Coronary Syndrome; Ticagrelor; Microbiota; Platelet Aggregation; Myocardial Infarction (MI); Blood Platelets; Drug Effects; Platelet Aggregation Inhibitors; Drug Resistance; Platelet Function Tests; Dysbiosis; Anti-Bacterial Agents; Rifaximin
Collegium Medicum w Bydgoszczy
 2026-01-01 PHASE4
NCT05681702 RECRUITING
Coronary Artery Disease
University of Florida
 2023-02-15 PHASE4
NCT07080684 NOT_YET_RECRUITING
Chronic Coronary Syndrome
University of Messina
 2025-12-01 PHASE4
NCT06756945 NOT_YET_RECRUITING
ST-elevation Myocardial Infarction (STEMI)
Beijing Anzhen Hospital
 2025-01 PHASE4
NCT06691191 RECRUITING
Coronary Artery Disease
University of Florida
 2025-01-08 PHASE4
NCT06588595 RECRUITING
Coronary Arterial Disease (CAD)
University of Florida
 2024-11-01 PHASE4
NCT06400940 RECRUITING
Intracranial Aneurysm
Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
 2023-08-17 PHASE4
NCT06486363 NOT_YET_RECRUITING
Intracranial Aneurysms; Antiplatelet Drugs
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
 2024-08-01 PHASE4
NCT04695106 RECRUITING
Atrial Fibrillation; Antithrombotic Therapy; Acute Coronary Syndrome; Percutaneous Coronary Interventions
Medical University of Gdansk
 2021-10-25 PHASE4
NCT06653348 RECRUITING
Ischemic Stroke; Transient Ischemic Attack
Mazandaran University of Medical Sciences
 2024-04-01 PHASE2; PHASE3
NCT04989257 UNKNOWN
High Ischemic Risk
Yonsei University
 2021-08
NCT04981041 COMPLETED
Acute Coronary Syndrome; Atrial Fibrillation
Ludwig-Maximilians - University of Munich
 2021-12-16 PHASE4
NCT07597239 ACTIVE_NOT_RECRUITING
Thrombosis; Arterial Occlusive Diseases; Thromboelastography (TEG); Peripheral Arterial Disease(PAD); Stent Thrombosis; Platelet Inhibition; PRU(Platelet Reactivity Unit)
Massachusetts General Hospital
 2020-11-01
NCT07268859 RECRUITING
Acute Coronary Syndromes; Ticagrelor; Dyspnea
Acibadem University
 2025-03-15
NCT05986968 ACTIVE_NOT_RECRUITING
ST Elevation Myocardial Infarction
Radboud University Medical Center
 2023-07-06
NCT06316570 COMPLETED
Ischemic Stroke, Acute
Beijing Tiantan Hospital
 2024-04-03 PHASE3
NCT06301776 UNKNOWN
Brain Disease; Vertebral Artery Stenosis
The Fourth Affiliated Hospital of China Medical University
 2023-12-05
NCT06613191 NOT_YET_RECRUITING
Coronary Arterial Disease (CAD); Peripheral Vascular Disease
Ochsner Health System
 2024-10-01 PHASE4
NCT06509893 RECRUITING
Coronary Artery Disease
Shiraz University of Medical Sciences
 2024-08-01 PHASE4
NCT04240834 RECRUITING
Acute Coronary Syndrome; Interventional Cardiology
Fu Wai Hospital, Beijing, China
 2021-02-01 PHASE4
NCT06561867 UNKNOWN
Ischemic Stroke
Kafrelsheikh University
 2024-08-30 PHASE3
NCT06591377 RECRUITING
Ischemic Stroke
Kafrelsheikh University
 2024-08-10 PHASE3
NCT06591338 RECRUITING
Ischemic Stroke
Kafrelsheikh University
 2024-09-01 PHASE3
NCT05885932 RECRUITING
Ischemic Stroke; Vertebral Artery Stenosis
Xuanwu Hospital, Beijing
 2023-08-25
NCT05183178 COMPLETED
Acute Coronary Syndrome
Vastra Gotaland Region
 2022-02-01 PHASE4
NCT05380063 COMPLETED
Coronary Artery Disease; Coronary Artery Bypass Grafting; Dual Antiplatelet Therapy; Bleeding; Myocardial Infarction; Myocardial Ischemia; Angina Pectoris
China National Center for Cardiovascular Diseases
 2023-02-14 PHASE4
NCT06015477 UNKNOWN
Intracranial Aneurysm; Stent Complication
The First Affiliated Hospital with Nanjing Medical University
 2024-01-01
NCT05149560 COMPLETED
Acute Myocardial Infarction
Vastra Gotaland Region
 2021-12-14 PHASE2
NCT06202755 UNKNOWN
Ischemic Stroke
Kafrelsheikh University
 2024-03-30 PHASE3
NCT05767723 ACTIVE_NOT_RECRUITING
Acute Coronary Syndrome
Hospital Israelita Albert Einstein
 2023-02-06 PHASE4
NCT03797651 UNKNOWN
Coronary Artery Disease, Acute Coronary Syndrome
Yonsei University
 2019-04-24
NCT03560310 ACTIVE_NOT_RECRUITING
Acute Coronary Syndrome
Vastra Gotaland Region
 2018-06-29 PHASE4
NCT06318481 COMPLETED
Stent Thrombosis; Myocardial Infarction, Acute
National Institute of Cardiovascular Diseases, Pakistan
 2024-02-19 PHASE3
NCT03476369 TERMINATED
Percutaneous Coronary Intervention
The Guthrie Clinic
 2018-04-18 PHASE4
NCT07444164 COMPLETED
Healthy
Laboratorios Silanes S.A. de C.V.
 2025-01-13 PHASE1
NCT04483583 COMPLETED
Coronary Artery Disease
University of Florida
 2020-12-08 PHASE4
NCT04255602 UNKNOWN
Acute Coronary Syndrome; Coronary Stent Implantation
Shanghai Tong Ren Hospital
 2020-02-19 PHASE4
NCT07622056 COMPLETED
Chronic Coronary Syndrome; Coronary Artery Disease; Percutaneous Coronary Intervention
Kaohsiung Veterans General Hospital.
 2024-01-03 PHASE4
NCT05779059 UNKNOWN
Non ST Segment Elevation Acute Coronary Syndrome; Non-ST-Segment Elevation Myocardial Infarction (NSTEMI); Unstable Angina
Collegium Medicum w Bydgoszczy
 2023-04-01 PHASE3
NCT06196047 UNKNOWN
Ischemic Stroke
Kafrelsheikh University
 2023-12-01 PHASE3
NCT06584812 COMPLETED
Acute Coronary Syndrome; Ischemic Stroke
Tianjin Institute of Pharmaceutical Research Co., Ltd
 2024-09-09 PHASE1
NCT06088433 UNKNOWN
Coronary Heart Disease
Fu Wai Hospital, Beijing, China
 2023-11-15 PHASE4
NCT06554821 COMPLETED
Healthy Participants
AstraZeneca
 2024-08-05 PHASE1
NCT06591390 RECRUITING
Ischemic Stroke
Kafrelsheikh University
 2022-02-09 PHASE3
NCT06671470 COMPLETED
Insomnia
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.
 2024-08-22 PHASE1
NCT06591312 RECRUITING
Ischemic Stroke
Kafrelsheikh University
 2022-05-01 PHASE3
NCT04286438 COMPLETED
Hemorrhage; Urgent Surgery; Invasive Procedure
SFJ Pharmaceuticals, Inc.
 2020-07-15 PHASE3
NCT06233266 UNKNOWN
Healthy Subjects
Bio-innova Co., Ltd
 2024-06-18 PHASE1
NCT04718025 UNKNOWN
STEMI; NSTEMI; Unstable Angina
Collegium Medicum w Bydgoszczy
 2022-02-07 PHASE3
NCT04307485 UNKNOWN
Senior Acute Coronary Syndrome Patients After PCI
Shanghai Tong Ren Hospital
 2020-03-10 PHASE4
NCT04307511 UNKNOWN
Acute Coronary Syndrome Patients With Diabetes After PCI
Shanghai Tong Ren Hospital
 2020-04-20 PHASE4
NCT03729401 TERMINATED
Coronary Artery Disease; Myocardial Infarction
Ottawa Heart Institute Research Corporation
 2019-08-22 PHASE4
NCT05831462 UNKNOWN
Ticagrelor
Assiut University
 2023-06-01 PHASE1; PHASE2
NCT06667349 COMPLETED
STEMI - ST Elevation Myocardial Infarction; Stent Thrombosis; Antiplatelet Agents
National Institute of Cardiovascular Diseases, Pakistan
 2023-08-24 PHASE4
NCT04971356 ACTIVE_NOT_RECRUITING
Antiplatelet Drug; Acute Coronary Syndrome; Angioplasty, Balloon
Xijing Hospital
 2021-11-01
NCT03551964 COMPLETED
Acute Myocardial Infarction; Cardiogenic Shock
Faculty Hospital Kralovske Vinohrady
 2018-08-01 PHASE4
NCT05209412 UNKNOWN
De Novo Stenosis; Coronary Artery Disease; Percutaneous Coronary Intervention
Xijing Hospital
 2022-02-01
NCT04442919 COMPLETED
Unstable Angina
Collegium Medicum w Bydgoszczy
 2020-06-01 PHASE4
NCT04484259 COMPLETED
Diabetes Mellitus, Type 2; Coronary Artery Disease
University of Florida
 2021-03-31 PHASE4
NCT05166538 UNKNOWN
Multi Vessel Coronary Artery Disease
Yonsei University
 2022-02-01 PHASE4
NCT05116995 UNKNOWN
Thrombosis; Myocardial Infarction
Nova Scotia Health Authority
 2021-11-01 PHASE4
NCT04738097 COMPLETED
Ischemic Stroke; Transient Ischemic Attack
Mazandaran University of Medical Sciences
 2021-08-08 PHASE3
NCT05553613 COMPLETED
Ischemic Stroke
Kafrelsheikh University
 2022-10-01 PHASE3
NCT06120725 COMPLETED
Ischemic Stroke
Kafrelsheikh University
 2021-09-01 PHASE3
NCT04976530 COMPLETED
Hemorrhage, Surgical; Blood Loss, Surgical; Blood Loss, Postoperative; Hemorrhage Postoperative
CytoSorbents, Inc
 2021-08-31
NCT03331484 COMPLETED
Atrial Fibrillation; Acute Coronary Syndrome
Ottawa Heart Institute Research Corporation
 2018-11-01 PHASE3
NCT02494895 UNKNOWN
Acute Coronary Syndrome
Yonsei University
 2015-08-01 PHASE4
NCT04927949 COMPLETED
ST-elevation Myocardial Infarction
University Hospital, Caen
 2021-06-08 PHASE4
NCT04007055 TERMINATED
Peripheral Artery Disease; Clopidogrel, Poor Metabolism of; Peripheral Vascular Disease; Artery Disease; Peripheral Arterial Occlusive Disease
Marissa Jarosinski
 2019-08-09 PHASE3
NCT05858918 COMPLETED
Stable Chronic Angina
Shiraz University of Medical Sciences
 2022-10-01
NCT05774431 Recruiting
Acute Myocardial Infarction
University Hospital Heidelberg|AstraZeneca
 2023-03-13 --
NCT03357874 COMPLETED
Acute Coronary Syndrome
Assistance Publique Hopitaux De Marseille
 2018-10-28 PHASE3
NCT05373277 UNKNOWN
Pharmacokinetics
Helsinki University Central Hospital
 2022-05-11 PHASE1
NCT05210595 UNKNOWN
Acute Myocardial Infarction; Ticagrelor
Dong-A University
 2022-01-01 PHASE4
NCT04688723 UNKNOWN
Coronary Artery Disease; Myocardial Ischemia; Myocardial Infarction; Atrial Fibrillation
Zuyderland Medisch Centrum
 2020-12-23 PHASE4
NCT04946929 UNKNOWN
Hepatic Artery Thrombosis; Liver Transplant; Complications; Pediatric Disease
RenJi Hospital
 2021-07-31 PHASE3
NCT05162131 TERMINATED
Healthy
SFJ Pharmaceuticals, Inc.
 2021-12-25 PHASE1
NCT03161678 COMPLETED
Myocardial Infarction; Thrombosis; Platelet Dysfunction
University of Maryland, Baltimore
 2017-08-22 PHASE4
NCT04091074 UNKNOWN
Carotid Stenosis
Assiut University
 2022-01-01 PHASE1
NCT04744571 UNKNOWN
Coronary Artery Disease; Coronary Occlusion; Percutaneous Coronary Intervention; Chronic Total Occlusion of Coronary Artery; Drug-Eluting Stents
Beijing Anzhen Hospital
 2021-02
NCT05093790 COMPLETED
Coronary Artery Disease; Healthy Participants
Bristol-Myers Squibb
 2022-03-25 PHASE2
NCT04293172 WITHDRAWN
Sickle Cell Disease
AstraZeneca
 2020-06-30 PHASE3
NCT04766437 COMPLETED
Non ST Segment Elevation Acute Coronary Syndrome
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2021-02-19 PHASE2
NCT05516784 COMPLETED
Coronary Artery Disease (CAD)
Universiti Sains Malaysia
 2019-09-01 PHASE4
NCT04739384 COMPLETED
Acute Coronary Syndrome; STEMI; NSTEMI; Coronary Artery Disease; Myocardial Infarction
Federico II University
 2021-04-01 PHASE3
NCT02677545 COMPLETED
Carotid Artery Stenosis
University Hospital, Basel, Switzerland
 2016-12 PHASE2
NCT04057300 COMPLETED
Acute Coronary Syndrome
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2018-10-01 PHASE4
NCT04006288 COMPLETED
Coronary Artery Disease
University of Florida
 2019-09-06 PHASE4
NCT04588727 COMPLETED
Cardiovascular Disease
AstraZeneca
 2020-10-15 PHASE1
NCT05283356 Recruiting
Severe Aortic Valve Stenosis|Aortic Valve Stenosis|Transcatheter Aortic Valve Replacement (TAVR)|Transcatheter Aortic Valve Implantation (TAVI)
Fundacin Biomedica Galicia Sur
 2022-01-21 Phase 4
NCT03869268 COMPLETED
Acute Coronary Syndrome
Sheffield Teaching Hospitals NHS Foundation Trust
 2019-04-24 PHASE4
NCT03775746 UNKNOWN
Acute Coronary Syndrome
East and North Hertfordshire NHS Trust
 2019-01-08 PHASE4
NCT05474053 COMPLETED
Cardiovascular Diseases; Acute Coronary Syndrome
Cairo University
 2021-11-13 PHASE3
NCT04945616 COMPLETED
Thrombosis
Jiangsu HengRui Medicine Co., Ltd.
 2021-07-13 PHASE1
NCT04069234 WITHDRAWN
Diabetes Mellitus; Microvascular Coronary Artery Disease
Region Skane
 2019-09-15 PHASE3
NCT04625764 TERMINATED
Acute Coronary Syndrome
CytoSorbents Europe GmbH
 2021-02-23
NCT03649711 COMPLETED
Chronic Kidney Diseases; Heart Attack; Stroke, Ischemic
University of Arkansas
 2018-11-01 PHASE3
NCT04122170 COMPLETED
Healthy
SFJ Pharmaceuticals, Inc.
 2019-09-24 PHASE2
NCT04570345 UNKNOWN
ST Elevation Myocardial Infarction
Dong-A University
 2021-01-01 PHASE4
NCT04634162 COMPLETED
Coronary Artery Disease
University of Florida
 2021-02-09 PHASE4
NCT04567290 UNKNOWN
Acute Coronary Syndrome
Centro Hospitalario La Concepcion
 2020-10-07 PHASE4
NCT03789916 RECRUITING
Coronary Artery Disease
Campus Bio-Medico University
 2019-01-02 PHASE3
NCT04078737 COMPLETED
Stroke; Transient Ischemic Attack
Beijing Tiantan Hospital
 2019-09-23 PHASE3
NCT04734353 UNKNOWN
Coronary Artery Disease
Gyeongsang National University Hospital
 2020-01-15 PHASE4
NCT03078465 WITHDRAWN
Coronary Artery Disease
Nanjing First Hospital, Nanjing Medical University
 2017-06-20 PHASE3
NCT04116931 UNKNOWN
Acute Coronary Syndrome (ACS)
The First Affiliated Hospital with Nanjing Medical University
 2020-06-22 PHASE4
NCT04131959 TERMINATED
Emergent Cardiothoracic Surgery; Bleeding; Drug Removal
CytoSorbents, Inc
 2019-10-29
NCT03273075 UNKNOWN
Cardiopulmonary Arrest With Successful Resuscitation; ACS - Acute Coronary Syndrome; Hypothermia, Induced
Medical University of Vienna
 2017-09 PHASE4
NCT02668562 COMPLETED
Acute Coronary Syndrome
Ottawa Heart Institute Research Corporation
 2016-02
NCT04338919 UNKNOWN
Acute Coronary Syndrome; Percutaneous Coronary Intervention
Fujian Medical University
 2020-04-14
NCT04331145 COMPLETED
Symptomatic Aortic Stenosis
Andres Iñiguez Romo
 2020-06-23 PHASE4
NCT05247385 COMPLETED
Coronary Artery Disease
University of Sao Paulo
 2017-03-20 PHASE4
NCT02018055 COMPLETED
Acute Myocardial Infarction
The Catholic University of Korea
 2014-02-14 PHASE4
NCT03620760 UNKNOWN
Unstable Angina Pectoris; Coronary Stent Implantation
Xiaofan Wu
 2018-08-07 PHASE4
NCT03708588 COMPLETED
Percutaneous Coronary Intervention
Wake Forest University Health Sciences
 2018-09-19 PHASE4
NCT04060914 UNKNOWN
Antiplatelet Therapy; Coronary Artery Disease; Percutaneous Coronary Intervention
Beijing Anzhen Hospital
 2019-08-30 PHASE4
NCT04001894 COMPLETED
Platelet Reactivity
First Affiliated Hospital of Harbin Medical University
 2019-07-02 PHASE4
NCT02302508 WITHDRAWN
Diabetes
Centre hospitalier de l'Université de Montréal (CHUM)
 2019-09-01 PHASE4
NCT02701140 COMPLETED
Myocardial Ischemia
Italo Porto
 2016-06 PHASE2; PHASE3
NCT01742117 COMPLETED
Coronary Artery Disease; Acute Coronary Syndrome; Stenosis
Mayo Clinic
 2013-05 PHASE4
NCT04941196 COMPLETED
Healthy Individuals
University of Karachi
 2020-10-16 PHASE1
NCT04023630 UNKNOWN
Atrial Fibrillation; Acute Coronary Syndromes
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2019-10-01 PHASE4
NCT03884530 COMPLETED
Acute Stroke; Ischemic Stroke
Kafrelsheikh University
 2019-05-01 PHASE3
NCT03822377 COMPLETED
ST Elevation Myocardial Infarction; NSTEMI - Non-ST Segment Elevation MI
Azienda Ospedaliero Universitaria di Sassari
 2019-06-27 PHASE3
NCT02913469 UNKNOWN
ST-segment Elevation Myocardial Infarction
General Hospital of Chinese Armed Police Forces
 2014-12-12 PHASE4
NCT03615924 TERMINATED
Sickle Cell Disease
AstraZeneca
 2018-09-26 PHASE3
NCT02053909 COMPLETED
Saphenous Vein Graft Disease
Boca Raton Regional Hospital
 2014-09 PHASE4
NCT02352402 UNKNOWN
Coronary Artery Disease; Stable Angina; Acute Coronary Syndrome
J.M. ten Berg
 2015-03 PHASE3
NCT03989557 COMPLETED
Unruptured Intracranial Aneurysm; Stents; Antiplatelet Drugs
Beijing Neurosurgical Institute
 2019-07-01 PHASE4
NCT02675205 COMPLETED
Cerebral Aneurysm
Fondation Ophtalmologique Adolphe de Rothschild
 2015-12 PHASE3
NCT02285751 UNKNOWN
Critical Illness
Medical University of Vienna
 2012-11 PHASE2
NCT02617290 COMPLETED
Coronary Artery Disease; Myocardial Ischemia; Myocardial Infarction; Stent Thrombosis; Cardiovascular Diseases
Assistance Publique - Hôpitaux de Paris
 2017-01-09 PHASE3
NCT02230527 TERMINATED
Peripheral Arterial Disease
The Cleveland Clinic
 2014-10 PHASE2; PHASE3
NCT04206176 COMPLETED
Platelet Dysfunction Due to Drugs
The University of The West Indies
 2019-10-01 PHASE1; PHASE2
NCT02989558 COMPLETED
Aortic Valve Stenosis
University of Athens
 2016-12 PHASE3
NCT02944123 COMPLETED
Acute Coronary Syndrome
Dong-A University
 2016-09 PHASE3
NCT03039205 COMPLETED
Platelet Aggregation; Adenosine; Coronary Artery Disease; Kidney Dysfunction; Antiplatelet Therapy
University of Sao Paulo
 2017-11-07 PHASE2
NCT03381755 UNKNOWN
Acute Coronary Syndrome
First Affiliated Hospital of Harbin Medical University
 2018-01-01 PHASE4
NCT03354429 COMPLETED
Acute Ischaemic Stroke; Transient Ischaemic Attack
AstraZeneca
 2018-01-22 PHASE3
NCT02341729 COMPLETED
Acute Coronary Syndrome
University Hospital, Ghent
 2015-03 PHASE4
NCT04369534 COMPLETED
Acute Coronary Syndrome; STEMI; NSTEMI - Non-ST Segment Elevation MI; PLATELET AGGREGATION; INDIVIDUALIZED THERAPY
University of Zagreb
 2015-12-01 PHASE4
NCT02539160 COMPLETED
Coronary Artery Disease; Diabetes Mellitus
University of Florida
 2016-02 PHASE4
NCT03400267 COMPLETED
STEMI; STEMI - ST Elevation Myocardial Infarction
A.H. Tavenier
 2018-02-16 PHASE4
NCT03928353 COMPLETED
Healthy
SFJ Pharmaceuticals, Inc.
 2019-04-16 PHASE2
NCT04962451 COMPLETED
Cerebrovascular Accident; Cerebrovascular Accident, Acute
Peking University Third Hospital
 2017-09-01 PHASE4
NCT03062462 UNKNOWN
Coronary Artery Disease; Clopidogrel, Poor Metabolism of
First Affiliated Hospital of Harbin Medical University
 2017-02-10 PHASE2; PHASE3
NCT02270242 COMPLETED
Cardiovascular Disease; Interventional Cardiology
Icahn School of Medicine at Mount Sinai
 2015-07 PHASE4
NCT01944800 COMPLETED
Acute Coronary Syndrome (ACS)
Deutsches Herzzentrum Muenchen
 2013-09-15 PHASE4
NCT03437044 COMPLETED
Diabetes Mellitus, Type 2; Coronary Artery Disease
University of Florida
 2018-03-14 PHASE4
NCT02866175 COMPLETED
Atrial Fibrillation
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
 2017-02-24 PHASE3
NCT03182855 UNKNOWN
Acute Coronary Syndrome; Myocardial Infarction; STEMI - ST Elevation Myocardial Infarction
University of Aarhus
 2018-09-01 PHASE4
NCT02335099 COMPLETED
End Stage Renal Disease; Vascular Access Patency
University of Virginia
 2014-12 PHASE1; PHASE2
NCT02211066 COMPLETED
Patients Who Are Scheduled to Undergo a PCI (Percutaneous Coronary Intervention) for CTO (Chronic Total Occlusion)
Hospital Clinic of Barcelona
 2014-10 PHASE4
NCT03430661 COMPLETED
Healthy
Viatris Innovation GmbH
 2018-01-24 PHASE1
NCT03492931 COMPLETED
Sickle Cell Disease
AstraZeneca
 2018-03-28 PHASE1
NCT03614832 UNKNOWN
Platelet Reactivity
First Affiliated Hospital of Harbin Medical University
 2018-05-01 PHASE4
NCT02545933 COMPLETED
Myocardial Infarction
University of Florida
 2016-02 PHASE4
NCT03150667 UNKNOWN
Chronic Kidney Diseases; Acute Coronary Syndrome
North Texas Veterans Healthcare System
 2017-04-10 PHASE4
NCT02065479 COMPLETED
Coronary Artery Disease
University of Florida
 2014-03 PHASE4
NCT02874092 COMPLETED
Rheumatoid Arthritis
NYU Langone Health
 2016-11-15 PHASE4
NCT05643586 COMPLETED
Coronary Artery Disease
Germano Di Sciascio
 2017-12-01 PHASE4
NCT02762864 UNKNOWN
Peripheral Artery Disease
Chang Gung Memorial Hospital
 2016-05
NCT03489863 COMPLETED
Coronary Artery Disease
University of Florida
 2018-05-30 PHASE4
NCT03679091 COMPLETED
Platelet Reactivity
First Affiliated Hospital of Harbin Medical University
 2018-08-29 PHASE4
NCT02206815 COMPLETED
Atrial Fibrillation; Coronary Artery Disease
Genshan Ma
 2014-09-19 PHASE4
NCT02429271 COMPLETED
Myocardial Infarction; ST Segment Elevation Myocardial Infarction (STEMI)
Hellenic Cardiovascular Research Society
 2015-08 PHASE3
NCT03387826 COMPLETED
Myocardial Infarction; Diabetes Mellitus; Coronary Artery Disease; Renal Disease
Attikon Hospital
 2018-01-11 PHASE4
NCT01991795 COMPLETED
Diabetes Mellitus, Type 2
AstraZeneca
 2014-02-10 PHASE3
NCT02486367 COMPLETED
Aortic Stenosis; Inflammation; Thrombosis
University Hospitals Cleveland Medical Center
 2015-06 PHASE4
NCT02931045 COMPLETED
Myocardial Infarction
Medical University of Warsaw
 2017-12-30 PHASE4
NCT03881943 COMPLETED
Acute Coronary Syndrome
The University of Hong Kong
 2017-01 PHASE4
NCT03247738 COMPLETED
ST Segment Elevation Myocardial Infarction; Percutaneous Coronary Intervention
University of Florida
 2017-11-20 PHASE4
NCT03381742 COMPLETED
Coronary Artery Disease
First Affiliated Hospital of Harbin Medical University
 2017-12-13 PHASE2; PHASE3
NCT02939248 COMPLETED
Unstable Angina Pectoris
Collegium Medicum w Bydgoszczy
 2016-10 PHASE4
NCT02748330 COMPLETED
Coronary Artery Disease; Diabetes Mellitus, Type 2
Peking Union Medical College Hospital
 2016-06 PHASE4
NCT03145194 UNKNOWN
ST Elevation Myocardial Infarction
Papworth Hospital NHS Foundation Trust
 2017-01-30 PHASE2
NCT02094963 COMPLETED
Acute Coronary Syndrome; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Angina Pectoris
Seung-Jung Park
 2014-07-05 PHASE4
NCT02317198 COMPLETED
Non-ST-elevation Acute Coronary Syndrome; Unstable Angina; Non-ST-elevation Myocardial Infarction
St. Antonius Hospital
 2013-06 PHASE4
NCT03435133 COMPLETED
ST Elevation Myocardial Infarction
AORTICA Group
 2015-11-23
NCT02733341 COMPLETED
Acute Coronary Syndrome (ACS); High On-treatment Platelet Reactivity (HTPR); Microvascular Obstruction (MVO); ST-segment Elevation Myocardial Infarction (STEMI); Thrombolysis in Myocardial Infarction (TIMI); Unstable Angina (UA)
The Royal Wolverhampton Hospitals NHS Trust
 2016-07-21 PHASE4
NCT02627950 COMPLETED
Acute Myocardial Infarction
University of Luebeck
 2015-12 PHASE4
NCT03224923 TERMINATED
Stable Coronary Syndrome; Percutaneous Coronary Intervention; Antiplatelet Therapy; Ticagrelor
Ottawa Heart Institute Research Corporation
 2017-08-18 PHASE4
NCT03492385 COMPLETED
Healthy
SFJ Pharmaceuticals, Inc.
 2018-04-03 PHASE1
NCT02767401 COMPLETED
Hibernation, Myocardial; Complete Occlusion of Coronary Artery
The First Affiliated Hospital of Dalian Medical University
 2015-09-15 PHASE4
NCT02071212 COMPLETED
Coronary Artery Disease
Hellenic Cardiovascular Research Society
 2014-02 PHASE2
NCT02327624 COMPLETED
Coronary Artery Disease
Sheffield Teaching Hospitals NHS Foundation Trust
 2015-06 PHASE4
NCT02817789 TERMINATED
Aortic Valve Stenosis
University Hospital, Bordeaux
 2016-05-09 PHASE3
NCT02505399 COMPLETED
Atherosclerosis
University Hospital, Toulouse
 2015-11 PHASE4
NCT01755520 TERMINATED
Coronary Artery Disease; Stable Angina; Acute Coronary Syndrome
Deutsches Herzzentrum Muenchen
 2013-04-24 PHASE3
NCT02325466 COMPLETED
Peripheral Artery Disease; Type 2 Diabetes
Icahn School of Medicine at Mount Sinai
 2015-04 PHASE3
NCT02428725 COMPLETED
Acute Coronary Syndrome
Assistance Publique Hopitaux De Marseille
 2015-04
NCT02428374 UNKNOWN
Myocardial Fibrosis
Federal University of São Paulo
 2015-05 PHASE4
NCT03441412 COMPLETED
Healthy Volunteers
Vastra Gotaland Region
 2018-02-28 PHASE1
NCT03251859 COMPLETED
Myocardial Infarction
Collegium Medicum w Bydgoszczy
 2017-08-11 PHASE3
NCT02531165 COMPLETED
Acute Myocardial Infarction
Centre Hospitalier Universitaire Vaudois
 2015-09
NCT03104062 COMPLETED
Coronary Microvascular Disease; Ticagrelor; Thrombolysis; Microbubble Contrasted Echocardiography
University of Sao Paulo General Hospital
 2016-10-01
NCT02925923 COMPLETED
Acute Coronary Syndrome; Angina, Unstable
University of Alabama at Birmingham
 2016-11-01 PHASE2
NCT03577652 COMPLETED
Coronary Artery Disease; Ticagrelor
Shenyang Northern Hospital
 2017-07-10
NCT02792712 UNKNOWN
Acute Coronary Syndrome
Taipei Veterans General Hospital, Taiwan
 2016-01 PHASE4
NCT01739556 TERMINATED
Acute ST-elevation Myocardial Infarction
Clinical Centre of Serbia
 2015-06 PHASE3
NCT02626169 WITHDRAWN
Atherosclerosis
Baylor College of Medicine
 2015-12 PHASE4
NCT04174261 COMPLETED
Periprocedural Myocardial Infarction
Hellenic Society of Interventional Cardiology
 2017-01-29 PHASE4
NCT03119012 TERMINATED
Coronary Artery Disease; Stents; Atherosclerosis
Samsung Medical Center
 2017-04-19 PHASE4
NCT02298088 COMPLETED
Acute ST Segment Elevation Myocardial Infarction; Thrombolysis in Myocardial Infarction Flow
Hospital do Coracao
 2015-08 PHASE3
NCT03005704 UNKNOWN
Ticagrelor; Aspirin; Platelet Dysfunction Due to Drugs; Transfusion
Hamilton Health Sciences Corporation
 2017-01
NCT01743937 TERMINATED
Ischemic Preconditioning
University of Texas Southwestern Medical Center
 2013-01 PHASE4
NCT02942550 COMPLETED
STEMI; Morphine; Ticagrelor; Methylnaltrexone
Karolinska University Hospital
 2016-11 PHASE4
NCT02939235 COMPLETED
Unstable Angina Pectoris
Collegium Medicum w Bydgoszczy
 2016-07 PHASE4
NCT03016611 UNKNOWN
Acute Coronary Syndrome; STEMI
Sheba Medical Center
 2017-02 PHASE4
NCT02639143 COMPLETED
Inflammation; Thrombosis
First Affiliated Hospital of Harbin Medical University
 2015-12 PHASE4
NCT02943369 COMPLETED
STEMI
Attikon Hospital
 2017-07-28 PHASE4
NCT01701453 UNKNOWN
Acute Coronary Syndrome
Samsung Medical Center
 2012-08
NCT03487406 COMPLETED
Chronic Obstructive Pulmonary Disease (COPD)
Newcastle-upon-Tyne Hospitals NHS Trust
 2015-09 PHASE2
NCT03027934 WITHDRAWN
Diabetes Mellitus
CirQuest Labs, LLC
 2017-08-28 PHASE4
NCT02889549 UNKNOWN
Coronary Artery Disease
First Affiliated Hospital of Harbin Medical University
 2016-08 PHASE2; PHASE3
NCT02287909 COMPLETED
Coronary Artery Disease
University of Florida
 2014-12 PHASE4
NCT02518464 COMPLETED
Migraine; Headache; Migraine Headache
Columbia University
 2015-10 PHASE4
NCT02422888 UNKNOWN
Myocardial Infarction
Amsterdam UMC, location VUmc
 2015-05 PHASE4
NCT02627521 UNKNOWN
Coronary Artery Disease
Unity Health Toronto
 2015-07 PHASE4
NCT02507323 WITHDRAWN
Cardiovascular Disease
Yochai Birnbaum
 2016-02 PHASE2
NCT03126695 COMPLETED
Sickle Cell Disease
AstraZeneca
 2017-05-12 PHASE1
NCT02164864 COMPLETED
Atrial Fibrillation; Percutaneous Coronary Intervention
Boehringer Ingelheim
 2014-07-22 PHASE3
NCT02224534 UNKNOWN
ST Elevation Myocardial Infarction
Gyeongsang National University Hospital
 2014-10 PHASE4
NCT02663713 COMPLETED
Myocardial Infarction; Diabetes Mellitus; Renal Disease; Coronary Artery Disease
University of Patras
 2017-01 PHASE4
NCT02110303 COMPLETED
Coronary Artery Disease
University of Edinburgh
 2015-03 PHASE2; PHASE3
NCT02683707 COMPLETED
Coronary Artery Disease
Johns Hopkins University
 2016-03 PHASE4
NCT02224066 COMPLETED
Severe Aortic Valve Stenosis; Transcatheter Aortic Valve Implantation; Transcatheter Aortic Valve Replacement
Hospital de Meixoeiro
 2016-01 PHASE4
NCT02140801 COMPLETED
Thrombosis
Nanjing First Hospital, Nanjing Medical University
 2014-05-01 PHASE4
NCT02506140 COMPLETED
Stroke; Ischemic Attack, Transient
Beijing Tiantan Hospital
 2015-08 PHASE2; PHASE3
NCT02698618 UNKNOWN
Diabetes Mellitus, Type 2
Fundacion Investigacion Interhospitalaria Cardiovascular
 2016-03 PHASE4
NCT02513004 UNKNOWN
Coronary Disease
Yongjian Wu
 2015-06 PHASE4
NCT02214121 COMPLETED
Investigation of Platelet Aggregation in Paediatric Patients With Sickle Cell Disease
AstraZeneca
 2014-09-11 PHASE2
NCT02319941 COMPLETED
Acute Coronary Syndrome
Seung-Jung Park
 2015-05-20 PHASE2
NCT02587260 COMPLETED
Cardiovascular Diseases
Erasmus Medical Center
 2015-12-17 PHASE4
NCT02406248 COMPLETED
Non ST-elevation Myocardial Infarction
AstraZeneca
 2015-04-23 PHASE4
NCT02910778 COMPLETED
Ischemia
Medical University of Vienna
 2016-10 PHASE4
NCT02407314 TERMINATED
Peripheral Arterial Disease
Arkansas Heart Hospital
 2015-06 PHASE4
NCT02201771 COMPLETED
Coronary Artery Bypass; Antiplatelet Agents
Ruijin Hospital
 2014-07 PHASE4
NCT02725099 COMPLETED
Acute Coronary Syndromes; ST Elevation Myocardial Infarction
Sheba Medical Center
 2016-05 PHASE4
NCT01690884 COMPLETED
Coronary Artery Disease
Vanderbilt University
 2012-08 PHASE1
NCT01955200 COMPLETED
Coronary Artery Disease
The First Affiliated Hospital with Nanjing Medical University
 2013-10-05 PHASE4
NCT05278637 COMPLETED
Platelet Aggregation Inhibitors; Aspirin; Ticagrelor; RNA
Duke University
 2013-11-01 EARLY_PHASE1
NCT02457130 UNKNOWN
Coronary Artery Disease; Diabetes Mellitus. Type 2
Spanish Society of Cardiology
 2015-04 PHASE4
NCT01738100 UNKNOWN
ST-Segment Elevation Myocardial Infarction
Hyeon-Cheol Gwon
 2012-09 PHASE2
NCT02415803 UNKNOWN
Non ST Segment Elevation Acute Coronary Syndrome
First Affiliated Hospital of Harbin Medical University
 2014-12 PHASE3
NCT02798874 UNKNOWN
Cardiovascular Diseases
Chinese PLA General Hospital
 2016-05
NCT02618733 COMPLETED
Acute Coronary Syndrome
Dong-A University
 2014-12
NCT02379676 UNKNOWN
Endothelial Dysfunction; Vascular Inflammation
Kiyuk Chang
 2015-01 PHASE4
NCT02091921 COMPLETED
Critical Limb Ischemia
University of Southern California
 2014-02-16 PHASE1; PHASE2
NCT02482298 COMPLETED
Sickle Cell Disease
AstraZeneca
 2015-07-09 PHASE2
NCT02284048 UNKNOWN
Microvascular Angina
Second Xiangya Hospital of Central South University
 2014-11 PHASE4
NCT02383771 COMPLETED
Coronary Artery Disease
The First Affiliated Hospital with Nanjing Medical University
 2015-03 PHASE4
NCT02376283 COMPLETED
Heart Attack
The Royal Wolverhampton Hospitals NHS Trust
 2015-03-09 PHASE4
NCT02293395 COMPLETED
Acute Coronary Syndrome
Janssen Research & Development, LLC
 2015-04-20 PHASE2
NCT02330640 COMPLETED
Antiplatelet Therapy of Coronary Artery Bypass
Chinese Academy of Medical Sciences, Fuwai Hospital
 2016-01 PHASE4
NCT02044146 COMPLETED
Acute Coronary Syndrome; Percutaneous Coronary Intervention
Ottawa Heart Institute Research Corporation
 2014-09 PHASE2; PHASE3
NCT01930591 COMPLETED
Acute Myocardial Infarction
Unity Health Toronto
 2014-05 PHASE3
NCT02037412 TERMINATED
Acute Coronary Syndrome; Acute Myocardial Infarction; Unstable Angina (Intermediate Coronary Syndrome)
Yonsei University
 2014-01 PHASE4
NCT01732822 COMPLETED
Peripheral Artery Disease
AstraZeneca
 2012-12-04 PHASE3
NCT02233790 UNKNOWN
Myocardial Infarction; No-Reflow Phenomenon
First Hospital of China Medical University
 2014-12 PHASE4
NCT02244710 COMPLETED
Acute Coronary Syndrome (ACS)
Fundación Investigación Sanitaria en León
 2015-03
NCT02612116 COMPLETED
Unstable Angina Pectoris
Collegium Medicum w Bydgoszczy
 2015-09 PHASE4
NCT02658838 UNKNOWN
LOVASTATIN/TICAGRELOR [VA Drug Interaction]
Beijing Anzhen Hospital
 2015-04 PHASE4
NCT02201667 UNKNOWN
Acute Coronary Syndrome
RenJi Hospital
 2014-08 PHASE4
NCT02487732 COMPLETED
Acute Coronary Syndrome
Korea University Anam Hospital
 2015-07 PHASE4
NCT01830543 COMPLETED
Atrial Fibrillation; Percutaneous Coronary Intervention
Janssen Scientific Affairs, LLC
 2013-05-10 PHASE3
NCT02070653 COMPLETED
Abdominal Aortic Aneurysm
Uppsala University
 2014-03 PHASE2
NCT02169596 COMPLETED
Acute Coronary Syndome
Hull University Teaching Hospitals NHS Trust
 2015-06 PHASE4
NCT01700322 COMPLETED
Coronary Artery Disease
Johannes Gutenberg University Mainz
 2012-08 PHASE4
NCT02201394 COMPLETED
Coronary Artery Disease
Icahn School of Medicine at Mount Sinai
 2014-07 PHASE4
NCT02224274 COMPLETED
Cardiac Arrest; Postresuscitation Syndrome; Myocardial Infarction (ST-Elevation Myocardial Infarction and Non-ST-Elevation Myocardial Infarction)
University Medical Centre Ljubljana
 2014-08 PHASE4
NCT02519608 COMPLETED
Coronary Artery Disease; Chronic Obstructive Pulmonary Disease
University Hospital of Ferrara
 2015-09 PHASE2
NCT02291419 TERMINATED
Myocardial Injury
The Cleveland Clinic
 2015-07 PHASE4
NCT01883869 COMPLETED
Pneumonia; Community Acquired Pneumonia; Hospital Acquired Pneumonia; Acute Lung Injury
University of Kentucky
 2013-06 PHASE1
NCT02227368 TERMINATED
Peripheral Artery Disease (PAD)
AstraZeneca
 2014-10-20 PHASE2
NCT01823510 COMPLETED
Type-2 Diabetes Mellitus; Coronary Artery Disease
Juan J Badimon
 2013-07 PHASE4
NCT02022748 COMPLETED
Kidney Failure, Chronic
AstraZeneca
 2013-12-29 PHASE1
NCT02123004 UNKNOWN
ST-Segment Elevation Myocardial Infarction
Jinan Central Hospital
 2014-04 PHASE4
NCT02808767 COMPLETED
Myocardial Infarction; Angioplasty, Balloon, Coronary; Platelet Aggregation Inhibitors
Faculty Hospital Kralovske Vinohrady
 2013-01 PHASE4
NCT02403830 COMPLETED
Coronary Artery Disease
University of Florida
 2015-08 PHASE4
NCT02282332 COMPLETED
Coronary Artery Disease
Medstar Health Research Institute
 2014-06 PHASE4
NCT02578537 UNKNOWN
Non ST Segment Elevation Acute Coronary Syndrome; Chronic Kidney Disease
Shenyang Northern Hospital
 2015-10 PHASE4
NCT02041650 COMPLETED
Acute Coronary Syndrome
Yu Bo
 2014-08 PHASE4
NCT01994720 COMPLETED
Acute Ischaemic Stroke; Transient Ischaemic Attack
AstraZeneca
 2014-01-07 PHASE3
NCT02048228 UNKNOWN
CLOPIDOGREL, POOR METABOLISM of (Disorder)
Chinese PLA General Hospital
 2014-10 PHASE2; PHASE3
NCT02580149 COMPLETED
Ischemia
Michael Wolzt, Prof. MD
 2015-10 PHASE4
NCT02402400 COMPLETED
Acute Coronary Syndromes; Non ST Elevation Myocardial Infarction
Sheba Medical Center
 2015-07 PHASE4
NCT01805596 COMPLETED
Coronary Artery Disease; Endothelial Function
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2013-04 PHASE3
NCT02121288 WITHDRAWN
Peripheral Artery Disease; Vascular Disease; Arterial Occlusion Disease; Intermittent Claudication; Ankle Brachial Index (0.9 or Less)
AstraZeneca
 2014-12 PHASE4
NCT02469740 COMPLETED
Myocardial Ischemia; Coronary Artery Disease; Endothelial Dysfunction
University Hospital of Limerick
 2015-07 PHASE4
NCT01823185 UNKNOWN
Coronary Artery Disease; Myocardial Infarction; Heart Disease; Vascular Disease; Angina Pectoris; Cardiovascular Disease; Ischemia; Infarction; Embolism; Thrombosis; Chest Pain
Imam Abdulrahman Bin Faisal University
 2013-03 PHASE4
NCT01957540 COMPLETED
Coronary Artery Disease; Endothelial Function
University of Patras
 2014-06 PHASE4
NCT02612480 COMPLETED
Endotoxemia
Radboud University Medical Center
 2015-10
NCT02071966 TERMINATED
Non ST Segment Elevation Acute Coronary Syndrome
Catholic University of the Sacred Heart
 2012-11 PHASE4
NCT01812330 UNKNOWN
Acute Coronary Syndrome
General Hospital of Chinese Armed Police Forces
 2013-01 PHASE3
NCT02459288 UNKNOWN
Acute Coronary Syndrome; Chronic Kidney Disease; End-Stage Renal Disease
Ping-Yen Liu
 2014-01 PHASE4
NCT01998399 TERMINATED
Community Acquired Pneumonia, Severe
Gordon Bernard
 2014-08 PHASE2
NCT01962428 COMPLETED
Non ST Segment Elevation Acute Coronary Syndrome
General Hospital of Chinese Armed Police Forces
 2014-06 PHASE4
NCT01919723 COMPLETED
Acute Coronary Syndrome
University of Alabama at Birmingham
 2014-02 PHASE2
NCT02311088 TERMINATED
Dyspnea
Uppsala University
 2014-12 PHASE2
NCT01869309 UNKNOWN
Coronary Artery Disease
LifeBridge Health
 2014-01 PHASE4
NCT01813435 COMPLETED
Coronary Artery Disease (CAD)
ECRI bv
 2013-07-01 PHASE3
NCT03092076 COMPLETED
Healthy
Guangdong Provincial People's Hospital
 2015-05-20 PHASE1
NCT02081443 COMPLETED
Coronary Artery Disease
University of Florida
 2014-04
NCT02261922 UNKNOWN
Antiplatelet Agents; Endothelial Function; Pleotropic Effects
Hotel Dieu de France Hospital
 2014-10 PHASE4
NCT02514642 UNKNOWN
Coronary Artery Disease
First Affiliated Hospital of Harbin Medical University
 2015-07 PHASE4
NCT02016170 COMPLETED
Coronary Artery Disease; Acute Coronary Syndrome
University of Florida
 2014-03
NCT01870921 COMPLETED
Acute Coronary Syndrome
AstraZeneca
 2013-06-26 PHASE4
NCT02699008 COMPLETED
Acute Coronary Syndrome
Wuhan Asia Heart Hospital
 2014-01
NCT02394145 UNKNOWN
Chronic Kidney Disease
Kyunghee University Medical Center
 2009-09 PHASE3
NCT01994941 COMPLETED
Acute Coronary Syndrome
The University of Hong Kong
 2013-08 PHASE4
NCT02436577 COMPLETED
Bioequivalence; Healthy Japanese Subjects; Pharmacokinetics
AstraZeneca
 2015-06 PHASE1
NCT01905566 COMPLETED
Plaque, Atherosclerotic
CHEOL WHAN LEE, M.D., Ph.D
 2013-09 PHASE4
NCT02400333 COMPLETED
Bioavailability; Healthy Subjects
AstraZeneca
 2015-06 PHASE1
NCT01852214 COMPLETED
Diabetes Mellitus; Coronary Artery Disease
University of Florida
 2013-02
NCT01531114 COMPLETED
ST-Elevation Myocardial Infarction
Gennaro Sardella
 2013-05 PHASE3
NCT02217878 COMPLETED
ST-segment Elevation Myocardial Infarction; Non-ST-segment Elevation Myocardial Infarction; VA Drug Interactions
Collegium Medicum w Bydgoszczy
 2014-08 PHASE4
NCT02406911 UNKNOWN
Chronic Kidney Disease
Kyunghee University Medical Center
 2015-02 PHASE3
NCT02742987 COMPLETED
Coronary Artery Disease; Diabetes Mellitus
Campus Bio-Medico University
 2014-03 PHASE4
NCT02219412 COMPLETED
Coronary Heart Disease
Yong Huo
 2014-08 PHASE4
NCT02048085 WITHDRAWN
Acute ST Segment Elevation Myocardial Infarction; Acute Coronary Syndrome
Medical Center of South Arkansas
 2014-01-02 PHASE4
NCT02052635 TERMINATED
Non-ST Elevation Acute Coronary Syndrome
AstraZeneca
 2014-09 PHASE4
NCT02075125 TERMINATED
ST-Segment Elevation Myocardial Infarction
Dong-A University
 2014-01 PHASE3
NCT02435563 COMPLETED
Healthy
University Hospital, Geneva
 2014-08 PHASE2
NCT01373411 COMPLETED
Coronary Artery Disease
Cardiology Research UBC
 2011-09 PHASE4
NCT01894789 COMPLETED
Coronary Artery Disease
Ottawa Heart Institute Research Corporation
 2013-03 PHASE2; PHASE3
NCT02054663 COMPLETED
Acute Coronary Syndrome
Ottawa Heart Institute Research Corporation
 2013-12 PHASE4
NCT01916902 WITHDRAWN
Acute Coronary Syndrome; Coronary Artery Disease
Massachusetts General Hospital
 2014-02 PHASE4
NCT02046486 COMPLETED
ST Elevation Myocardial Infarction
University of Patras
 2014-01 PHASE4
NCT02012140 UNKNOWN
Cardiovascular Disease; Stable Angina; Myocardial Infarction; Coronary Artery Disease
LifeBridge Health
 2014-01 PHASE4
NCT02032290 UNKNOWN
Acute Coronary Syndrome:; Non ST Elevation Myocardial Infarction; ST Elevation Myocardial Infarction; Unstable Angina
Azienda Policlinico Umberto I
 2014-02 PHASE4
NCT01225562 COMPLETED
Myocardial Infarction; Cardiovascular Death; Atherothrombosis; Stroke
AstraZeneca
 2010-10 PHASE3
NCT01950416 COMPLETED
ST Elevation Myocardial Infarction; Fibrinolysis; P2Y12 Inhibitor
University of Patras
 2013-03 PHASE4
NCT02032303 UNKNOWN
Acute Coronary Syndrome; Non ST Elevation Myocardial Infarction; ST Elevation Myocardial Infarction; Unstable Angina
Azienda Policlinico Umberto I
 2014-02 PHASE4
NCT02064985 COMPLETED
Stable Coronary Heart Disease (CHD)
AstraZeneca
 2014-02 PHASE4
NCT02080858 COMPLETED
Atrial Fibrillation; Acute Coronary Syndrome
Medical University of Vienna
 2014-05 PHASE1
NCT02026219 COMPLETED
Non-ST Segment Elevation Myocardial Infarction; ST Segment Elevation Myocardial Infarction
Inha University Hospital
 2013-10 PHASE4
NCT02108808 COMPLETED
Fractional Flow Reserve
University of Patras
 2014-04 PHASE4
NCT02215993 COMPLETED
Acute Coronary Syndrome; Platelet Function
Federal University of São Paulo
 2013-07 PHASE4
NCT01643031 UNKNOWN
Diabetes Mellitus; Coronary Disease
Rabin Medical Center
 2012-08 PHASE4
NCT01852175 COMPLETED
Coronary Artery Disease
University of Florida
 2012-01
NCT01898442 COMPLETED
Coronary Artery Disease
University of Florida
 2013-09 PHASE2
NCT01603082 COMPLETED
Acute Coronary Syndrome
AstraZeneca
 2012-07 PHASE4
NCT02101437 COMPLETED
PRU; miRNA
Taipei City Hospital
 2014-01
NCT01731041 COMPLETED
Coronary Artery Disease
University of Florida
 2013-01
NCT01826175 WITHDRAWN
Acute Coronary Syndrome; Coronary Artery Disease
Massachusetts General Hospital
 2013-05 PHASE4
NCT01744288 COMPLETED
Inhibition on Platelet Aggregation
AstraZeneca
 2012-12 PHASE1
NCT02086903 COMPLETED
Pharmacodynamics
Dong-A University
 2014-02 PHASE3
NCT01456364 UNKNOWN
Coronary Heart Disease
Deutsches Herzzentrum Muenchen
 2011-09 PHASE4
NCT01706510 COMPLETED
Coronary Artery Disease
Rapid City Regional Hospital, Inc
 2012-12 PHASE4
NCT01864005 COMPLETED
Non-ST or ST Elevation Acute Coronary Syndromes
AstraZeneca
 2013-05 PHASE4
NCT01992523 COMPLETED
Acute Coronary Syndrome; Adverse Reaction to Antiplatelet Agent
David Antoniucci
 2013-11 PHASE3
NCT01961856 COMPLETED
Platelet Reactivity
University of Patras
 2013-09 PHASE3
NCT01626534 COMPLETED
Acute Coronary Syndrome
Assistance Publique Hopitaux De Marseille
 2012-03 PHASE3
NCT01846559 COMPLETED
Healthy
Sheffield Teaching Hospitals NHS Foundation Trust
 2013-04 PHASE4
NCT02120092 COMPLETED
Acute Coronary Syndrome
Medical University of Vienna
 2010-10 PHASE2
NCT01543932 COMPLETED
Coronary Artery Disease
University of Roma La Sapienza
 2012-07 PHASE3
NCT01996735 COMPLETED
Healthy
Radboud University Medical Center
 2013-04 PHASE4
NCT01347580 COMPLETED
Myocardial Infarction; Segment Elevation Myocardial Infarction (STEMI)
AstraZeneca
 2011-09 PHASE4
NCT01523392 COMPLETED
Stable Coronary Artery Disease
AstraZeneca
 2012-03 PHASE4
NCT01887626 COMPLETED
Bioavailability Heathy Volunteers
AstraZeneca
 2013-07 PHASE1
NCT02163954 COMPLETED
Chronic Kidney Disease
Kyunghee University Medical Center
 2013-01 PHASE3
NCT01660373 UNKNOWN
Non-ST Segment Elevation Acute Coronary Syndrome
Pusan National University Yangsan Hospital
 2012-08 PHASE3
NCT01876797 COMPLETED
Healthy
Asan Medical Center
 2013-07 PHASE1
NCT01734772 COMPLETED
Healthy
Boehringer Ingelheim
 2012-11 PHASE1
NCT01523366 COMPLETED
Stable Coronary Artery Disease
AstraZeneca
 2012-04 PHASE4
NCT01812200 COMPLETED
Atrial Fibrillation; Acute Coronary Syndrome
Medical University of Vienna
 2012-10 PHASE4
NCT01757262 WITHDRAWN
Coronary Heart Disease
AstraZeneca
 2013-01 PHASE3
NCT01805570 COMPLETED
Myocardial Infarction
David Antoniucci
 2012-11 PHASE4
NCT01642238 COMPLETED
Acute Coronary Syndrome
Juan J Badimon
 2012-07 PHASE4
NCT01587651 COMPLETED
Coronary Artery Disease
Daiichi Sankyo
 2012-03 PHASE4
NCT01766466 COMPLETED
Coronary Artery Disease
The Medicines Company
 2013-01 PHASE2
NCT01575795 COMPLETED
ST-elevation Myocardial Infarction
University of Patras
 2012-04 PHASE4
NCT01795820 COMPLETED
Acute Coronary Syndrome
University Magna Graecia
 2012-11
NCT01515345 COMPLETED
Platelet Inhibition; Coronary Stent Implantation
Kaiser Franz Josef Hospital
 2011-07 PHASE3
NCT01526577 COMPLETED
Acute Coronary Syndrome
LG Life Sciences
 2012-03 PHASE1
NCT01642966 COMPLETED
Acute Coronary Syndrome
University of Patras
 2012-09 PHASE4
NCT01642940 COMPLETED
Coronary Artery Disease; Acute Coronary Syndrome
University of Patras
 2012-06 PHASE4
NCT01294462 COMPLETED
Acute Coronary Syndrome; Percutaneous Coronary Intervention
AstraZeneca
 2011-02 PHASE3
NCT01504906 COMPLETED
Healthy
AstraZeneca
 2012-01 PHASE1
NCT01510171 COMPLETED
ST-segment Elevation Myocardial Infarction
Careggi Hospital
 2012-01 PHASE4
NCT01595854 COMPLETED
Healthy
Boehringer Ingelheim
 2012-05 PHASE1
NCT01463163 COMPLETED
Platelet Reactivity
University of Patras
 2011-10 PHASE4
NCT01350921 COMPLETED
Drug Drug Interaction
AstraZeneca
 2011-05 PHASE1
NCT01511471 COMPLETED
Platelet Reactivity
University of Patras
 2012-01 PHASE3
NCT01360437 COMPLETED
Coronary Artery Disease; Acute Coronary Syndrome
University of Patras
 2011-05 PHASE3
NCT01226602 COMPLETED
Blood Flow Speed; Coronary Flow Velocity
AstraZeneca
 2010-12 PHASE1
NCT01118325 COMPLETED
Stable Coronary Artery Disease
AstraZeneca
 2010-04 PHASE2
NCT00528411 COMPLETED
Coronary Artery Disease
AstraZeneca
 2007-10 PHASE2
NCT00391872 COMPLETED
Acute Coronary Syndrome
AstraZeneca
 2006-10 PHASE3
NCT00642811 COMPLETED
Stable Coronary Artery Disease
AstraZeneca
 2008-05 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-03-10)

Check the Ticagrelor product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Ticagrelor is a reversibly binding oral P2Y12 receptor antagonist that selectively targets adenosine diphosphate receptors on the platelet surface, thereby inhibiting downstream receptor-mediated intracellular signaling and activation of the glycoprotein IIb/IIIa complex. This inhibition prevents agonist-induced platelet aggregation, suppressing intravascular thrombus formation and demonstrating therapeutic relevance in clinical settings such as acute coronary syndrome and acute ischaemic stroke.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.