CAS No. 145821-59-6

Batch: Purity:99.78
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Tiagabine hydrochloride Chemical Structure
Chemical Structure
Check the Tiagabine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid;hydrochloride
CAS Number 145821-59-6
Molecular Formula

C20H25NO2S2.HCl
Molecular Weight (MW) 412.01
SMILES CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C.Cl
InChIKey YUKARLAABCGMCN-PKLMIRHRSA-N

Biological Activity

Tiagabine hydrochloride is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor that targets GABA transporter 1 (GAT-1). By selectively inhibiting GAT-1, tiagabine prevents GABA reuptake into presynaptic neurons and glial cells, thereby increasing extracellular GABA concentrations in synaptic clefts. This enhancement of central GABAergic inhibitory neurotransmission effectively attenuates neuronal hyperexcitability and suppresses seizure activity in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 82 mg/mL (199.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 82 mg/mL
Water 11 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Suzdak PD, et al. Epilepsia. 1995;36(6):612-26.

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Note: Technical data last updated: Sep 1, 2026.