CAS No. 1005178-02-8
Batch:
Purity:99.02
Chemical Structure
Check the
TI17
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 7-[[4-(pyridin-4-ylmethyl)phenyl]carbamoyl]tricyclo[3.2.2.02,4]non-8-ene-6-carboxylic acid | |
|---|---|---|
| CAS Number | 1005178-02-8 | |
| Molecular Formula |
C23H22N2O3 |
|
| Molecular Weight (MW) | 374.43 | |
| InChIKey | FTGODPNMSWLLKK-UHFFFAOYSA-N |
Biological Activity
TI17 is a small-molecule inhibitor targeting thyroid hormone receptor-interacting protein 13 (TRIP13), an AAA-ATPase essential for DNA double-strand break (DSB) repair. By impairing TRIP13 function, TI17 increases DNA damage responses, leading to cell cycle arrest at the G0/G1 phase and triggering apoptosis. This inhibition effectively suppresses cell proliferation and abrogates tumor growth in multiple myeloma models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(200.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.