CAS No. 1393-48-2

Batch: Purity:99.83
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Thiostrepton Chemical Structure
Chemical Structure
Check the Thiostrepton product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1393-48-2
Molecular Formula

C72H85N19O18S5
Molecular Weight (MW) 1664.89
SMILES CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C

Biological Activity

Thiostrepton is a natural cyclic oligopeptide antibiotic that acts as a selective inhibitor of the transcription factor FOXM1. By repressing FOXM1 expression and binding activity, thiostrepton suppresses downstream pathways regulating cell cycle progression and cell survival. Consequently, thiostrepton inhibits tumor cell proliferation and induces apoptosis in a wide range of human cancer cell lines, making it a valuable tool for studying FOXM1-mediated oncogenic signaling. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (60.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kwok JM, et al. Mol Cancer Ther. 2008;7(7):2022-32.

[2] Bhat UG, et al. PLoS One. 2009;4(8):e6593.

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Note: Technical data last updated: Sep 1, 2026.