CAS No. 5054-59-1
Batch:
Purity:99.97
Chemical Structure
Check the
Thalidomide-OH
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 5054-59-1 | |
|---|---|---|
| Molecular Formula |
C13H10N2O5 |
|
| Molecular Weight (MW) | 274.23 | |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)O |
Thalidomide-OH is a hydroxylated thalidomide metabolite and E3 ligase ligand that functions in recruiting Cereblon (CRBN). It acts as a CRBN binder for constructing proteolysis-targeting chimeras and exhibits weak antiangiogenic activity. Upon binding to CRBN, it regulates the CRL4-CRBN E3 ubiquitin ligase complex, promoting targeted substrate polyubiquitination and subsequent proteasomal degradation to modulate cellular processes. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
55 mg/mL
(200.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.