CAS No. 2763602-67-9
Batch:
Purity:98.05
Chemical Structure
Check the
TGFβRI-IN-3
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-(3-methylphenyl)-4-pyridinyl]-7-(4-methylsulfonylphenyl)quinolin-4-amine | |
|---|---|---|
| CAS Number | 2763602-67-9 | |
| Molecular Formula |
C28H23N3O2S |
|
| Molecular Weight (MW) | 465.57 | |
| SMILES | CC1=CC=CC(=C1)C2=CC(=CC=N2)NC3=CC=NC4=C3C=CC(=C4)C5=CC=C(C=C5)[S;v6](C)(=O)=O | |
| InChIKey | VYDDFPZEAIUBBH-UHFFFAOYSA-N |
TGFβRI-IN-is a potent and highly selective TGFβR1 inhibitor (IC50 = 0.79 nM) displaying 2000-fold selectivity against MAP4K4. By targeting TGFβR1, the compound suppresses downstream TGF-beta/Smad signaling pathways in the tumor microenvironment. This targeted inhibition counteracts TGF-beta-driven immunosuppressive signaling, mitigating peripheral immune tolerance and promoting T-cell activity for potential applications in immuno-oncology. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.