CAS No. 1124-11-4
Batch:
Purity:99.96
Chemical Structure
Check the
Tetramethylpyrazine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2,3,5,6-tetramethylpyrazine | |
|---|---|---|
| CAS Number | 1124-11-4 | |
| Molecular Formula |
C8H12N2 |
|
| Molecular Weight (MW) | 136.19 | |
| InChIKey | FINHMKGKINIASC-UHFFFAOYSA-N |
Tetramethylpyrazine is a natural pyrazine alkaloid compound exhibiting anti-inflammatory, antioxidant, antiplatelet, and anti-apoptotic activities. It modulates cellular function by inhibiting the NF-kB signaling pathway and activating the Nrf2 pathway, leading to down-regulation of pro-inflammatory cytokines and reduction of reactive oxygen species. Furthermore, tetramethylpyrazine suppresses vascular smooth muscle cell proliferation and inhibits platelet aggregation in preclinical disease models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(734.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | 4 mg/mL (超声加热五分钟，水浴60℃) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.