SMILES:

COC1=C(OC)C=C(\C=C\C(=O)C(C)(C)C(=O)\C=C\C2=CC(=C(OC)C=C2)OC)C=C1
Tetramethylcurcumin Chemical Structure
Chemical Structure
Check the Tetramethylcurcumin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione
CAS Number 52328-97-9
Molecular Formula

C25H28O6
Molecular Weight (MW) 424.49
SMILES COC1=C(OC)C=C(\C=C\C(=O)C(C)(C)C(=O)\C=C\C2=CC(=C(OC)C=C2)OC)C=C1
InChIKey VMMZAMVBGQWOHT-UTLPMFLDSA-N

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 85 mg/mL (200.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.