CAS No. 6024-85-7

Batch: Purity:99.74
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Tetrahydropalmatine hydrochloride Chemical Structure
Chemical Structure
Check the Tetrahydropalmatine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline;hydrochloride
CAS Number 6024-85-7
Molecular Formula

C21H25NO4.HCl
Molecular Weight (MW) 391.89
SMILES COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC.Cl
InChIKey MGSZZQQRTPWMEI-UHFFFAOYSA-N

Ordering Information

Biological Activity

Tetrahydropalmatine hydrochloride is a natural isoquinoline alkaloid that functions as an antagonist of central dopamine receptors. It inhibits dopamine release within brain structures such as the amygdala, suppressing hyperactive dopaminergic pathway signaling. Downstream, this action attenuates central nervous system excitation, resulting in muscle relaxation, sedative activities, and inhibition of epileptic seizures in animal models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 12 mg/mL (30.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.