CAS No. 163451-81-8

Batch: Purity:99.99
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Teriflunomide Chemical Structure
Chemical Structure
Check the Teriflunomide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 163451-81-8
Molecular Formula

C12H9F3N2O2
Molecular Weight (MW) 270.21
SMILES CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O

Ordering Information

Biological Activity

Teriflunomide (A77 1726) is an immunomodulatory agent and a potent inhibitor of dihydroorotate dehydrogenase (DHODH), the key enzyme in de novo pyrimidine synthesis. By blocking DHODH activity in mitochondria, it depletes intracellular pyrimidine nucleotide pools, suppressing DNA and RNA synthesis in rapidly proliferating cells. This action leads to G1 cell cycle arrest and inhibition of activated T and B lymphocyte proliferation without inducing cell death. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 27 mg/mL (99.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.