CAS No. 206184-49-8

Batch: Purity:99.82
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Tenofovir hydrate Chemical Structure
Chemical Structure
Check the Tenofovir hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid;hydrate
CAS Number 206184-49-8
Molecular Formula

C9H16N5O5P
Molecular Weight (MW) 305.23
SMILES O.CC(C[N]1C=NC2=C(N)N=CN=C12)OC[P](O)(O)=O
InChIKey PINIEAOMWQJGBW-FYZOBXCZSA-N

Biological Activity

Tenofovir hydrate is a nucleotide reverse transcriptase inhibitor that targets HIV-1 reverse transcriptase and hepatitis B virus polymerase. Following intracellular conversion to its active diphosphate form, it competes with natural deoxyadenosine triphosphate for incorporation into viral DNA. Incorporation of this metabolite results in DNA chain termination, thereby blocking viral genome replication and suppressing hepatitis B virus infections. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 10 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] J. Med. Virol. 2000;61(2):280-280.

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Note: Technical data last updated: Sep 1, 2026.