Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase 1 (GLS1) inhibitor. It affects ATF4/CHOP, AMPK, and mTOR signaling pathways by blocking glutaminolysis and depleting TCA cycle intermediates, effectively inhibiting cancer cell proliferation and inducing apoptosis.
Telaglenastat (CB-839) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Telaglenastat (CB-839) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.