CAS No. 1439399-58-2
| IUPAC Name | N-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide | |
|---|---|---|
| CAS Number | 1439399-58-2 | |
| Molecular Formula |
C26H24F3N7O3S |
|
| Molecular Weight (MW) | 571.57 | |
| SMILES | C1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F | |
| InChIKey | PRAAPINBUWJLGA-UHFFFAOYSA-N |
Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor that targets recombinant human GAC with an IC50 of. It blocks the conversion of glutamine to glutamate within the glutamine metabolism pathway, disrupting downstream tricarboxylic acid cycle intermediate replenishment and energy production. This metabolic inhibition leads to antiproliferative effects, induction of autophagy, and robust antitumor activity in preclinical cancer models. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(174.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(174.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(174.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(174.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(174.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Telaglenastat (CB-839) Mechanism of Action: Glutaminase Inhibition in Tumor Cell Research
- Telaglenastat (CB-839) Clinical Trials
- Telaglenastat (CB-839) Working Concentration | Cell Culture | Treatment
- Telaglenastat (CB-839) Solubility in DMSO
- Telaglenastat (CB-839) Stock Solution
- Telaglenastat (CB-839) Storage
- Telaglenastat (CB-839) Stability
- Telaglenastat (CB-839) Combination Database
- Telaglenastat (CB-839) Molecular Weight
- Telaglenastat (CB-839) SMILES
- Telaglenastat (CB-839) Chemical Structure (2D and 3D)
- Telaglenastat (CB-839) IC50 for Cell-based and Cell-free Assays
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- Telaglenastat (CB-839) SDS｜MSDS