CAS No. 189188-57-6
Batch:
Purity:99.89
Chemical Structure
Check the
Tegaserod Maleate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (Z)-but-2-enedioic acid;1-[(E)-(5-methoxy-1H-indol-3-yl)methylideneamino]-2-pentylguanidine | |
|---|---|---|
| CAS Number | 189188-57-6 | |
| Molecular Formula |
C16H23N5O.C4H4O4 |
|
| Molecular Weight (MW) | 417.46 | |
| SMILES | CCCCCN=C(N)NN=CC1=CNC2=C1C=C(C=C2)OC.C(=CC(=O)O)C(=O)O | |
| InChIKey | CPDDZSSEAVLMRY-FEQFWAPWSA-N |
Tegaserod Maleate is a selective, high-affinity partial agonist of the 5-HT4 receptor with negligible affinity for other serotonin receptor subtypes or muscarinic and dopaminergic receptors. Activation of 5-HT4 receptors by Tegaserod stimulates adenylate cyclase, increasing intracellular cAMP levels and triggering downstream protein kinase A activation. This signaling pathway promotes neurotransmitter release in the enteric nervous system, enhancing gastrointestinal motility and stimulating peristaltic reflexes.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(198.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.