CAS No. 17328-16-4

Batch: Purity:99.56
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TC-E 5003 Chemical Structure
Chemical Structure
Check the TC-E 5003 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-chloro-N-[4-[4-[(2-chloroacetyl)amino]phenyl]sulfonylphenyl]acetamide
CAS Number 17328-16-4
Molecular Formula

C16H14Cl2N2O4S
Molecular Weight (MW) 401.26
SMILES ClCC(=O)NC1=CC=C(C=C1)[S](=O)(=O)C2=CC=C(NC(=O)CCl)C=C2
InChIKey SHRCVZJKZJGIHQ-UHFFFAOYSA-N

Ordering Information

Biological Activity

TC-E 5003 is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 of. By inhibiting PRMT1 catalytic activity, this compound modulates lipopolysaccharide-induced AP-1 and NF-κB signaling pathways. Downstream, target inhibition attenuates the expression of pro-inflammatory cytokines and mediators, demonstrating significant anti-inflammatory activity and providing a valuable chemical tool for investigating arginine methylation dynamics in disease models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (199.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.