CAS No. 1467052-75-0

Batch: Purity:99.50
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Tazemetostat hydrobromide Chemical Structure
Chemical Structure
Check the Tazemetostat hydrobromide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide;hydrobromide
CAS Number 1467052-75-0
Molecular Formula

C34H44N4O4.BrH
Molecular Weight (MW) 653.65
InChIKey UQRICAQPWZSJNF-UHFFFAOYSA-N

Ordering Information

Biological Activity

Tazemetostat hydrobromide (EPZ-6438 hydrobromide) is a potent, selective, orally available EZH2 inhibitor that inhibits EZH2 with IC50 values ofin peptide assays andin nucleosome assays, while inhibiting EZH1 with an IC50 of. By blocking EZH2 catalytic activity, it decreases histone H3 lysine 27 trimethylation (H3K27me3), suppressing polycomb repressive complex 2 (PRC2)-mediated transcriptional silencing and inducing anti-proliferative phenotypes in target cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (152.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.