CAS No. 1403254-99-8
Batch:
Purity:99.90
Chemical Structure
Check the
EPZ-6438 (Tazemetostat)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide | |
|---|---|---|
| CAS Number | 1403254-99-8 | |
| Molecular Formula |
C34H44N4O4 |
|
| Molecular Weight (MW) | 572.74 | |
| SMILES | CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5 | |
| InChIKey | NSQSAUGJQHDYNO-UHFFFAOYSA-N |
EPZ-6438 (Tazemetostat) is a potent and selective EZH2 inhibitor with a Ki ofand an IC50 of. It exhibits 35-fold selectivity over EZH1 and greater than 4,500-fold selectivity over 14 other histone methyltransferases. By blocking EZH2 catalytic activity, EPZ-6438 decreases trimethylation of histone H3 lysine 27 (H3K27me3), restoring tumor suppressor gene expression and inducing growth arrest and apoptosis in EZH2-mutant lymphoma cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(174.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(174.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(174.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(174.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(174.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- EPZ-6438 (Tazemetostat) Mechanism of Action: EZH2 Inhibition in B-Cell Research
- EPZ-6438 (Tazemetostat) Clinical Trials
- EPZ-6438 (Tazemetostat): Selectivity & Specificity
- EPZ-6438 (Tazemetostat) Working Concentration | Cell Culture | Treatment
- EPZ-6438 (Tazemetostat) Solubility in DMSO
- EPZ-6438 (Tazemetostat) Stock Solution
- EPZ-6438 (Tazemetostat) Storage
- EPZ-6438 (Tazemetostat) Stability
- EPZ-6438 (Tazemetostat) VS GSK126 | 3-Deazaneplanocin A (DZNep) Hydrochloride
- EPZ-6438 (Tazemetostat) Molecular Weight
- EPZ-6438 (Tazemetostat) SMILES
- EPZ-6438 (Tazemetostat) Chemical Structure (2D and 3D)
- EPZ-6438 (Tazemetostat) IC50 for Cell-based and Cell-free Assays
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- EPZ-6438 (Tazemetostat) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.