CAS No. 254964-60-8

Batch: Purity:99.94
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Tasquinimod Chemical Structure
Chemical Structure
Check the Tasquinimod product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]quinoline-3-carboxamide
CAS Number 254964-60-8
Molecular Formula

C20H17F3N2O4
Molecular Weight (MW) 406.36
SMILES CN1C2=C(C(=CC=C2)OC)C(=C(C1=O)C(=O)N(C)C3=CC=C(C=C3)C(F)(F)F)O
InChIKey ONDYALNGTUAJDX-UHFFFAOYSA-N

Ordering Information

Biological Activity

Tasquinimod (ABR-215050) is an orally active antiangiogenic agent that acts as an allosteric inhibitor of HDAC4 signaling and also targets S100A9. By modulating HDAC4 pathways and disrupting S100A9 interactions, it inhibits tumor angiogenesis, suppresses myeloid-derived suppressor cell infiltration, and alters the tumor microenvironment. These cellular actions suppress tumor growth and vascularization across various cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 81 mg/mL (199.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.