CAS No. 1207456-01-6
Batch:
Purity:99.88
Chemical Structure
Check the
BMN-673 (Talazoparib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8-tetraen-4-one | |
|---|---|---|
| CAS Number | 1207456-01-6 | |
| Molecular Formula |
C19H14F2N6O
|
|
| Molecular Weight (MW) | 380.35 | |
| SMILES | CN1C(=NC=N1)C2C(NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F | |
| InChIKey | HWGQMRYQVZSGDQ-HZPDHXFCSA-N |
Talazoparib (BMN-673) is a potent inhibitor of PARP1 (IC50 0.57 nM) and PARP2. By selectively binding to PARP enzymes and trapping PARP-DNA complexes, it blocks single-strand DNA break repair and disrupts base excision repair pathways. This trapping leads to persistent double-strand breaks during replication, driving synthetic lethality and cell death in homologous recombination-deficient tumors. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
19 mg/mL
(49.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
76 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
76 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
19 mg/mL
(49.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
76 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- BMN-673 (Talazoparib) Mechanism of Action: PARP Inhibition in Prostate Cancer Cell Research
- BMN-673 (Talazoparib) Clinical Trials
- BMN-673 (Talazoparib): Selectivity & Specificity
- BMN-673 (Talazoparib) Working Concentration | Cell Culture | Treatment
- BMN-673 (Talazoparib) Solubility in DMSO
- BMN-673 (Talazoparib) Stock Solution
- BMN-673 (Talazoparib) Storage
- BMN-673 (Talazoparib) Stability
- BMN-673 (Talazoparib) Combination Database
- BMN-673 (Talazoparib) Molecular Weight
- BMN-673 (Talazoparib) SMILES
- BMN-673 (Talazoparib) Chemical Structure (2D and 3D)
- BMN-673 (Talazoparib) IC50 for Cell-based and Cell-free Assays
- BMN-673 (Talazoparib) MedChemExpress (HY-16106)? Try a better option.
- BMN-673 (Talazoparib) Cayman (19782)? Try a better option.
- BMN-673 (Talazoparib) Abmole (M1732)? Try a better option.
- BMN-673 (Talazoparib) Cell Signaling Technology (80577)? Try a better option.
- BMN-673 (Talazoparib) Sigma (AABH9A9550C4)? Try a better option.
- BMN-673 (Talazoparib) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.