CAS No. 20501-56-8
Batch:
Purity:99.87
Chemical Structure
Check the
Talatisamine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1S,2R,3R,4S,5S,6S,8S,9S,13S,16S,17R)-11-ethyl-6,16-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,8-diol | |
|---|---|---|
| CAS Number | 20501-56-8 | |
| Molecular Formula |
C24H39NO5 |
|
| Molecular Weight (MW) | 421.57 | |
| SMILES | CCN1CC2(CCC(C34C2CC(C31)C5(CC(C6CC4C5C6O)OC)O)OC)COC | |
| InChIKey | BDCURAWBZJMFIK-FLDLCTCNSA-N |
Talatisamine is a natural diterpene alkaloid extracted from Aconitum talassicum that acts as a potassium channel blocker. By inhibiting voltage-gated potassium channels, it modulates membrane excitability and ion flux across cell membranes. These cellular actions suppress abnormal cardiac action potentials and regulate vascular tone, mediating downstream antiarrhythmic and hypotensive activities in functional assays. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
35 mg/mL
(83.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
35 mg/mL
(83.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.