CAS No. 1137868-52-0
Batch:
Purity:99.92
Chemical Structure
Check the
TAK-960
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide | |
|---|---|---|
| CAS Number | 1137868-52-0 | |
| Molecular Formula |
C27H34F3N7O3 |
|
| Molecular Weight (MW) | 561.6 | |
| SMILES | COC1=C(NC2=NC=C3N(C)C(=O)C(F)(F)CN(C4CCCC4)C3=N2)C=C(F)C(=C1)C(=O)NC5CCN(C)CC5 | |
| InChIKey | GWRSATNRNFYMDI-UHFFFAOYSA-N |
Biological Activity
TAK-960 is an orally bioavailable, potent, and selective polo-like kinase 1 (PLK1) inhibitor. By inhibiting PLK1, TAK-960 disrupts mitotic progression, causing cell cycle arrest at the G2/M phase, accumulation of aberrant polo mitosis morphology, and elevated phosphorylation of histone H3. These downstream mitotic defects lead to the inhibition of cancer cell proliferation and potent antitumor activity in multiple tumor xenograft models, including multidrug-resistant malignancies. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
13 mg/mL
(23.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.