CAS No. 1952251-28-3

Batch: Purity:99.65
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TAK-659 Hydrochloride Chemical Structure
Chemical Structure
Check the TAK-659 Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one;hydrochloride
CAS Number 1952251-28-3
Molecular Formula

C17H21FN6 .HCl
Molecular Weight (MW) 380.85
SMILES CN1C=C(C=N1)C2=NC(=C(C3=C2C(=O)NC3)F)NC4CCCCC4N.Cl
InChIKey PTCFBXMEFRIEGV-ZVWHLABXSA-N

Ordering Information

Biological Activity

TAK-659 Hydrochloride is a potent inhibitor of spleen tyrosine kinase (SYK) with an IC50 of 3.2 nM, while also displaying potent activity against FLT3. By blocking SYK signaling within the B-cell receptor pathway, TAK-659 disrupts downstream AKT/mTOR and ERK activation cascades. This pathway suppression leads to inhibited cellular proliferation, microenvironment signal disruption, and increased apoptosis in hematologic malignancy models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 2 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.