CAS No. 29479-00-3

Batch: Purity:98
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Tabersonine hydrochloride Chemical Structure
Chemical Structure
Check the Tabersonine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl (1R,12R,19S)-12-ethyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,9,13-pentaene-10-carboxylate;hydrochloride
CAS Number 29479-00-3
Molecular Formula

C21H24N2O2.HCl
Molecular Weight (MW) 372.89
SMILES CCC12CC(=C3C4(C1N(CC4)CC=C2)C5=CC=CC=C5N3)C(=O)OC.Cl
InChIKey BBASQSWPQOKOQI-OCIDDWSYSA-N

Ordering Information

Biological Activity

Tabersonine hydrochloride is a natural indole alkaloid that acts as an inhibitor of amyloid-beta 1-42 (Aβ1-42) aggregation and associated cellular toxicity. It inhibits Aβ1-42 self-assembly into cytotoxic oligomers and destabilizes preformed aggregates. Furthermore, tabersonine suppresses downstream NF-kB and MAPK signaling pathways, leading to reduced production of pro-inflammatory cytokines and attenuated inflammatory cell damage.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 75 mg/mL (201.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.