CAS No. 222716-34-9
Batch:
Purity:99.57
Chemical Structure
Check the
SZL P1-41
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-8-(piperidin-1-ylmethyl)chromen-4-one | |
|---|---|---|
| CAS Number | 222716-34-9 | |
| Molecular Formula |
C24H24N2O3S |
|
| Molecular Weight (MW) | 420.52 | |
| SMILES | CCC1=C(O)C(=C2OC=C(C(=O)C2=C1)C3=NC4=C(S3)C=CC=C4)CN5CCCCC5 | |
| InChIKey | JKIXLEKBXHMXTN-UHFFFAOYSA-N |
SZL P1-41 is a specific small-molecule inhibitor of S-phase kinase-associated protein 2 (Skp2). It directly binds to Skp2 and disrupts the Skp2-Skp1 interaction, thereby inhibiting Skp2 SCF E3 ubiquitin ligase activity. This functional inhibition impairs downstream oncogenic pathways, resulting in the suppression of cancer cell and cancer stem cell survival and the induction of apoptotic cell death. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(11.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.