CAS No. 5985-28-4
| CAS Number | 5985-28-4 | |
|---|---|---|
| Molecular Formula |
C9H13NO2.HCl |
|
| Molecular Weight (MW) | 203.67 | |
| SMILES | CNCC(C1=CC=C(C=C1)O)O.Cl |
Synephrine HCl (Oxedrine) is a sympathomimetic α-adrenergic receptor agonist. It targets α1- and α2-adrenoreceptors, displaying substantially lower binding affinity compared to norepinephrine. Activation of vascular α-adrenoceptors by Synephrine stimulates downstream vasoconstriction in isolated aortas and splanchnic vasculature. Consequently, this signaling mechanism reduces portal pressure, ameliorates portal hypertension, and suppresses systemic hyperemic states in cirrhotic and portal hypertensive models.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Water | 41 mg/mL |
| DMSO |
14 mg/mL
(68.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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