CAS No. 2070015-26-6
Batch:
Purity:99.72
Chemical Structure
Check the
SRT3025 HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2070015-26-6 | |
|---|---|---|
| Molecular Formula |
C31H31N5O2S2.HCl |
|
| Molecular Weight (MW) | 606.2 | |
| SMILES | COCCCC1=C(N=C(S1)C2=CC=CC=C2)C(=O)NC3=CC=CC=C3C4=NC5=C(S4)N=CC(=C5)CN6CCCC6.Cl |
SRT3025 HCl is an orally bioavailable small-molecule activator of the NAD+-dependent deacetylase sirtuin 1 (SIRT1). By enhancing SIRT1 enzymatic activity, it promotes the deacetylation of downstream targets such as PGC-1alpha and p53, thereby modulating cellular metabolic homeostasis, oxidative stress responses, and gene expression pathways involved in lipid regulation and energy expenditure. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(164.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.