CAS No. 1629138-41-5

Batch: Purity:99.62
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SRI-011381 (C381) Chemical Structure
Chemical Structure
Check the SRI-011381 (C381) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea
CAS Number 1629138-41-5
Molecular Formula
C20H31N3O
 
Molecular Weight (MW) 329.48
SMILES C1CCC(CC1)NC(=O)N(CC2CCNCC2)CC3=CC=CC=C3
InChIKey LNOPAJNGRAPFKZ-UHFFFAOYSA-N

Ordering Information

Biological Activity

SRI-011381 (C381) is a small-molecule agonist of the TGF-β signaling pathway designed for neurodegenerative conditions such as Alzheimer's disease. The compound physically targets lysosomes to promote lysosomal acidification, enhancing the breakdown of lysosomal cargo and improving lysosomal resilience against cellular damage. Activation of TGF-β signaling promotes microglial function and facilitates amyloid-β clearance, contributing to neuroprotective outcomes in preclinical models of neurodegeneration. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (200.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 66 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.