CAS No. 502487-67-4
Batch:
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Chemical Structure
Check the
SQ109
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N'-(2-adamantyl)-N-[(2E)-3,7-dimethylocta-2,6-dienyl]ethane-1,2-diamine | |
|---|---|---|
| CAS Number | 502487-67-4 | |
| Molecular Formula |
C22H38N2 |
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| Molecular Weight (MW) | 330.55 | |
| SMILES | CC(C)=CCC/C(C)=C/CNCCNC1C2CC3CC(C2)CC1C3 | |
| InChIKey | JFIBVDBTCDTBRH-REZTVBANSA-N |
Biological Activity
SQ109 is an orally active small-molecule antibiotic that targets mycobacterial membrane protein large 3 (MmpL3) in Mycobacterium tuberculosis and exhibits activity against culture-derived trypomastigotes with an IC50 of. By inhibiting MmpL3, SQ109 disrupts mycolic acid transport across the cell envelope, leading to compromised cell wall integrity, inhibition of cell wall biosynthesis, and suppression of bacterial proliferation. [1]
How to Prepare Stock Solution?
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Concentration
Volume
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Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
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Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.