Spironolactone has been evaluated in numerous clinical trials spanning early through late phases for indications such as heart failure, hypertension, acute myocardial infarction, alcohol use disorder, and polycystic ovary syndrome. Sponsored by academic centers, hospital networks, government health organizations, and commercial developers, these trials reflect recruitment statuses ranging from completed to actively recruiting or not yet recruiting. Completed late-phase clinical trials have evaluated post-myocardial infarction cardiovascular outcomes, whereas early-phase studies continue to explore novel therapeutic applications.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT07020104 | RECRUITING | Chronic Kidney Diseases |
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
2025-01-07 | |
| NCT07645300 | NOT_YET_RECRUITING | Hypertension Treated With Antihypertensive Drugs; Chronic Kidney Disease, 3B and 4 |
VA Office of Research and Development |
2026-10-01 | PHASE2 |
| NCT07539259 | NOT_YET_RECRUITING | Aortic Stenosis |
University College, London |
2026-12 | PHASE2 |
| NCT03984591 | ENROLLING_BY_INVITATION | Systolic Heart Failure |
Bispebjerg Hospital |
2020-11-01 | PHASE4 |
| NCT07483177 | RECRUITING | Thoracic Aortic Aneurysm |
Mayo Clinic |
2026-05-25 | PHASE1; PHASE2 |
| NCT07585526 | NOT_YET_RECRUITING | MASLD; Chronic Kidney Diseases |
Institute of Liver and Biliary Sciences, India |
2026-04-15 | |
| NCT07304817 | RECRUITING | CKD; Cardiovascular Diseases; Heart Failure |
University Medical Center Groningen |
2026-05-12 | PHASE2 |
| NCT07687160 | NOT_YET_RECRUITING | Hypertension |
Ottawa Hospital Research Institute |
2026-09-01 | PHASE4 |
| NCT06204640 | NOT_YET_RECRUITING | Atrial Fibrillation Recurrent |
University Hospital, Caen |
2024-03-01 | PHASE3 |
| NCT07041281 | RECRUITING | Preeclampsia; Gestational Hypertension |
Massachusetts General Hospital |
2025-10-16 | PHASE2 |
| NCT07715318 | NOT_YET_RECRUITING | Anemia |
Ain Shams University |
2026-12-01 | PHASE2 |
| NCT03593317 | RECRUITING | Arrhythmogenic Right Ventricular Dysplasia |
Hospices Civils de Lyon |
2024-12-20 | PHASE2 |
| NCT07281014 | ACTIVE_NOT_RECRUITING | Heart Failure |
Yale University |
2026-01-27 | PHASE4 |
| NCT07431216 | NOT_YET_RECRUITING | Glioblastoma (GBM) |
Starlight Therapeutics Inc. |
2026-05-01 | PHASE1; PHASE2 |
| NCT07688928 | RECRUITING | Primary Aldosteronism; Endocrine Hypertension |
Bangladesh Medical University |
2026-04-15 | |
| NCT01712620 | RECRUITING | Pulmonary Arterial Hypertension |
National Institutes of Health Clinical Center (CC) |
2014-01-10 | PHASE2 |
| NCT05807139 | RECRUITING | Alcohol Use Disorder |
National Institute on Drug Abuse (NIDA) |
2023-07-13 | PHASE1 |
| NCT06678685 | RECRUITING | NCOR Gene Mutations; Spironolactone; ASD |
Qilu Hospital of Shandong University |
2024-10-30 | PHASE2; PHASE3 |
| NCT02901184 | RECRUITING | Heart Failure With Preserved Ejection Fraction |
Uppsala University |
2017-11-23 | PHASE3 |
| NCT07523867 | NOT_YET_RECRUITING | Heart Failure; Diabetic Kidney Disease; Hyperkalemia |
Hospital de Messejana Dr. Carlos Alberto Studart Gomes |
2026-04 | PHASE4 |
| NCT07473895 | NOT_YET_RECRUITING | Acne Vulgaris |
Assiut University |
2026-04 | PHASE2 |
| NCT07223502 | RECRUITING | Hypertension (HTN) |
Sarfez Pharmaceuticals, Inc. |
2025-12-01 | PHASE3 |
| NCT04901975 | COMPLETED | Single-ventricle |
Children's Hospital of Philadelphia |
2021-02-11 | PHASE1; PHASE2 |
| NCT06035978 | UNKNOWN | Cardiovascular Diseases; Heart Failure With Reduced Ejection Fraction |
University Hospital Ostrava |
2024-03 | PHASE4 |
| NCT05092984 | RECRUITING | Rheumatoid Arthritis |
University Hospital, Strasbourg, France |
2022-06-22 | PHASE3 |
| NCT07046975 | COMPLETED | Bioavailability Heathy Volunteers |
Sarfez Pharmaceuticals, Inc. |
2025-06-15 | PHASE3 |
| NCT04582383 | ACTIVE_NOT_RECRUITING | Acne |
University of Pennsylvania |
2022-03-30 | PHASE4 |
| NCT04760717 | ACTIVE_NOT_RECRUITING | Intracerebral Hemorrhage; Ischemic Stroke; Spironolactone |
Yale University |
2021-03-19 | PHASE2 |
| NCT06004830 | COMPLETED | Alcohol Use Disorder; Hiv |
Yale University |
2023-11-06 | PHASE2 |
| NCT07328230 | RECRUITING | Idiopathic Hyperaldosteronism; Hyperaldosteronism |
Chinese Academy of Medical Sciences, Fuwai Hospital |
2022-08-01 | |
| NCT05754684 | RECRUITING | Neuroblastoma Recurrent |
Hong Kong Children's Hospital |
2022-01-01 | PHASE2 |
| NCT06523465 | RECRUITING | Primary Aldosteronism; Statin; Mineralocorticoid Receptor Antagonist; Hypertension |
Third Military Medical University |
2024-09-10 | PHASE4 |
| NCT07043634 | COMPLETED | Bioavailability Heathy Volunteers |
Sarfez Pharmaceuticals, Inc. |
2025-06-15 | PHASE3 |
| NCT07015671 | COMPLETED | Bioequivalence Study in Healthy Subjects; PK/PD |
Sarfez Pharmaceuticals, Inc. |
2025-07-01 | PHASE3 |
| NCT06275763 | UNKNOWN | Hypertension |
National Institute of Cardiology, Warsaw, Poland |
2023-10-20 | PHASE4 |
| NCT03429946 | COMPLETED | Hypoglycemia; Healthy |
Brigham and Women's Hospital |
2013-07-17 | PHASE4 |
| NCT06499948 | COMPLETED | Alport Syndrome; Thin Basement Membrane Disease; Alport Nephropathy |
Stefan Lujinschi |
2024-02-26 | PHASE4 |
| NCT06005259 | UNKNOWN | Cardiotoxicity; Neoplasms; Chemotherapy Effect; Heart Failure |
University of Sao Paulo |
2023-10-01 | PHASE4 |
| NCT04723862 | RECRUITING | Hyperandrogenism; Polycystic Ovary Syndrome; Puberty |
University of Virginia |
2021-11-12 | EARLY_PHASE1 |
| NCT03068910 | RECRUITING | Hyperandrogenism; Polycystic Ovary Syndrome; Puberty |
University of Virginia |
2016-07-21 | EARLY_PHASE1 |
| NCT04522739 | COMPLETED | Mild Cognitive Impairment; Alzheimer Disease |
Emory University |
2022-09-06 | PHASE4 |
| NCT05501080 | RECRUITING | Primary Aldosteronism |
Second Affiliated Hospital of Nanchang University |
2022-09-01 | |
| NCT03929718 | ACTIVE_NOT_RECRUITING | AFib |
Piedmont Healthcare |
2019-04-24 | EARLY_PHASE1 |
| NCT06457074 | UNKNOWN | Primary Aldosteronism |
Qifu Li |
2024-06-04 | PHASE4 |
| NCT05230901 | UNKNOWN | Aortic Stenosis, Severe |
University Medical Center Goettingen |
2022-02-23 | PHASE3 |
| NCT05394142 | UNKNOWN | Polycystic Ovary Syndrome (PCOS) |
Fundació Sant Joan de Déu |
2022-05-24 | PHASE2 |
| NCT03020303 | COMPLETED | Endstage Renal Disease |
Hamilton Health Sciences Corporation |
2017-07-07 | PHASE3 |
| NCT05814770 | UNKNOWN | Primary Aldosteronism; Hypertension |
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School |
2023-05 | PHASE4 |
| NCT06021860 | UNKNOWN | Edema Due to Heart Failure or Cirrhosis |
CMP Development, LLC |
2024-06 | PHASE4 |
| NCT04409431 | UNKNOWN | Primary Aldosteronism; Hypertension |
Third Military Medical University |
2019-12-01 | |
| NCT06164379 | UNKNOWN | Primary Aldosteronism |
Shanghai Jiao Tong University School of Medicine |
2023-12-16 | PHASE4 |
| NCT07415811 | ENROLLING_BY_INVITATION | HIV |
University of Sao Paulo General Hospital |
2024-07-24 | |
| NCT01422759 | UNKNOWN | Obesity; Hyperandrogenemia; Polycystic Ovary Syndrome |
University of Virginia |
2016-12-09 | |
| NCT05676684 | COMPLETED | Heart Failure With Preserved Ejection Fraction |
Universidade do Porto |
2022-09-15 | PHASE2; PHASE3 |
| NCT04727073 | TERMINATED | Heart Failure with Mid-range Ejection Fraction; Heart Failure with Preserved Ejection Fraction |
Charite University, Berlin, Germany |
2018-11-01 | PHASE3 |
| NCT04075149 | UNKNOWN | Polycystic Ovary Syndrome; Puberty Disorders; Ovulation Disorder |
University of Virginia |
2019-12-18 | EARLY_PHASE1 |
| NCT03048825 | COMPLETED | ST Elevation Myocardial Infarction; Non ST Elevation Myocardial Infarction |
Population Health Research Institute |
2018-02-01 | PHASE3 |
| NCT04676646 | COMPLETED | Hyperkalaemia; Heart Failure With Reduced Ejection Fraction |
AstraZeneca |
2021-03-08 | PHASE4 |
| NCT06021860 | Not yet recruiting | Edema Due to Heart Failure or Cirrhosis |
CMP Development LLC |
2024-06 | Phase 4 |
| NCT04331691 | COMPLETED | Resistant Hypertension |
Yonsei University |
2020-11-16 | PHASE4 |
| NCT05849766 | COMPLETED | Dilated Cardiomyopathy |
October 6 University |
2023-04-27 | PHASE3 |
| NCT06205407 | COMPLETED | Healthy Participants |
Pfizer |
2023-12-26 | PHASE1 |
| NCT06204640 | Not yet recruiting | Atrial Fibrillation Recurrent |
University Hospital Caen |
2024-03-01 | Phase 3 |
| NCT05995392 | UNKNOWN | Dry Eye Disease |
Richard W Yee, MD |
2023-08 | EARLY_PHASE1 |
| NCT04455178 | UNKNOWN | Hypertension |
Shanghai Jiao Tong University School of Medicine |
2020-09-23 | PHASE4 |
| NCT05222191 | UNKNOWN | Renal Insufficiency; Chronic Hypertension |
Indiana Institute for Medical Research |
2022-02-01 | PHASE2 |
| NCT03867682 | UNKNOWN | Acute Myeloid Leukemia; Relapsed Adult AML |
Actinium Pharmaceuticals |
2020-01-15 | PHASE1; PHASE2 |
| NCT05010707 | COMPLETED | Transgenderism |
Washington University School of Medicine |
2021-08-02 | PHASE2 |
| NCT06413082 | COMPLETED | Hypertension; Genetic Predisposition; Drug Effect |
Ospedale San Raffaele |
2021-02-15 | PHASE3 |
| NCT03576755 | COMPLETED | NASH - Nonalcoholic Steatohepatitis |
University of California, San Francisco |
2019-01-09 | PHASE1; PHASE2 |
| NCT05807139 | Recruiting | Alcohol Use Disorder |
National Institute on Drug Abuse (NIDA)|National Institutes of Health Clinical Center (CC) |
2023-07-13 | Phase 1 |
| NCT06579053 | COMPLETED | Bioequivalence Study |
SPH Sine Pharmaceutical Laboratories Co., Ltd. |
2023-03-22 | PHASE1 |
| NCT04190433 | WITHDRAWN | Breast Carcinoma; Hematopoietic and Lymphoid Cell Neoplasm; Lymphoma; Sarcoma |
Mayo Clinic |
2020-09-01 | PHASE2 |
| NCT04205136 | WITHDRAWN | Obstructive Sleep Apnea |
University of Michigan |
2022-03 | PHASE4 |
| NCT03334682 | COMPLETED | Acne Vulgaris |
Nantes University Hospital |
2018-01-31 | PHASE3 |
| NCT01848639 | COMPLETED | End Stage Renal Failure on Dialysis |
University Hospital, Brest |
2013-06 | PHASE3 |
| NCT04283656 | COMPLETED | Transgender Health; Gender Dysphoria; Transgender Women; Human Immunodeficiency Virus |
Thomas Jefferson University |
2022-01-04 | PHASE1 |
| NCT03502031 | UNKNOWN | Renal Insufficiency, Chronic; Diabetic Nephropathy Type 2 |
James A. Tumlin, MD |
2018-10-01 | PHASE4 |
| NCT04853355 | WITHDRAWN | Diabetic Maculopathy |
Wake Forest University Health Sciences |
2022-07 | PHASE4 |
| NCT03344159 | COMPLETED | Chronic Right-Sided Heart Failure; Pulmonary Arterial Hypertension; Pulmonary Hypertension, Primary, 2; Pulmonary Hypertension, Primary, 3; Pulmonary Hypertension, Primary, 4; Cardiomyopathy Right Ventricular |
Ottawa Heart Institute Research Corporation |
2018-04-01 | PHASE4 |
| NCT04465123 | UNKNOWN | Acute Heart Failure; Acute Kidney Injury |
Chiang Mai University |
2020-08-13 | PHASE3 |
| NCT05092984 | Recruiting | Rheumatoid Arthritis |
University Hospital Strasbourg France |
2022-06-22 | Phase 3 |
| NCT04327232 | UNKNOWN | Atrial Fibrillation |
National University Hospital, Singapore |
2018-05-23 | PHASE2 |
| NCT02169089 | COMPLETED | Atherosclerosis |
University Hospitals Cleveland Medical Center |
2016-01 | PHASE4 |
| NCT04618601 | UNKNOWN | Heart Failure Acute; Heart Failure; With Decompensation |
Laikο General Hospital, Athens |
2020-10-20 | PHASE4 |
| NCT04367051 | COMPLETED | Heart Failure |
Asan Medical Center |
2020-08-13 | |
| NCT04643691 | TERMINATED | COVID-19; ARDS |
Assistance Publique Hopitaux De Marseille |
2020-09-11 | PHASE2 |
| NCT04723862 | Recruiting | Hyperandrogenism|Polycystic Ovary Syndrome|Puberty |
University of Virginia|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
2021-11-12 | Early Phase 1 |
| NCT03777319 | TERMINATED | Muscular Dystrophy, Duchenne |
Kevin Flanigan |
2018-12-05 | PHASE1 |
| NCT04912011 | UNKNOWN | COVID-19 Pneumonia |
Pomeranian Medical University Szczecin |
2021-01-01 | PHASE4 |
| NCT04826822 | UNKNOWN | Coronavirus Infection; Pneumonia, Viral |
Chita State Regional Clinical Hospital Number 1 |
2021-02-24 | PHASE3 |
| NCT03551548 | UNKNOWN | Cardiac Surgery; Atrial Fibrillation; Aldosterone Blockade |
University Hospital, Caen |
2019-02-26 | PHASE3 |
| NCT02497300 | COMPLETED | Chronic Kidney Disease; Albuminuria |
University of Alabama at Birmingham |
2015-03 | PHASE2 |
| NCT04100083 | WITHDRAWN | Hidradenitis Suppurativa |
Medical University of South Carolina |
2020-09-21 | PHASE4 |
| NCT01602861 | COMPLETED | Disorder Related to Renal Transplantation |
Odense University Hospital |
2013-02 | PHASE4 |
| NCT03953209 | WITHDRAWN | Melasma |
Medical University of South Carolina |
2020-03-05 | PHASE1 |
| NCT02230891 | COMPLETED | Hypertension; Diabetes; Cardiovascular Disease |
VA Office of Research and Development |
2014-10-01 | PHASE2 |
| NCT03953950 | UNKNOWN | End Stage Renal Disease; Peritoneal Dialysis |
Chiang Mai University |
2019-10 | PHASE4 |
| NCT03626506 | UNKNOWN | Hypertension |
Peking University Third Hospital |
2019-02-13 | |
| NCT03597035 | TERMINATED | Type2 Diabetes; Hyperkalemia |
University Hospitals Cleveland Medical Center |
2018-07-17 | PHASE4 |
| NCT04424134 | UNKNOWN | COVID 19 |
Lomonosov Moscow State University Medical Research and Educational Center |
2020-05-16 | PHASE3 |
| NCT04393493 | COMPLETED | Cardiorenal Syndrome |
Hospital Civil de Guadalajara |
2017-07-01 | PHASE2 |
| NCT03682497 | TERMINATED | Heart Failure |
AstraZeneca |
2018-11-01 | PHASE1 |
| NCT02907749 | COMPLETED | Cirrhosis; Portal Hypertension |
Changqing Yang |
2018-01-01 | PHASE4 |
| NCT03206658 | UNKNOWN | Acute Kidney Injury |
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran |
2017-08-01 | PHASE3 |
| NCT02948998 | UNKNOWN | Hypertrophic Cardiomyopathy; Fibrosis |
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine |
2018-05-14 | PHASE4 |
| NCT03174288 | COMPLETED | Type 1 Diabetes |
University of Virginia |
2015-08 | |
| NCT03909529 | COMPLETED | Drug Drug Interaction |
CMP Development, LLC |
2019-03-10 | PHASE1 |
| NCT02673463 | UNKNOWN | Atrial Fibrillation |
University of Birmingham |
2015-01 | PHASE4 |
| NCT02689843 | COMPLETED | Polycystic Ovary Syndrome |
Shiraz University of Medical Sciences |
2018-02-01 | EARLY_PHASE1 |
| NCT03071263 | COMPLETED | Hyperkalemia; Resistant Hypertension |
Relypsa, Inc. |
2017-01-23 | PHASE2 |
| NCT02040441 | COMPLETED | Diabetic Nephropathy; Diabetic Retinopathy |
Peter Rossing |
2014-03 | PHASE2; PHASE3 |
| NCT02575963 | COMPLETED | AML |
Actinium Pharmaceuticals |
2012-10 | PHASE1; PHASE2 |
| NCT03329443 | COMPLETED | Acute Kidney Injury; IHD; Contrast-induced Nephropathy |
Alhasan Mujtaba Abdul-Wahid |
2017-09-01 | PHASE2 |
| NCT02483195 | WITHDRAWN | Female Androgenetic Alopecia |
University of Florida |
2016-08 | PHASE4 |
| NCT03981861 | COMPLETED | PCOS |
Children's Mercy Hospital Kansas City |
2016-07-02 | PHASE2; PHASE3 |
| NCT01855334 | WITHDRAWN | End Stage Renal Disease; Hemodialysis |
Brigham and Women's Hospital |
2013-09 | PHASE4 |
| NCT03291145 | COMPLETED | Long Qt Syndrome 1-2; Sudden Cardiac Death |
Herlev and Gentofte Hospital |
2017-06-27 | |
| NCT02236520 | COMPLETED | Hypertension |
Vanderbilt University |
2014-09 | PHASE2 |
| NCT02299726 | WITHDRAWN | Acute Heart Failure |
Indiana University |
2015-05 | PHASE2 |
| NCT02354352 | COMPLETED | Duchenne Muscular Dystrophy |
Ohio State University |
2015-03-20 | PHASE3 |
| NCT02253394 | TERMINATED | Pulmonary Arterial Hypertension |
Brigham and Women's Hospital |
2015-09 | PHASE4 |
| NCT02502981 | UNKNOWN | Renal Insufficiency, Chronic; Cardio-Renal Syndrome |
University Hospital Birmingham |
2014-06 | PHASE4 |
| NCT02883400 | COMPLETED | Transplant, Liver |
Wake Forest University Health Sciences |
2014-12 | PHASE4 |
| NCT02832973 | COMPLETED | Hypertension Resistant to Conventional Therapy |
Sao Jose do Rio Preto Medical School |
2015-09 | PHASE4 |
| NCT01198496 | UNKNOWN | Hypertension; Stroke; Blood Pressure |
Biomedis International Ltd. |
2010-10 | PHASE4 |
| NCT02501213 | TERMINATED | Cancer |
Centre Oscar Lambret |
2016-05-30 | PHASE2 |
| NCT02531412 | UNKNOWN | Critically Ill; Cancer |
Instituto Nacional de Cancerologia de Mexico |
2015-10 | PHASE2; PHASE3 |
| NCT00328809 | WITHDRAWN | End Stage Renal Disease; Congestive Heart Failure |
State University of New York - Upstate Medical University |
2013-06-30 | PHASE4 |
| NCT02285920 | COMPLETED | End-Stage Renal Disease |
University of Pennsylvania |
2014-11 | PHASE2 |
| NCT01973335 | COMPLETED | Heart Failure |
Hasselt University |
2013-11 | PHASE4 |
| NCT02585843 | COMPLETED | Heart Failure |
Columbia University |
2015-11 | PHASE2; PHASE3 |
| NCT01691053 | COMPLETED | End Stage Renal Disease / Hemodialysis |
Wuerzburg University Hospital |
2012-12 | PHASE2 |
| NCT02764619 | UNKNOWN | Atrial Fibrillation |
Svendborg Hospital |
2013-12 | PHASE3 |
| NCT01853553 | COMPLETED | ADPKD |
University of Colorado, Denver |
2013-07 | PHASE3 |
| NCT01721655 | UNKNOWN | Chronic Lung Disease; Bronchopulmonary Dysplasia |
West Virginia University Healthcare |
2012-10 | PHASE2; PHASE3 |
| NCT03314493 | COMPLETED | Coronary Artery Calcification; Vascular Calcification |
Professor Fernando Figueira Integral Medicine Institute |
2014-11-07 | PHASE3 |
| NCT01294319 | COMPLETED | Cortisol Resistance; Negative Feedback; ACTH; Mineralcorticoid; Glucocorticoid |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
2011-01-24 | PHASE2 |
| NCT01069510 | COMPLETED | Congenital Heart Disease; Heart Failure; Endomyocardial Fibrosis |
Oregon Health and Science University |
2010-02 | PHASE2 |
| NCT03547895 | COMPLETED | Decompensated Cirrhosis |
Zagazig University |
2015-06-01 | |
| NCT02235077 | COMPLETED | Heart Failure |
Duke University |
2014-12-30 | PHASE2 |
| NCT02047422 | WITHDRAWN | Congestive Heart Failure |
Yonsei University |
2014-01 | |
| NCT02190318 | UNKNOWN | Chronic Renal Disease |
Second Xiangya Hospital of Central South University |
2013-11 | |
| NCT02429388 | WITHDRAWN | Heart Failure |
The University of Texas Health Science Center at San Antonio |
2014-05 | PHASE4 |
| NCT01801228 | WITHDRAWN | Ascites; Cirrhosis |
Emma Nilsson |
2013-02 | PHASE2 |
| NCT03744767 | COMPLETED | Neovascular Age-related Macular Degeneration |
Dr Irmela MANTEL |
2014-09-19 | PHASE2 |
| NCT01195805 | COMPLETED | Essential Hypertension |
Regional Hospital Holstebro |
2010-08 | |
| NCT02417896 | UNKNOWN | Acute Kidney Injuries; Kidney Injuries, Acute; Kidney Injury, Acute; Acute Renal Injury; Acute Renal Injuries |
Instituto Nacional de Cardiologia Ignacio Chavez |
2013-04 | |
| NCT02369081 | UNKNOWN | Hypertension, Resistant to Conventional Therapy |
University of Cambridge |
2009-05 | PHASE4 |
| NCT01468571 | UNKNOWN | Pulmonary Hypertension |
Baylor College of Medicine |
2011-07 | PHASE4 |
| NCT01817803 | WITHDRAWN | Congestive Heart Failure |
Yonsei University |
2013-03 | |
| NCT02194465 | COMPLETED | Primary Hypertension |
Eli Lilly and Company |
2014-08 | PHASE2 |
| NCT01843309 | TERMINATED | Patients With Fungic Infections |
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran |
2013-05 | PHASE4 |
| NCT01586442 | COMPLETED | Heart Failure; Type 2 Diabetes; Glucose Intolerance |
Montreal Heart Institute |
2012-03 | PHASE3 |
| NCT02046668 | COMPLETED | Osteoarthritis, Knee |
University of Dundee |
2013-11 | PHASE4 |
| NCT00604006 | COMPLETED | Heart Failure |
Monash University |
2008-09 | PHASE3 |
| NCT01059136 | COMPLETED | Myocardial Infarction |
Assistance Publique - Hôpitaux de Paris |
2010-02 | PHASE3 |
| NCT01867294 | COMPLETED | Advanced Malignant Neoplasm; Dermatologic Complication |
Academic and Community Cancer Research United |
2012-08-31 | PHASE2 |
| NCT01643434 | UNKNOWN | Hypertension |
Instituto do Coracao |
2012-08 | PHASE4 |
| NCT01821703 | COMPLETED | Healthy Volunteers |
Eli Lilly and Company |
2013-05 | PHASE1 |
| NCT01406015 | COMPLETED | Obesity; Insulin Resistance |
Brigham and Women's Hospital |
2009-02 | |
| NCT00865124 | COMPLETED | Type 2 Diabetes Mellitus; Vascular Disease |
Brigham and Women's Hospital |
2008-09 | |
| NCT01510795 | UNKNOWN | Kidney Failure, Chronic |
Clinical Hospital Merkur |
2012-01 | PHASE4 |
| NCT00094302 | COMPLETED | Cardiovascular Diseases; Heart Diseases; Heart Failure, Congestive |
Carelon Research |
2006-08 | PHASE3 |
| NCT01371747 | COMPLETED | Chronic Kidney Disease; Hypertension; Hyperkalemia |
Relypsa, Inc. |
2011-06 | PHASE2 |
| NCT00353652 | COMPLETED | Hypertension |
University of Texas Southwestern Medical Center |
2005-01 | PHASE4 |
| NCT01552044 | COMPLETED | Central Serous Chorioretinitis |
Institut National de la Santé Et de la Recherche Médicale, France |
2012-01 | PHASE1; PHASE2 |
| NCT01128101 | UNKNOWN | Renal Failure |
UPECLIN HC FM Botucatu Unesp |
2011-03 | PHASE4 |
| NCT02129621 | COMPLETED | Cardiovascular Diseases |
Central Hospital, Nancy, France |
2010-05 | |
| NCT00524615 | UNKNOWN | Hypertension |
Jan Vaclavík |
2007-09 | PHASE4 |
| NCT02053974 | COMPLETED | Anthracycline Induced Cardiotoxicity |
TC Erciyes University |
2011-09 | PHASE4 |
| NCT02426099 | COMPLETED | Hypertension, Resistant to Conventional Therapy; Diabetes Mellitus |
Sobngwi Eugene |
2011-10 | PHASE4 |
| NCT01598740 | COMPLETED | Heart Failure |
Sorbent Therapeutics |
2012-06 | PHASE1 |
| NCT01103245 | COMPLETED | Metabolic Diseases; Diabetes Mellitus; Endocrine System Diseases; Glucose Metabolism Disorders |
Vanderbilt University Medical Center |
2010-03 | PHASE1 |
| NCT01488877 | TERMINATED | Type 2 Diabetic Nephropathy |
Pfizer |
2012-01 | PHASE1 |
| NCT00574119 | COMPLETED | Heart Failure; Nonischemic Dilated Cardiomyopathy |
Vanderbilt University |
2007-12 | PHASE4 |
| NCT01345656 | COMPLETED | Heart Failure |
Bayer |
2011-05-09 | PHASE2 |
| NCT01407471 | COMPLETED | Cutaneous Atrophy Due to Corticosteroids |
Assistance Publique - Hôpitaux de Paris |
2011-09 | PHASE2 |
| NCT01897727 | COMPLETED | Obstructive Sleep Apnea; Resistant Hypertension; Hyperaldosteronism |
University of Alabama at Birmingham |
2009-01 | |
| NCT01667614 | COMPLETED | Type 2 Diabetes Mellitus; Diabetic Nephropathy; Essential Hypertension |
Tehran University of Medical Sciences |
2010-05 | PHASE2 |
| NCT01062763 | COMPLETED | Arterial Hypertension; Hypertension, Resistant to Conventional Therapy; Diabetes Mellitus |
Ib Abildgaard Jacobsen |
2010-03 | PHASE3 |
| NCT01388088 | COMPLETED | Hypertension |
Erling Bjerregaard Pedersen |
2010-09 | PHASE4 |
| NCT00865449 | COMPLETED | End Stage Renal Disease |
Instituto Nacional de Cardiologia Ignacio Chavez |
2008-07 | PHASE3 |
| NCT00879060 | COMPLETED | Myocardial Fibrosis; Hypertrophic Cardiomyopathy |
Tufts Medical Center |
2007-11 | PHASE4 |
| NCT00226109 | SUSPENDED | Cardiomyopathy, Alcoholic; Alcoholism |
University of Aarhus |
2004-04 | PHASE4 |
| NCT01314898 | COMPLETED | Healthy Volunteers |
Pfizer |
2011-03 | PHASE1 |
| NCT01526616 | COMPLETED | Polycystic Ovary Syndrome |
University Magna Graecia |
2010-05 | |
| NCT00689598 | UNKNOWN | Atrial Fibrillation |
Taichung Veterans General Hospital |
2008-03 | |
| NCT01147523 | COMPLETED | Fatty Liver; Steatohepatitis |
Aristotle University Of Thessaloniki |
2010-01 | PHASE2 |
| NCT00709137 | WITHDRAWN | Hypertension |
VA Salt Lake City Health Care System |
2008-10 | |
| NCT01130597 | COMPLETED | Heart Failure |
Relypsa, Inc. |
2010-05 | PHASE2 |
| NCT00811486 | WITHDRAWN | Right Heart Failure; Pulmonary Hypertension |
University of Colorado, Denver |
2009-01 | |
| NCT00206232 | COMPLETED | Heart Failure |
Baylor College of Medicine |
2004-07 | PHASE4 |
| NCT00141778 | COMPLETED | Atrial Fibrillation |
Vanderbilt University |
2005-04 | PHASE2; PHASE3 |
| NCT00857909 | COMPLETED | High Blood Pressure |
Regional Hospital Holstebro |
2009-01 | PHASE1 |
| NCT00637078 | COMPLETED | Hypertension; Hypercholesterolemia |
University of Western Ontario, Canada |
2008-02 | PHASE4 |
| NCT00523757 | COMPLETED | Heart Failure |
Justin Ezekowitz |
2007-08 | PHASE3 |
| NCT01083290 | COMPLETED | Healthy |
Orion Corporation, Orion Pharma |
2010-04 | PHASE1 |
| NCT00870402 | UNKNOWN | Diabetic Nephropathy |
Universidad de los Andes, Chile |
2009-03 | PHASE4 |
| NCT00865501 | COMPLETED | Primary Hypertension |
University of Erlangen-Nürnberg Medical School |
2008-03 | PHASE3 |
| NCT00773084 | WITHDRAWN | Diastolic Heart Failure |
Texas Tech University Health Sciences Center |
2008-09 | |
| NCT00292162 | COMPLETED | Chronic Heart Failure; Atrial Fibrillation |
NHS Greater Glasgow and Clyde |
2007-01 | |
| NCT00123955 | COMPLETED | Diastolic Heart Failure; Heart Failure, Congestive |
Wake Forest University |
2005-04 | PHASE3 |
| NCT00175617 | COMPLETED | Female Pattern Hair Loss |
University of British Columbia |
2005-09 | PHASE2 |
| NCT00842140 | COMPLETED | Polycystic Ovary Syndrome |
University of Sao Paulo |
2006-02 | |
| NCT00391846 | COMPLETED | Heart Failure; Ventricular Dysfunction, Left |
AstraZeneca |
2006-10 | PHASE4 |
| NCT01687699 | COMPLETED | End-stage Renal Failure |
Dialysis Outcomes Heart Failure Aldactone Study Group |
2008-04 | PHASE4 |
| NCT00548912 | WITHDRAWN | Kidney Failure, Chronic |
Dawnmarie DeFazio |
2007-10 | PHASE4 |
| NCT00741663 | COMPLETED | Cirrhosis; Ascites |
University of Padova |
2005-04 | PHASE4 |
| NCT00332904 | UNKNOWN | Liver Cirrhosis; Portal Hypertension |
Hvidovre University Hospital |
2006-08 | PHASE4 |
| NCT00295347 | COMPLETED | Major Depression |
Universitätsklinikum Hamburg-Eppendorf |
2005-12 | |
| NCT00211081 | COMPLETED | Congenital Disorders |
Emory University |
2004-11 | |
| NCT04495712 | COMPLETED | Ventricular Arrhythmias |
VA Office of Research and Development |
2004-07-28 | PHASE4 |
| NCT00291720 | COMPLETED | Chronic Kidney Disease; Cardiovascular Disease |
University Hospital Birmingham |
2005-04 | PHASE2 |
| NCT01089309 | COMPLETED | Arterial Stiffness; Arterial Elasticity |
Wolfson Medical Center |
2004-05 | PHASE4 |
| NCT00860340 | COMPLETED | Congestive Heart Failure |
University of Toledo Health Science Campus |
2003-02 | |
| NCT00498537 | COMPLETED | Diabetic Nephropathy |
US Department of Veterans Affairs |
2003-01 | |
| NCT00335413 | COMPLETED | Hypertension |
Steno Diabetes Center Copenhagen |
2006-06 | PHASE4 |
| NCT00527059 | UNKNOWN | Heart Failure; Renal Insufficiency |
University of Roma La Sapienza |
2007-10 | PHASE4 |
| NCT00429897 | UNKNOWN | Low-Renin Hypertension |
University of Cambridge |
2006-08 | |
| NCT00188045 | TERMINATED | Alcoholic Cirrhosis |
University Hospital, Angers |
1995-04 | PHASE4 |
| NCT00663195 | COMPLETED | Chronic Stable Heart Failure |
Tottori University Hospital |
2004-01 | PHASE4 |
| NCT00306696 | COMPLETED | Diabetes Mellitus |
GlaxoSmithKline |
2002-10 | PHASE4 |
| NCT00317954 | COMPLETED | Diabetic Nephropathy |
Steno Diabetes Center Copenhagen |
2003-09 | PHASE4 |
| NCT00224809 | COMPLETED | Cardiovascular Diseases; Heart Diseases; Coronary Disease |
Baylor Research Institute |
2002-09 | |
| NCT00106561 | COMPLETED | Kidney Disease; Diabetic Nephropathy; Glomerulonephritis; Proteinuria |
Melbourne Health |
2002-01 | PHASE2; PHASE3 |
| NCT00430794 | TERMINATED | Hypertension |
Sheffield Teaching Hospitals NHS Foundation Trust |
2007-03 | PHASE2 |
| NCT00001202 | COMPLETED | Precocious Puberty |
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
1985-01 | PHASE2 |
| NCT00125437 | TERMINATED | Heart Failure, Congestive |
Hebei Medical University |
2005-09 | |
| NCT00664222 | COMPLETED | Chronic Stable Heart Failure |
Tottori University Hospital |
2004-01 | PHASE4 |
| NCT00240656 | COMPLETED | Hypertension, Pulmonary |
Hebei Medical University |
2005-10 | PHASE1 |
| NCT00277693 | UNKNOWN | Hemodialysis |
Universidad de los Andes, Chile |
PHASE4 | |
| NCT01021943 | SUSPENDED | Kidney Transplant |
Instituto Nacional de Cardiologia Ignacio Chavez |
2009-11 | PHASE2 |
| NCT00004311 | COMPLETED | Acanthosis Nigricans; Polycystic Ovary Syndrome |
National Center for Research Resources (NCRR) |
1989-07 | PHASE2 |
| NCT00276289 | COMPLETED | Idiopathic Hypercalciuria; Hypokalemia Caused by Thiazide Diuretics |
Indiana University |
2006-01 | |
| NCT00528385 | COMPLETED | Chronic Kidney Disease; Proteinuria |
Medical University of Gdansk |
2005-03 | |
| NCT00381134 | COMPLETED | Diabetes; Kidney Disease; Hypertension |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
2003-07 | PHASE2 |
(data from https://clinicaltrials.gov, updated on 2025-06-13)
Check the
Spironolactone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
Note: Technical data last updated: Sep 1, 2026.