CAS No. 1262888-28-7
Batch:
Purity:99.93
Chemical Structure
Check the
Spautin-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-fluoro-N-[(4-fluorophenyl)methyl]quinazolin-4-amine | |
|---|---|---|
| CAS Number | 1262888-28-7 | |
| Molecular Formula |
C15H11F2N3 |
|
| Molecular Weight (MW) | 271.26 | |
| SMILES | C1=CC(=CC=C1CNC2=NC=NC3=C2C=C(C=C3)F)F | |
| InChIKey | AWIVHRPYFSSVOG-UHFFFAOYSA-N |
Spautin-1 is a potent autophagy inhibitor that targets the deubiquitinating enzymes USP10 and USP13. Inhibition of USP10 and USP13 by Spautin-1 accelerates the ubiquitin-proteasomal degradation of class III PI3K complexes, including Beclin1 and Vps34. This suppression of PI3K activity leads to the inhibition of autophagy and markedly enhances apoptotic cell death. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(199.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
| DMSO |
54 mg/mL
(199.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 54 mg/mL |
| Water | Insoluble |
| DMSO |
40 mg/mL
(147.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.