Cell-free Assays (IC50/Ki) for SP600125
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| Mps1 kinase domain | 692 nM | Universal Fluorometric Kinase Assay Kit | Download PDF |
| JNK1 | 40 nM | Cell free assay | Download PDF |
| JNK2 | 40 nM | Cell free assay | Download PDF |
| JNK3 | 90 nM | Cell free assay | Download PDF |
Cell-based Assay (IC50) for SP600125
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| U87 | 19.6 ± 2.5 µM (24h), 7.3 ± 0.9 µM (48h) | MTT assay | Download PDF |
| U118 | 58 ± 6.8 µM (24h), ~40 µM (48h) | MTT assay | Download PDF |
| EPNT-5 | 104.7 ± 29.2 µM (24h), ~40 µM (48h) | MTT assay | Download PDF |
| GL261 | 65.2 ± 18.5 µM (24h), ~40 µM (48h) | MTT assay | Download PDF |
| hFF3 | >100 µM (24h), 87.1 ± 22.7 µM (48h) | MTT assay | Download PDF |
| Jurkat T cells | 5-10 μM | Inhibition of c-Jun phosphorylation | Download PDF |
| LLC cells | 19.26 μM | MTT assay | PMC6859088 |
Check the
SP600125
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
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- SP600125 Mechanism of Action: JNK Inhibition in Cancer Cell Research
- SP600125 Working Concentration | Cell Culture | Treatment
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