CAS No. 129-56-6
Batch:
Purity:99.94
Chemical Structure
Check the
SP600125
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one | |
|---|---|---|
| CAS Number | 129-56-6 | |
| Molecular Formula |
C14H8N2O |
|
| Molecular Weight (MW) | 220.23 | |
| SMILES | C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O | |
| InChIKey | ACPOUJIDANTYHO-UHFFFAOYSA-N |
SP600125 is a reversible, ATP-competitive inhibitor targeting JNK1, JNK2, and JNK3 with over 300-fold selectivity over ERK1 and p38. By suppressing JNK signaling, SP600125 inhibits c-Jun phosphorylation and reduces the expression of inflammatory cytokines such as IL-2, IFN-gamma, and TNF-alpha, thereby blocking CD4 T cell differentiation and promoting apoptosis. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(272.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
44 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
44 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
44 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
44 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- SP600125 Mechanism of Action: JNK Inhibition in Cancer Cell Research
- SP600125 Working Concentration | Cell Culture | Treatment
- SP600125 Solubility in DMSO
- SP600125 Stock Solution
- SP600125 Storage
- SP600125 Stability
- SP600125 Combination Database
- SP600125 Molecular Weight
- SP600125 SMILES
- SP600125 Chemical Structure (2D and 3D)
- SP600125 IC50 for Cell-based and Cell-free Assays
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- SP600125 Sigma (S5567)? Try a better option.
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- SP600125 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.