CAS No. 425637-18-9

Batch: Purity:99.97
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Sotrastaurin (AEB071) Chemical Structure
Chemical Structure
Check the Sotrastaurin (AEB071) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
CAS Number 425637-18-9
Molecular Formula

C25H22N6O2
Molecular Weight (MW) 438.48
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
InChIKey OAVGBZOFDPFGPJ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Sotrastaurin (AEB071) is a potent pan-protein kinase C (PKC) inhibitor, demonstrating targeted selectivity for PKCθ. By inhibiting classical and novel PKC isoforms, it downregulates NF-kB signaling, suppresses early T-cell activation markers such as interleukin-2 secretion, and reduces T-cell proliferation. Additionally, sotrastaurin impairs growth and induces G1 cell-cycle arrest in CD79-mutant diffuse large B-cell lymphoma cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 87 mg/mL (198.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 40 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.