CAS No. 760981-83-7
Batch:
Purity:99.82
Chemical Structure
Check the
Solithromycin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 760981-83-7 | |
|---|---|---|
| Molecular Formula |
C43H65FN6O10 |
|
| Molecular Weight (MW) | 845.01 | |
| SMILES | CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)(C)F)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=N4)C5=CC(=CC=C5)N)C |
Solithromycin (CEM-101) is a fluoroketolide antibiotic and potent inhibitor of bacterial protein synthesis. It targets the bacterial 50S ribosomal subunit by binding to domain V of 23S rRNA, effectively disrupting peptide bond formation and ribosome translocation. This inhibition halts bacterial translation, downstream protein accumulation, and pathogen growth across various Gram-positive and Gram-negative respiratory tract bacteria. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(118.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(118.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 13 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.