CAS No. 54-21-7
| IUPAC Name | sodium 2-hydroxybenzoate | |
|---|---|---|
| CAS Number | 54-21-7 | |
| Molecular Formula |
C7H6O3.Na |
|
| Molecular Weight (MW) | 161.11 | |
| SMILES | C1=CC=C(C(=C1)C(=O)[O-])O.[Na+] | |
| InChIKey | ABBQHOQBGMUPJH-UHFFFAOYSA-M |
Sodium salicylate is an orally active nonsteroidal anti-inflammatory agent and an inhibitor of the NF-κB signaling pathway. It suppresses NF-κB activation by preventing the phosphorylation and degradation of IκB-α, predominantly through the inhibition of IκB kinase β (IKKβ). Downstream, inhibition of NF-κB leads to reduced expression of pro-inflammatory cytokines and enzymes, resulting in suppressed inflammatory responses and decreased cellular proliferation in various cell models. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
32 mg/mL
(198.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 32 mg/mL |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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