CAS No. 10040-45-6

Batch: Purity:99.69
Sodium Picosulfate Chemical Structure
Chemical Structure
Check the Sodium Picosulfate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 10040-45-6
Molecular Formula

C18H15NO8S2.2Na

Molecular Weight (MW) 481.41
SMILES C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+]

Ordering Information

Biological Activity

Sodium picosulfate is a contact stimulant laxative that undergoes colonic bacterial cleavage to generate its active metabolite, bis(p-hydroxyphenyl)-pyridyl-2-methane. This active metabolite acts directly on the intestinal mucosa to inhibit the absorption of water and electrolytes while stimulating their secretion into the lumen. Consequently, it accelerates peristalsis, increases intraluminal fluid accumulation, and promotes intestinal motility.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 96 mg/mL (199.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 96 mg/mL
Ethanol 3 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.