🛡️ Hazard Overview
- GHS Class: None
- Signal Word: Not applicable
- Hazard Statements: None
🧤 PPE Guidelines
- Gloves: Chemical‑resistant gloves suggested
- Eye Protection: Safety goggles suggested
- Respirator: Dust respirator if dust occurs
❄️ Storage
- Storage Temp: -20°C (-4°F) Keep dry
🚑 Emergency First Aid
- For inhalation, skin, eye or ingestion exposure, please refer to full SDS Section 4.
Product identifier
- Product Name: Sodium Bicarbonate
- Catalog Number: E2895
- CAS Number: 144-55-8
- IUPAC Name: Carbonic acid sodium salt (1: 1)
Relevant identified uses and uses advised against
- Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
- Uses advised against: Not for pharmaceutical, household, or other unapproved uses.
Details of the supplier
- Company: Selleck Chemicals
- TollFree: +1 877 796-6397
- Tel: +1 832 582-8158
- Fax: +1 832 582-8590
Emergency telephone number
- Emergency phone #: +1 832 582-8158
2.1 GHS classification in accordance with 29 CFR 1910 (OSHA HCS):
Not classified as a hazardous substance according to GHS.
2.2 GHS Label elements, including precautionary statements
Hazard Pictogram(s):
None.
Signal Word:
Not applicable
Hazard statement(s):
None.
Precautionary statement(s):
None.
2.3 Other hazards
None.
3.1 Substances
Product name: Sodium Bicarbonate
CAS Number: 144-55-8
PubChem CID: 516892
3.2 Mixtures
Not applicable (pure substance).
4.1 Description of first aid measures
Inhalation: Fresh air.
Skin contact: SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
Eye contact: Rinse with plenty of water (remove contact lenses if easily possible).
Ingestion: Give one or two glasses of water to drink.
4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).
4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.
5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.
5.2 Specific hazards arising from the substance or mixture
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
In case of fire in the surroundings, use appropriate extinguishing media.
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.
In case of fire in the surroundings: use appropriate extinguishing media.
5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.
6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.
6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.
6.3 Methods and materials for containment and cleaning up
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures Avoid dust formation. Avoid breathing vapors, mist or gas. Environmental precautions: No special environmental precautions required. Methods and materials for containment and cleaning up: Sweep up and shovel. Keep in suitable, closed containers for disposal.
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging: Dispose of as unused product.
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures Avoid dust formation. Avoid breathing vapors, mist or gas. Environmental precautions: No special environmental precautions required.
Precautions for safe handling: Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.
Appropriate engineering controls: General industrial hygiene practice.
Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.
7.1 Precautions for safe handling
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. If possible, it would be prudent to store this compound under inert atmosphere. (NTP, 1992)
Separated from incompatible materials. See Chemical Dangers.
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Sodium bicarbonate tablets and effervescent tablets should be stored in tightly closed containers at a temperature less than 40 °C, preferably between 15-30 °C. Sodium bicarbonate injection should be stored at a temperature less than 40 °C, preferably between 15-30 °C; freezing should be avoided.
/Stored/ separated from acids.
7.2 Conditions for safe storage, including any incompatibilities
Separated from incompatible materials. See Chemical Dangers.
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Sodium bicarbonate tablets and effervescent tablets should be stored in tightly closed containers at a temperature less than 40 °C, preferably between 15-30 °C. Sodium bicarbonate injection should be stored at a temperature less than 40 °C, preferably between 15-30 °C; freezing should be avoided.
/Stored/ separated from acids.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]
8.1 Exposure controls
8.1.1 Occupational exposure limits (OEL)
OSHA PEL: Not established.
ACGIH TLV: Not established.
NIOSH REL: Not established.
No occupational exposure limit values are established for this substance.
Use the lowest feasible exposure level (ALARA principle).
8.1.2 Appropriate engineering controls
Use in a well-ventilated area. Chemical fume hood recommended for powder handling.
8.2 Individual protection measures
8.2.1 Eye/face protection
Wear safety glasses with side shields.
8.2.2 Skin protection
Wear protective gloves. Recommended material: Nitrile rubber.
Wear suitable protective clothing (lab coat).
8.2.3 Respiratory protection
Respiratory protection usually not required under normal use with adequate ventilation.
Use N95 respirator for large-scale powder handling.
8.2.4 Thermal hazards
Not applicable.
9.1 Information on basic physical and chemical properties
a) Appearance: Sodium bicarbonate appears as odorless white crystalline powder or lumps. Slightly alkaline (bitter) taste. pH (of freshly prepared 0.1 molar aqueous solution): 8.3 at 77 °F. pH (of saturated solution): 8-9. Non-toxic.
b) Odor: Odorless
c) Odor threshold: No data available
d) pH: Between 8,0 and 8,6 (1 % solution)
e) Melting point/freezing point: Decomposes at 228 °F (NTP, 1992)
f) Initial boiling point and boiling range: No data available
g) Flash point: No data available
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: No data available
l) Vapor density: No data available
m) Relative density: 2.159 (NTP, 1992) - Denser than water; will sink
n) Water solubility: 1 in 10 % at 77 °F (NTP, 1992)
o) Partition coefficient: n-octanol/water: Log P: No data available
p) Auto-ignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available
9.2 Other information
10.1 Reactivity
No specific reactivity hazards identified under normal handling conditions.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No hazardous reactions under normal conditions.
10.4 Conditions to avoid
Avoid heat, sparks, open flames, direct sunlight, and moisture.
10.5 Incompatible materials
Incompatible materials: Strong acids, strong oxidizing agents.
A mixture /of sodium hydrogen carbonate, carbon and water/ was being stirred and steam heated when power failure interrupted stirring, and heating was turned off for a hour before power was restored. When stirring was restarted, the hot contents of the pan erupted immediately. Carbon dioxide is evolved from warm aqueous solutions of the base, and absence of stirring and presence of the carbon adsorbent would lead to non-equilibrium retention of the gas, which would be released instantaneously on stirring.
Several cases of spontaneous ignition after exposure to air of fine coke particles removed from filter strainers on a petroleum refinery furfural extraction unit have been noted. This has been associated with the use of sodium hydrogen carbonate (bicarbonate) injected into the plant for pH control, which produced a pH of 10.5 locally. This would tend to resinify the aldehyde, but there is also the possibility of a Cannizzaro reaction causing conversion of the aldehyde to furfuryl alcohol and furoic acid. The latter, together with other acidic products of autoxidation of the aldehyde, would tend to resinify the furfuryl alcohol. Pyrolysis gas-liquid chromatography (GLC) showed the presence of a significant proportion of furfuryl alcohol-derived resins in the coke. The latter is now discarded into drums of water, immediately after discharge from the strainers, to prevent further incidents. /2-Furaldehyde (Furfural): sodium hydrogen carbonate/
A self-propagating reaction can occur when ... sodium bicarbonate- ... based dry chemical extinguishing agent is mixed with monoammonium phosphate dry chemical extinguishing agent. Moisture will accelerate reaction. Products are water, ammonia, carbon dioxide and various solid substances. In a fire extinguisher the pressure developed will blow out the valve.
Sodium-potassium alloy undergoes a violent reaction with certain extinguishing agents: water, sodium bicarbonate, carbon tetrachloride. /Sodium-potassium alloy: water/
10.6 Hazardous decomposition products
No data available.
See also Section 5 (Fire-fighting measures) for combustion products.
11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
No data available.
Respiratory or skin sensitization:
No data available.
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
No data available.
Specific target organ toxicity (single exposure):
No data available.
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.
11.2 Additional information
Exposure routes:
The substance can be absorbed into the body by ingestion.
Signs and symptoms of exposure:
Cough.
Redness.
No acute symptoms expected.
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.
12.1 Toxicity
LC50; Species: Gambusia affinis (Western mosquitofish) adult; Conditions: freshwater, static, 20-22 °C, pH 7.3-9.2; Concentration: 7700000 ug/L for 24 hr /formulation/
LC50; Species: Gambusia affinis (Western mosquitofish) adult; Conditions: freshwater, static, 20-22 °C, pH 7.3-9.2; Concentration: 7550000 ug/L for 48-96 hr /formulation/
EC50; Species: Skeletonema costatum (Diatom) 1.25X10+7 cells/mL; Conditions: saltwater, static, 20 °C, pH 5.73-8.45; Concentration: 52000 ug/L for 4 hr; Effect: physiology, decreased photosynthesis
LC50; Species: Lepomis macrochirus (Bluegill); Conditions: freshwater, static, 18 °C, dissolved oxygen 5-9 mg/L; Concentration: 8600000 ug/L for 96 hr
For more Ecotoxicity Values (Complete) data for Sodium bicarbonate (17 total), please visit the HSDB record page.
/AQUATIC SPECIES/ Some tributaries in the Powder River Structural Basin, USA /southeast Montana and northeast Wyoming/, were historically ephemeral, but now contain water year round as a result of discharge of coalbed natural gas (CBNG)-produced waters. This presented the opportunity to study field sites with 100% effluent water with elevated concentrations of sodium bicarbonate. In situ experiments, static renewal experiments performed simultaneously with in situ experiments, and static renewal experiments performed with site water in the laboratory demonstrated that CBNG-produced water reduces survival of fathead minnow (Pimephales promelas) and pallid sturgeon (Scaphirhynchus albus). Ag
12.2 Persistence and degradability
No data available.
12.3 Bioaccumulative potential
No data available.
12.4 Mobility in soil
No data available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.
12.6 Other adverse effects
No other adverse ecological effects identified.
13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.
14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).
14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).
14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).
14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).
14.5 Environmental hazards
Marine pollutant: No (not classified as environmentally hazardous per GHS).
14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered (REACH Active)
SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
No SARA Hazards.
Massachusetts Right To Know Components:
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components:
No components are subject to the Pennsylvania Right to Know Act.
New Jersey Right To Know Components:
No components are subject to the New Jersey Right to Know Act.
California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.
Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: Carbonic acid, monosodium salt
- EFSA Legal Basis: Regulation (EC) No 1107/2009 (amended)
- Status Regulation (EC): 2007/442, 2007/442, Reg. (EU) 2015/2069, Reg. (EU) 2015/2069, Reg. (EU) No 540/2011, Reg. (EU) No 540/2011
- Status Regulation (EC): Reg. (EU) 2020/1263
- FIFRA Requirements: Unless specifically excluded, residues resulting from the use of the following substances as either an inert or an active ingredient in a pesticide chemical formulation, including antimicrobial pesticide chemicals, are exempted from the requirement of a tolerance under FFDCA section 408, if such use
15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.
Revision Date: 2026/09/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.